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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Reconciliation on Income Taxes Amount Computed by Applying Statutory Federal Income Tax Rate to Net Loss

A reconciliation on income taxes to the amount computed by applying the statutory federal income tax rate to the net loss is summarized as follows (in thousands):

		Year Ended December 31,
		2022				2021
Income tax benefit at statutory rates		$	(23,906	)		$	(18,076	)
State income tax, net of federal benefit			(1,566	)			(1,005	)
Permanent items			1,891				592
Research and development credits			(3,426	)			(1,661	)
Other			—				(515	)
Change in valuation allowance			27,007				20,665
Income tax expense		$	—			$	—

Significant Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets are shown below (in thousands):

		December 31,
		2022				2021
Deferred tax assets:
Net operating loss carry forwards		$	36,732			$	33,767
Depreciation and amortization			316				268
Research and development credits			11,999				6,984
Share-based compensation			3,552				2,245
Accrued expenses			1,367				1,189
Lease liability			19,062				2,616
Other, net			35				34
Section 174 Capitalized R&D			17,352				—
Total deferred tax assets			90,415				47,103
Valuation allowance for deferred tax assets			(71,368	)			(44,361	)
Deferred tax assets, net of valuation allowance			19,047				2,742
Deferred tax liabilities:
Right-of-use asset			(18,089	)			(2,471	)
Depreciation and amortization			(958	)			(271	)
Net deferred tax assets		$	—			$	—

Summary of Changes in Gross Unrecognized Tax Benefits

The following table summarizes the changes in the Company’s gross unrecognized tax benefits (in thousands):

		December 31,
		2022				2021
Balance at the beginning of the year		$	1,359			$	777
Increases (decreases) related to tax positions taken in prior years			(43	)			(281	)
Increases related to tax positions taken in current year			1,023				863
Balance at the end of the year		$	2,339			$	1,359

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of the change in unrecognized tax benefits.

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