F-4 F-4/A EX-FILING FEES 333-290954 0001129928 ONCOLYTICS BIOTECH INC N/A Y N 0001129928 2025-12-05 2025-12-05 0001129928 1 2025-12-05 2025-12-05 0001129928 1 2025-12-05 2025-12-05 0001129928 2 2025-12-05 2025-12-05 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables
F-4
ONCOLYTICS BIOTECH INC

Table 1: Newly Registered and Carry Forward Securities | ☐Not Applicable
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|  | Security Type | Security Class Title | Fee Calculation or Carry Forward Rule | Amount Registered | Proposed Maximum Offering Price Per Unit | Maximum Aggregate Offering Price | Fee Rate | Amount of Registration Fee | Carry Forward Form Type | Carry Forward File Number | Carry Forward Initial Effective Date | Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Newly Registered Securities
Fees to be Paid | 1 | Equity | Common Stock, par value $0.001 per share | 457(a) | 150,000,000 | $ 0.90 | $ 135,000,000.00 | 0.0001381 | $ 18,643.50 |  |  |  |
Fees Previously Paid |  |  |  |  |  |  |  |  |  |  |  |  |
Carry Forward Securities
Carry Forward Securities |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | Total Offering Amounts: |  | $ 135,000,000.00 |  | $ 18,643.50 |  |  |  |
|  |  | Total Fees Previously Paid: |  |  |  | $ 0.00 |  |  |  |
|  |  | Total Fee Offsets: |  |  |  | $ 17,067.41 |  |  |  |
|  |  | Net Fee Due: |  |  |  | $ 1,576.09 |  |  |  |

Offering Note |

1 | Includes the shares into which all common shares, no par value, of Oncolytics Biotech Inc. ("Common Shares") that are issued and outstanding immediately prior to the Domestication (as defined in the management circular/prospectus) will be converted in the Domestication. Estimated solely for the purpose of calculating the registration fee, based on the average of the high and low prices of the Common Shares on The Nasdaq Stock Market, LLC on December 3, 2025, in accordance with Rule 457(f)(1).

Table 2: Fee Offset Claims and Sources | ☐Not Applicable
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|  | Registrant or Filer Name | Form or Filing Type | File Number | Initial Filing Date | Filing Date | Fee Offset Claimed | Security Type Associated with Fee Offset Claimed | Security Title Associated with Fee Offset Claimed | Unsold Securities Associated with Fee Offset Claimed | Unsold Aggregate Offering Amount Associated with Fee Offset Claimed | Fee Paid with Fee Offset Source
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Rules 457(b) and 0-11(a)(2)
Fee Offset Claims | 1 |  | F-4 | 333-290954 | 10/20/2025 |  | $ 17,067.41 |  |  |  |  |
Fee Offset Sources |  | Oncolytics Biotech Inc. | F-4 | 333-290954 |  | 10/20/2025 |  |  |  |  |  | $ 17,067.41
Rule 457(p)
Fee Offset Claims |  |  |  |  |  |  |  |  |  |  |  |
Fee Offset Sources |  |  |  |  |  |  |  |  |  |  |  |

Explanation of the basis for claimed offset: |

1 | There were 104,735,039 shares previously registered on the initial filing of this registration statement on Form F-4, filed on October 20, 2025 (File No. 333-290954), for which a registration fee of $17,067.41 was previously paid.

Table 3: Combined Prospectuses | ☑Not Applicable
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| Security Type | Security Class Title | Amount of Securities Previously Registered | Maximum Aggregate Offering Price of Securities Previously Registered | Form Type | File Number | Initial Effective Date
--- | --- | --- | --- | --- | --- | --- | ---
N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A