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v3.25.3

Segment Reporting - Summary of Reconciliation to Net Loss (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Segment expenses: |  |  |  |  |  |  |  |  |
Total operating expenses |  | $ 27,286 |  |  | $ 33,794 |  |  | $ 91,036 | $ 97,271
Reconciling items: |  |  |  |  |  |  |  |  |
Depreciation and amortization |  | (2,306) |  |  | (2,347) |  |  | (6,936) | (6,864)
Share-based compensation |  | (1,773) |  |  | (4,055) |  |  | (6,660) | (12,837)
Impairment of right-of-use asset |  | (791) |  |  | 0 |  |  | (791) | 0
Interest income |  | 3,852 |  |  | 5,453 |  |  | 12,198 | 14,423
Other income (expense), net |  | 1,719 |  |  | (3) |  |  | 2,163 | (7)
Net loss |  | (21,715) | $ (22,977) | $ (31,983) | (28,344) | $ (24,993) | $ (29,518) | (76,675) | (82,855)
Segment |  |  |  |  |  |  |  |  |
Segment expenses: |  |  |  |  |  |  |  |  |
Personnel related expenses, excluding share-based compensation | [1] | 8,125 |  |  | 10,674 |  |  | 31,739 | 31,083
Facilities expenses |  | 5,241 |  |  | 4,683 |  |  | 14,577 | 14,035
Direct external development program expenses |  | 4,644 |  |  | 5,807 |  |  | 14,913 | 16,876
Other segment expenses | [2] | 4,406 |  |  | 6,228 |  |  | 15,420 | 15,576
Total operating expenses |  | 22,416 |  |  | 27,392 |  |  | 76,649 | 77,570
Reconciling items: |  |  |  |  |  |  |  |  |
Net loss |  | $ (22,416) |  |  | $ (27,392) |  |  | $ (76,649) | $ (77,570)
[1] | Personnel related expenses include ($0.1) million and $5.0 million of severance and other benefits expense for the three and nine months ended September 30, 2025, respectively.
[2] | Other segment items include consultants and contractor, lab supplies, and general business expenses.

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