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Segment Reporting - Summary of Reconciliation to Net Loss (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2025
Jun. 30, 2024
Segment expenses:            
Total operating expenses $ 27,186   $ 30,715   $ 63,750 $ 63,477
Net loss (22,977) $ (31,983) (24,993) $ (29,518) (54,960) (54,511)
Reconciling items:            
Depreciation and amortization (2,331)   (2,262)   (4,630) (4,517)
Share-based compensation (2,053)   (4,414)   (4,887) (8,782)
Interest income 3,970   5,724   8,346 8,970
Other income (expense), net 239   (2)   444 (4)
Segment            
Segment expenses:            
Personnel related expenses, excluding share-based compensation [1] 7,718   9,921   23,615 20,409
Facilities expenses 4,771   4,706   9,336 9,352
Direct external development program expenses 4,850   4,475   10,270 11,068
Other segment expenses [2] 5,463   4,937   11,012 9,349
Total operating expenses 22,802   24,039   54,233 50,178
Net loss $ (22,802)   $ (24,039)   $ (54,233) $ (50,178)
[1] Personnel related expenses include ($0.1) million and $5.0 million of severance and other benefits expense for the three and six months ended June 30, 2025, respectively.
[2] Other segment items include consultants and contractor, lab supplies, and general business expenses.