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Consolidated Statements of Cash Flows - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Cash flows from operating activities:      
Net loss $ (90,973,000) $ (24,342,000) $ (97,217,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock-based compensation 19,582,000 16,291,000 4,586,000
Gain from change in fair value of warrant liabilities (0) (108,183,000) (0)
Depreciation 903,000 952,000 1,084,000
Amortization of intangible assets 33,000 180,000 446,000
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets 6,080,000 539,000 1,714,000
Operating lease right-of-use assets and liabilities 0 0 (17,000)
Accounts payable and other accrued expenses 33,993,000 (2,919,000) 6,896,000
Accrued development expense (2,076,000) (597,000) 757,000
Accrued compensation and benefits 268,000 1,157,000 30,000
Other liabilities (62,000) (7,000) (304,000)
Net cash used in operating activities (32,252,000) (116,929,000) (82,025,000)
Cash flows from investing activities:      
Purchases of property and equipment (581,000) (103,000) (414,000)
Net cash used in investing activities (581,000) (103,000) (414,000)
Cash flows from financing activities:      
Proceeds from issuance of common stock upon exercise of stock options 90,000 918,000 2,560,000
Proceeds from exercise of common stock warrants, net of exercise costs 0 123,552,000 0
Net cash (used in) / provided by financing activities (239,000) 124,470,000 2,560,000
Net increase (decrease) in cash and cash equivalents (33,072,000) 7,438,000 (79,879,000)
Cash and cash equivalents at beginning of period 128,574,000 121,136,000 201,015,000
Cash and cash equivalents at end of period 95,502,000 128,574,000 121,136,000
Non-cash financing activities      
Issuance of warrants resulting in recognition of warrant liabilities 0 113,363,000 0
Derecognition of warrant liabilities upon exercise of warrants 0 (5,180,000) 0
At-the-market 2025 Offering Program [Member]      
Cash flows from financing activities:      
2025 ATM offering program costs $ (329,000) $ 0 $ 0