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CONDENSED STATEMENT OF CASH FLOWS (Unaudited)
 6 Months Ended
Jun. 30, 2023
USD ($)
Jun. 30, 2022
USD ($)
Cash flows from operating activities    
Net loss $ (64,102,000) $ (52,910,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Share-based compensation expense 9,396,000 8,009,000
Depreciation and amortization 1,636,000 1,243,000
Accretion and amortization of premiums and discounts on investments, net (4,511,000) 1,110,000
Realized gain on investments (34,000) 0
Impairment of right-of-use assets 4,100,000  
Non-cash lease expense 1,100,000 2,019,000
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 663,000 3,282,000
Operating lease liabilities 7,143,000 3,649,000
Accounts payable and accrued and other liabilities 2,078,000 (1,274,000)
Net cash used in operating activities (42,531,000) (34,872,000)
Cash flows from investing activities    
Purchases of property and equipment (15,151,000) (4,399,000)
Purchases of investments (157,486,000) (175,011,000)
Maturities of investments 206,395,000 69,088,000
Net cash provided by (used in) investing activities 33,758,000 (110,322,000)
Cash flows from financing activities    
Proceeds from stock option exercises 22,000 413,000
Proceeds from ESPP purchases 374,000  
Proceeds from secondary offering, net of issuance costs   215,611,000
Net cash provided by financing activities 396,000 216,024,000
Net (decrease) increase in cash and cash equivalents (8,377,000) 70,830,000
Cash, cash equivalents, and restricted cash beginning of period 40,237,000 62,914,000
Cash, cash equivalents, and restricted cash end of period 31,860,000 133,744,000
Reconciliation of cash, cash equivalents and restricted cash to the balance sheet:    
Cash and cash equivalents 29,117,000 131,646,000
Restricted cash 2,743,000 2,098,000
Total cash, cash equivalents and restricted cash 31,860,000 133,744,000
Supplemental disclosures of non-cash investing activities:    
Acquisitions of property and equipment in accounts payable $ 690,000 $ 926,000