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Note 7 - Stockholders' Equity and Stock-based Compensation - Stock Option Activity (Details) - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Outstanding, options (in shares) 4,463,028  
Outstanding, options, weighted average exercise price (in dollars per share) $ 20.15  
Outstanding as of December 31, 2022, weighted average contractual term (Year) 8 years 2 months 8 days 7 years 7 months 9 days
Outstanding as of December 31, 2022, aggregate intrinsic value $ 696,000 $ 288,000
Options granted (in shares) 1,655,000  
Options granted, weighted average exercise price (in dollars per share) $ 1.68  
Options exercised (in shares) (225,209)  
Options exercised, weighted average exercise price (in dollars per share) $ 1.51  
Options forfeited/canceled (in shares) (1,735,725)  
Options forfeited/canceled, weighted average exercise price (in dollars per share) $ 17.27  
Outstanding, options (in shares) 4,157,094 4,463,028
Outstanding, options, weighted average exercise price (in dollars per share) $ 15.01 $ 20.15
Vested and expected to vest at December 31, 2025 (in shares) 4,157,094  
Vested and expected to vest at December 31, 2022, weighted average exercise price (in dollars per share) $ 15.01  
Vested and expected to vest at December 31, 2022, weighted average contractual term (Year) 8 years 2 months 8 days  
Vested and expected to vest at December 31, 2022, aggregate intrinsic value $ 696,000  
Exercisable at December 31, 2025 (in shares) 1,557,052  
Exercisable at December 31, 2022, weighted average exercise price (in dollars per share) $ 20.18  
Exercisable at December 31, 2022, weighted average contractual term (Year) 6 years 9 months 25 days  
Exercisable at December 31, 2022, aggregate intrinsic value $ 45,000