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Note 2 - Summary of Significant Accounting Policies (Details Textual)			9 Months Ended	12 Months Ended
	Jul. 16, 2024 USD ($)	Jul. 15, 2024 USD ($)	Sep. 30, 2024	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	May 07, 2024 $ / shares	Jan. 03, 2024 $ / shares
Government Assistance, Income, Increase (Decrease)				$ 0	$ 0	$ 900,000
Class of Warrant or Right, Fair Value of Common Stock Warrants per Warrant (in dollars per share) | $ / shares								$ 6.71
Class of Warrant or Right, Redemption Price per Share (in dollars per share) | $ / shares							$ 0.001
Number of Operating Segments				1
Net Cash Provided by (Used in) Operating Activities				$ (116,929,000)	(82,025,000)	$ (77,514,000)
Proceeds from Insurance Settlement, Operating Activities				9,900,000	$ 100,000
Insurance Settlements, Maximum Recovery Limit				$ 10,000,000
Government Assistance, Income, Increase (Decrease), Statement of Income or Comprehensive Income [Extensible Enumeration]				Research and development
Former Senior Vice President [Member]
Consulting Agreement, Term	1
Consulting Service, Price Per Hour	$ 500
Related Party Transaction, Amounts of Transaction				$ 43,000
Former President and Chief Executive Officer [Member]
Severance Costs		$ 1,230,000
Former Senior Vice President [Member]
Severance Costs	$ 500,000
Former Senior Officer [Member]
Severance Costs				$ 1,200,000
Number of Former Employees			2
Building [Member]
Property, Plant and Equipment, Useful Life (Year)				39 years
Building Improvements [Member]
Property, Plant and Equipment, Useful Life (Year)				10 years
Share-Based Payment Arrangement, Option [Member] | Minimum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period (Year)				1 year
Share-Based Payment Arrangement, Option [Member] | Maximum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period (Year)				4 years

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