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CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Cash flows from operating activities        
Net loss     $ (76,675,000) $ (82,855,000)
Adjustments to reconcile net loss to net cash used in operating activities:        
Share-based compensation expense $ 1,773,000 $ 4,055,000 6,660,000 12,837,000
Depreciation and amortization 2,306,000 2,347,000 6,936,000 6,864,000
Accretion and amortization of premiums and discounts on investments, net     (3,725,000) (4,978,000)
Realized gain on investments     (43,000) 0
Impairment of right-of-use asset 791,000 0 791,000 0
Non-cash lease expense     1,428,000 1,725,000
Changes in operating assets and liabilities:        
Prepaid expenses and other assets     1,278,000 (3,056,000)
Operating lease liabilities     (3,639,000) (3,469,000)
Accounts payable and accrued and other liabilities     (63,000) (2,013,000)
Net cash used in operating activities     (67,052,000) (74,945,000)
Cash flows from investing activities        
Purchases of property and equipment     (648,000) (3,306,000)
Purchases of investments     (147,149,000) (320,659,000)
Maturities of investments     247,013,000 198,930,000
Net cash provided by (used in) investing activities     99,216,000 (125,035,000)
Cash flows from financing activities        
Proceeds from stock option exercises     0 669,000
Proceeds from ESPP purchases     77,000 158,000
Proceeds from issuance of common stock and pre-funded warrants, net of issuance costs     0 225,073,000
Net cash provided by financing activities     77,000 225,900,000
Net increase in cash and cash equivalents     32,241,000 25,920,000
Cash, cash equivalents, and restricted cash beginning of period     30,616,000 33,783,000
Cash, cash equivalents, and restricted cash end of period 62,857,000 59,703,000 62,857,000 59,703,000
Reconciliation of cash, cash equivalents and restricted cash to the balance sheet:        
Cash and cash equivalents 60,114,000 56,960,000 60,114,000 56,960,000
Restricted cash 2,743,000 2,743,000 2,743,000 2,743,000
Total cash, cash equivalents and restricted cash $ 62,857,000 $ 59,703,000 62,857,000 59,703,000
Supplemental disclosures of non-cash investing and financing activities:        
Right-of-use assets obtained in exchange for operating lease liabilities resulting from new leases     0 579,000
Acquisitions of property and equipment in accounts payable and accrued and other current liabilities     $ 155,000 $ 463,000