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CONSOLIDATED STATEMENTS OF LOSS AND COMPREHENSIVE LOSS - CAD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Expenses |  |  |
Research and development (note 20) | $ 17,709 | $ 15,432 | $ 12,920
General and administrative (note 20) | 16,082 | 11,492 | 13,315
Loss before the following | (33,791) | (26,924) | (26,235)
Change in fair value of warrant derivative (notes 9, 17) | 5,285 | (20) | 17
Foreign exchange (loss) gain | (475) | 1,665 | (136)
Interest income, net | 1,326 | 528 | 99
Loss before income taxes | (27,655) | (24,751) | (26,255)
Income tax expense (note 15) | (97) | (84) | (49)
Net loss | (27,752) | (24,835) | (26,304)
Other comprehensive (loss) income items that may be reclassified to net loss |  |  |
Translation adjustment | (118) | 274 | (12)
Total comprehensive loss | $ (27,870) | $ (24,561) | $ (26,316)
Basic loss per common share (cad per share) | $ (0.41) | $ (0.43) | $ (0.49)
Diluted loss per common share (cad per share) | $ (0.41) | $ (0.43) | $ (0.49)
Weighted average number of shares (basic) (shares) | 67,624,036 | 58,029,745 | 53,513,225
Weighted average number of shares (diluted) (shares) | 67,624,036 | 58,029,745 | 53,513,225

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