    <SEC-DOCUMENT>0001129928-25-000034-index.html : 20250514
    <SEC-HEADER>0001129928-25-000034.hdr.sgml : 20250514
    <ACCEPTANCE-DATETIME>20250514164854
    ACCESSION NUMBER:		0001129928-25-000034
    CONFORMED SUBMISSION TYPE:	6-K
    PUBLIC DOCUMENT COUNT:		7
    CONFORMED PERIOD OF REPORT:	20250331
    FILED AS OF DATE:		20250514
    DATE AS OF CHANGE:		20250514

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			ONCOLYTICS BIOTECH INC
    		CENTRAL INDEX KEY:			0001129928
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				000000000
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		6-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38512
    		FILM NUMBER:		25946669

    	BUSINESS ADDRESS:
    		STREET 1:		804, 322 - 11 AVENUE SW
    		CITY:			CALGARY
    		STATE:			A0
    		ZIP:			T2R 0C5
    		BUSINESS PHONE:		4036707380

    	MAIL ADDRESS:
    		STREET 1:		804, 322 - 11 AVENUE SW
    		CITY:			CALGARY
    		STATE:			A0
    		ZIP:			T2R 0C5
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>6-K
    <SEQUENCE>1
    <FILENAME>q12025form6-k.htm
    <DESCRIPTION>6-K
    <TEXT>
    Document 1 - file: q12025form6-k.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.1
    <SEQUENCE>2
    <FILENAME>ex991-interimfsmarch312025.htm
    <DESCRIPTION>EX-99.1 2025 FIRST QUARTER INTERIM FINANCIAL STATEMENT
    <TEXT>
    Document 2 - file: ex991-interimfsmarch312025.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.2
    <SEQUENCE>3
    <FILENAME>ex992-q12025mda.htm
    <DESCRIPTION>EX-99.2 2025 FIRST QUARTER MD&A
    <TEXT>
    Document 3 - file: ex992-q12025mda.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.3
    <SEQUENCE>4
    <FILENAME>ex993-q12025certificationx.htm
    <DESCRIPTION>EX-99.3 Q1 2025 CERTIFICATION CEO
    <TEXT>
    Document 4 - file: ex993-q12025certificationx.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.4
    <SEQUENCE>5
    <FILENAME>ex994-q12025certificationx.htm
    <DESCRIPTION>EX-99.4 Q1 2025 CERTIFICATION CFO
    <TEXT>
    Document 5 - file: ex994-q12025certificationx.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>oncolyticslogotaglinebluea.jpg
    <TEXT>
    Document 6 - file: oncolyticslogotaglinebluea.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>pipelinepng.jpg
    <TEXT>
    Document 7 - file: pipelinepng.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>