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v3.22.4

Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities: |  |
Net loss | $ (113,837) | $ (86,075)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Share-based compensation expense | 16,856 | 14,461
Depreciation and amortization expense | 2,637 | 1,756
Accretion of discount and amortization of premium on investments, net | (818) | 3,237
Non-cash lease expense | 3,935 | 367
Realized loss on investments | 490 |
Others |  | (30)
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | (1,489) | (4,435)
Operating lease liabilities | 32,469 |
Accounts payable and accrued and other liabilities | 2,757 | 2,792
Net cash used in operating activities | (57,000) | (67,927)
Cash flows from investing activities: |  |
Purchases of available-for-sale securities | (385,887) | (227,282)
Proceeds from maturities of available-for-sale securities | 248,309 | 264,841
Purchase of property and equipment | (47,111) | (5,025)
Net cash provided by (used in) investing activities | (184,689) | 32,534
Cash flows from financing activities: |  |
Proceeds from secondary offering, net of issuance costs | 215,611 |
Proceeds from ATM offering, net of issuance costs | 1,559 |
Proceeds from ESPP purchases | 445 |
Proceeds from stock option exercises | 1,397 | 1,479
Payments of deferred offering costs |  | (277)
Net cash provided by financing activities | 219,012 | 1,202
Net decrease in cash and cash equivalents | (22,677) | (34,191)
Cash, cash equivalents and restricted cash at beginning of year | 62,914 | 97,105
Cash, cash equivalents and restricted cash at end of year | 40,237 | 62,914
Reconciliation of cash, cash equivalents and restricted cash to the balance sheets: |  |
Cash and cash equivalents | 37,494 | 60,816
Restricted cash | 2,743 | 2,098
Total cash, cash equivalents and restricted cash | 40,237 | 62,914
Supplemental disclosures of non-cash investing and financing activities: |  |
Acquisitions of property and equipment in accounts payable | $ 4,579 | $ 238

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