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Segment Reporting (Tables)

9 Months Ended

Sep. 30, 2025

Segment Reporting [Abstract]

Summary of Reconciliation to Net Loss

A reconciliation to the net loss for the three and nine months ended September 30, 2025 and 2024 is included at the bottom of the table below.

		Three Months Ended September 30,								Nine Months Ended September 30,
		2025				2024				2025				2024
Segment expenses:
Personnel related expenses, excluding share-based compensation(1)			8,125				10,674			$	31,739			$	31,083
Facilities expenses			5,241				4,683				14,577				14,035
Direct external development program expenses			4,644				5,807				14,913				16,876
Other segment expenses (2)			4,406				6,228				15,420				15,576
Total segment expenses:			22,416				27,392				76,649				77,570
Segment loss			(22,416	)			(27,392	)			(76,649	)			(77,570	)
Reconciling items:
Depreciation and amortization			(2,306	)			(2,347	)			(6,936	)			(6,864	)
Share-based compensation			(1,773	)			(4,055	)			(6,660	)			(12,837	)
Impairment of right-of-use asset			(791	)			—				(791	)			—
Interest income			3,852				5,453				12,198				14,423
Other income (expense), net			1,719				(3	)			2,163				(7	)
Net loss		$	(21,715	)		$	(28,344	)		$	(76,675	)		$	(82,855	)

(1) Personnel related expenses include ($0.1) million and $5.0 million of severance and other benefits expense for the three and nine months ended September 30, 2025, respectively.

(2) Other segment items include consultants and contractor, lab supplies, and general business expenses.

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- Definition

Tabular disclosure of the reconciliation of profit (loss) from reportable segments to the consolidated income (loss) before income tax expense (benefit) and discontinued operations. Includes, but is not limited to, reconciliation after income tax if income tax is allocated to the reportable segment.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 31
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-31

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-30

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X

- References

No definition available.

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