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12. Stock-Based Compensation (Details) (USD $)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Number of Shares Outstanding    
Number of Outstanding, Ending 7,524,834 6,803,701
Weighted-Average Exercise Price    
Weighted Average Exercise Price Outstanding, Ending $ 0.59 $ 0.94
Employee stock plans
   
Shares Available for Grant    
Beginning 1,656,148 10,167
Authorized 1,000,000 959,290
Merger with Zymetis, Inc. Plan (2,555,000) 323,817
Forfeited/Expired 1,511,902 362,874
Ending 1,611,134 1,656,148
Number of Shares Outstanding    
Number of Outstanding, Beginning 6,803,701 5,780,977
Granted 2,555,000  
Merger with Zymetis, Inc. Plan   1,421,183
Exercised (321,965) (35,585)
Forfeited/Expired (1,511,902) (362,874)
Number of Outstanding, Ending 7,524,834 6,803,701
Weighted-Average Exercise Price    
Weighted Average Exercise Price Outstanding, Beginning $ 0.94 $ 1.02
Merger with Zymetis, Inc. Plan   $ 0.41
Granted $ 0.55  
Exercised $ 0.23 $ 0.06
Forfeited/Expired $ 2.17 $ 0.2
Weighted Average Exercise Price Outstanding, Ending $ 0.59 $ 0.94