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12. Stock-Based Compensation (Details) (USD $) | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011
Number of Shares Outstanding |  |
Number of Outstanding, Ending | 7,524,834 | 6,803,701
Weighted-Average Exercise Price |  |
Weighted Average Exercise Price Outstanding, Ending | $ 0.59 | $ 0.94
Employee stock plans |  |
Shares Available for Grant |  |
Beginning | 1,656,148 | 10,167
Authorized | 1,000,000 | 959,290
Merger with Zymetis, Inc. Plan | (2,555,000) | 323,817
Forfeited/Expired | 1,511,902 | 362,874
Ending | 1,611,134 | 1,656,148
Number of Shares Outstanding |  |
Number of Outstanding, Beginning | 6,803,701 | 5,780,977
Granted | 2,555,000 |
Merger with Zymetis, Inc. Plan |  | 1,421,183
Exercised | (321,965) | (35,585)
Forfeited/Expired | (1,511,902) | (362,874)
Number of Outstanding, Ending | 7,524,834 | 6,803,701
Weighted-Average Exercise Price |  |
Weighted Average Exercise Price Outstanding, Beginning | $ 0.94 | $ 1.02
Merger with Zymetis, Inc. Plan |  | $ 0.41
Granted | $ 0.55 |
Exercised | $ 0.23 | $ 0.06
Forfeited/Expired | $ 2.17 | $ 0.2
Weighted Average Exercise Price Outstanding, Ending | $ 0.59 | $ 0.94

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- Definition The intrinsic value of equity-based payment equity instruments, excluding stock or unit options, granted during the reporting period as calculated by applying the disclosed option pricing methodology. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph c(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph b(2)(c) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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