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Segment Reporting - Summary of Reconciliation to Net Loss (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Segment expenses:                
Total operating expenses $ 27,286     $ 33,794     $ 91,036 $ 97,271
Reconciling items:                
Depreciation and amortization (2,306)     (2,347)     (6,936) (6,864)
Share-based compensation (1,773)     (4,055)     (6,660) (12,837)
Impairment of right-of-use asset (791)     0     (791) 0
Interest income 3,852     5,453     12,198 14,423
Other income (expense), net 1,719     (3)     2,163 (7)
Net loss (21,715) $ (22,977) $ (31,983) (28,344) $ (24,993) $ (29,518) (76,675) (82,855)
Segment                
Segment expenses:                
Personnel related expenses, excluding share-based compensation [1] 8,125     10,674     31,739 31,083
Facilities expenses 5,241     4,683     14,577 14,035
Direct external development program expenses 4,644     5,807     14,913 16,876
Other segment expenses [2] 4,406     6,228     15,420 15,576
Total operating expenses 22,416     27,392     76,649 77,570
Reconciling items:                
Net loss $ (22,416)     $ (27,392)     $ (76,649) $ (77,570)
[1] Personnel related expenses include ($0.1) million and $5.0 million of severance and other benefits expense for the three and nine months ended September 30, 2025, respectively.
[2] Other segment items include consultants and contractor, lab supplies, and general business expenses.