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Note 9 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 21.00% 21.00% 21.00%  
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount $ 19,400 $ 23,300    
Unrecognized Tax Benefits 9,242 $ 8,413 $ 6,496 $ 5,001
Income Tax Expense (Benefit) 0      
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued $ 0      
Open Tax Year 2020 2021 2022 2023 2024      
Domestic Tax Jurisdiction [Member]        
Operating Loss Carryforwards $ 205,500      
Domestic Tax Jurisdiction [Member] | Research Tax Credit Carryforward [Member]        
Tax Credit Carryforward, Amount 23,000      
Domestic Tax Jurisdiction [Member] | Carryforward Subject to Expiration [Member]        
Operating Loss Carryforwards 74,100      
Domestic Tax Jurisdiction [Member] | Indefinite Life Carryforwards [Member]        
Operating Loss Carryforwards $ 131,400