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Nature of Activities and Summary of Significant Accounting Policies (Details 2) - shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Total number of potentially dilutive shares excluded from the basic and diluted net loss per share calculation (in thousands) 5,167,000,000 6,852,000,000 5,234,000,000
Series B preferred (post split basis)      
Total number of potentially dilutive shares excluded from the basic and diluted net loss per share calculation (in thousands) 128 132 132
Common stock options and warrants      
Total number of potentially dilutive shares excluded from the basic and diluted net loss per share calculation (in thousands) 3,819 5,422 3,840
Debt with conversion feature at $30 per share of common stock      
Total number of potentially dilutive shares excluded from the basic and diluted net loss per share calculation (in thousands) 1,220 1,298 1,262