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CONSOLIDATED STATEMENTS OF LOSS AND COMPREHENSIVE LOSS - CAD ($) | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Expenses |  |  |
Research and development | $ 9,392,623 | $ 9,770,007 | $ 8,601,864
Operating | 6,212,831 | 5,524,500 | 5,315,837
Loss before the following | (15,605,454) | (15,294,507) | (13,917,701)
Interest | 130,101 | 163,902 | 197,859
Loss before income taxes | (15,475,353) | (15,130,605) | (13,719,842)
Income tax expense | (141,498) | (9,374) | (3,153)
Net loss | (15,616,851) | (15,139,979) | (13,722,995)
Other comprehensive (loss) income items that may be reclassified to net loss |  |  |
Translation adjustment | (180,330) | (206,918) | 480,935
Net comprehensive loss | $ (15,797,181) | $ (15,346,897) | $ (13,242,060)
Basic and diluted loss per common share (cad per share) | $ (0.12) | $ (0.13) | $ (0.12)
Weighted average number of shares (basic) | 132,395,752 | 119,880,200 | 112,613,845
Weighted average number of shares (diluted) | 132,395,752 | 119,880,200 | 112,613,845

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