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Note 9 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2025

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

		Year ended December 31,
		2025								2024				2023
U.S. federal statutory tax rate		$	(19,104	)			21	%			21	%			21	%
Nontaxable or nondeductible items
Stock compensation			3,580				(4.0	)			(5.7	)			0.2
Section 162(m) limitation			—				—				(0.2	)			—
Change in fair value of warrant liabilities			—				—				93.3				—
SEC settlement payment			—				—				(34.5	)			—
Change in valuation allowance			15,207				(16.7	)			(79.4	)			(24.0	)
Tax Credits
Research and development credits			(1,021	)			1.1				15.4				5.1
Tax attribute expiration			922				(1.0	)			(4.1	)			—
Uncertain tax positions			409				(0.4	)			(6.1	)			(2.0	)
State tax, net of federal benefit			—				—				—				—
Other			7				—				0.3				(0.3	)
Effective income tax rate		$	—				—	%			—	%			—	%

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		December 31,
		2025				2024
Deferred tax assets:
Net operating loss carryforwards		$	78,632			$	43,148
Legal reserves			6,563			$	—
Share-based compensation			5,319				4,814
Research and development credit carryforwards			13,480				13,789
Capitalized research and development expenses			6,919				33,598
Other			985				1,340
Total deferred tax assets			111,898				96,689
Valuation allowance			(111,896	)			(96,689	)
Net deferred tax assets			2				—
Deferred tax liabilities:
Intangibles			(2	)			—
Total deferred tax liabilities			(2	)			—
Net deferred tax asset (liability)		$	—			$	—

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

		Year ended December 31,
		2025				2024				2023
Beginning balance		$	9,242			$	8,413			$	6,496
Expired research and development tax credits			(614	)			(665	)			(50	)
Additions based on tax positions related to the current year			392				1,494				1,967
Ending balance		$	9,020			$	9,242			$	8,413

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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