<SEC-DOCUMENT>0001129928-17-000003-index.html : 20170328
<SEC-HEADER>0001129928-17-000003.hdr.sgml : 20170328
<ACCEPTANCE-DATETIME>20170327185203
ACCESSION NUMBER:		0001129928-17-000003
CONFORMED SUBMISSION TYPE:	20-F
PUBLIC DOCUMENT COUNT:		18
CONFORMED PERIOD OF REPORT:	20161231
FILED AS OF DATE:		20170328
DATE AS OF CHANGE:		20170327

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ONCOLYTICS BIOTECH INC
		CENTRAL INDEX KEY:			0001129928
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		20-F
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-31062
		FILM NUMBER:		17716446

	BUSINESS ADDRESS:	
		STREET 1:		1167 KENSINGTON CRES NW SUITE 210
		STREET 2:		CALGARY ALBERTA CANADA T2N 1X7
		CITY:			ALBERTA CANADA
		STATE:			A0
		ZIP:			00000
		BUSINESS PHONE:		4036707380

	MAIL ADDRESS:	
		STREET 1:		210 - 1167 KENSINGTON CRES NW
		CITY:			CALGARY
		STATE:			A0
		ZIP:			T2N 1X7
</SEC-HEADER>
<DOCUMENT>
<TYPE>20-F
<SEQUENCE>1
<FILENAME>oncyf2016-20f.htm
<DESCRIPTION>20-F
<TEXT>
Document 1 - file: oncyf2016-20f.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.39
<SEQUENCE>2
<FILENAME>ex439guttierrez.htm
<DESCRIPTION>EXHIBIT 4.39 GUTTIERREZ
<TEXT>
Document 2 - file: ex439guttierrez.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.40
<SEQUENCE>3
<FILENAME>ex440coffey.htm
<DESCRIPTION>EXHIBIT 4.40 COFFEY
<TEXT>
Document 3 - file: ex440coffey.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.41
<SEQUENCE>4
<FILENAME>ex441look.htm
<DESCRIPTION>EXHIBIT 4.41 LOOK
<TEXT>
Document 4 - file: ex441look.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.42
<SEQUENCE>5
<FILENAME>ex442thompson.htm
<DESCRIPTION>EXHIBIT 4.42 THOMPSON
<TEXT>
Document 5 - file: ex442thompson.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-8.0
<SEQUENCE>6
<FILENAME>ex80subsidiaries.htm
<DESCRIPTION>EXHIBIT 8.0 SUBSIDIARIES
<TEXT>
Document 6 - file: ex80subsidiaries.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-12.1
<SEQUENCE>7
<FILENAME>ex121ceocertfication2016.htm
<DESCRIPTION>EXHIBIT 12.1 CEO CERTIFICATION
<TEXT>
Document 7 - file: ex121ceocertfication2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-12.2
<SEQUENCE>8
<FILENAME>ex122cfocertification2016.htm
<DESCRIPTION>EXHIBIT 12.2 CFO CERTIFICATION
<TEXT>
Document 8 - file: ex122cfocertification2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-13.1
<SEQUENCE>9
<FILENAME>ex131ceocertification2016.htm
<DESCRIPTION>EXHIBIT 13.1 CEO CERTIFICATION
<TEXT>
Document 9 - file: ex131ceocertification2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-13.2
<SEQUENCE>10
<FILENAME>ex132cfocertification2016.htm
<DESCRIPTION>EXHIBIT 13.2 CFO CERTIFICATION
<TEXT>
Document 10 - file: ex132cfocertification2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-15.1
<SEQUENCE>11
<FILENAME>ex151-2016mda.htm
<DESCRIPTION>EXHIBIT 15.1 MD&A
<TEXT>
Document 11 - file: ex151-2016mda.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-15.2
<SEQUENCE>12
<FILENAME>ex152eyconsentletter2016.htm
<DESCRIPTION>EXHIBIT 15.2 AUDITOR CONSENT
<TEXT>
Document 12 - file: ex152eyconsentletter2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>eysig1.jpg
<TEXT>
Document 13 - file: eysig1.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>14
<FILENAME>fig2.jpg
<TEXT>
Document 14 - file: fig2.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>15
<FILENAME>figure1a04.jpg
<TEXT>
Document 15 - file: figure1a04.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>16
<FILENAME>image3a01.jpg
<TEXT>
Document 16 - file: image3a01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>17
<FILENAME>logo1.jpg
<TEXT>
Document 17 - file: logo1.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>18
<FILENAME>optiontable.jpg
<TEXT>
Document 18 - file: optiontable.jpg

</DOCUMENT>
</SEC-DOCUMENT>