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Note 7 - Stockholders' Equity and Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2025

Notes Tables

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

						Weighted Average				Weighted Average
		Number of				Weighted Average				Remaining Contractual				Aggregate Intrinsic Value
		Options				Exercise Price				Term in Years
Outstanding as of December 31, 2024			4,463,028			$	20.15				7.61			$	288,000
Options granted			1,655,000				1.68
Options exercised			(225,209	)			1.51
Options forfeited/canceled			(1,735,725	)			17.27
Outstanding as of December 31, 2025			4,157,094				15.01				8.19			$	696,000
Vested and expected to vest at December 31, 2025			4,157,094				15.01				8.19			$	696,000
Exercisable at December 31, 2025			1,557,052			$	20.18				6.82			$	45,000

Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block]

								Options outstanding												Options exercisable
												Weighted
												average				Weighted								Weighted
								Number of				remaining				average				Number of				average
Range of exercise prices								outstanding				contractual				exercise				vested				exercise
From				To				options				life (in years)				price				options				price
$	0.95			$	0.95				34,000				2.7			$	0.95				34,000			$	0.95
$	1.44			$	1.44				1,067,000				9.3			$	1.44				—			$	—
$	1.59			$	5.46				844,520				7.0			$	2.62				393,212			$	3.14
$	8.12			$	26.91				1,360,782				8.1			$	23.50				824,903			$	22.70
$	27.42			$	77.00				850,792				8.3			$	31.30				304,937			$	37.48
									4,157,094				8.2			$	15.01				1,557,052			$	20.18

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		2025				2024				2023
Volatility			149% to 162%				151% to 170%				152% to 155%
Risk-free interest rates			3.78% to 4.21%				3.53% to 4.47%				3.82% to 4.37%
Expected life of option (in years)			7				7				7
Dividend yield		zero				zero				zero
Forfeiture rate		zero				4.37		%		zero
Weighted average fair value of stock options granted		$	1.63			$	25.85			$	18.21

Share-Based Payment Arrangement, Activity [Table Text Block]

		Number of Performance Awards
Outstanding as of December 31, 2024			7,142
Granted			—
Vested			—
Forfeited/canceled			—
Outstanding as of December 31, 2025			7,142

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Years ended December 31,
		2025				2024				2023
Research and development		$	7,159			$	6,492			$	2,050
General and administrative			12,423				9,799				2,536
Total stock-based compensation expense		$	19,582			$	16,291			$	4,586

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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