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Statements of Stockholders' Equity - USD ($) | Total | Series D Convertible Preferred Stock | Series E Convertible Preferred Stock | Preferred Stock | Preferred Stock Series D Convertible Preferred Stock | Preferred Stock Series E Convertible Preferred Stock | Common Stock | Common Stock Series D Convertible Preferred Stock | Common Stock Series E Convertible Preferred Stock | Additional Paid-In Capital | Additional Paid-In Capital Series D Convertible Preferred Stock | Additional Paid-In Capital Series E Convertible Preferred Stock | Service Receivable | Accumulated Deficit | Accumulated Deficit Series D Convertible Preferred Stock | Accumulated Deficit Series E Convertible Preferred Stock
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2018 |  |  |  |  | 60,600 |  |  | 3,831,879 |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2018 |  | $ 10,084,192 |  |  | $ 60 |  |  | $ 7,742 |  |  | $ 202,267,605 |  |  | $ 0 | $ (192,191,215) |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of common stock and warrants, net of expenses (in shares) |  |  |  |  |  |  |  | 1,994,929 |  |  |  |  |  |  |  |  |
Sale of common stock and warrants, net of expenses |  | 8,817,772 |  |  |  |  |  | $ 199 |  |  | 8,817,573 |  |  |  |  |  |
Issuance of common stock, preferred stock and warrants for clinical trial funding commitment, net of expenses and discount (in shares) |  |  |  |  | 200,000 |  |  | 183,334 |  |  |  |  |  |  |  |  |
Issuance of common stock, preferred stock and warrants for clinical trial funding commitment, net of expenses and discount |  | (40,000) |  |  | $ 200 |  |  | $ 110 |  |  | 1,634,690 |  |  | (1,675,000) |  |  |
Stock-based compensation |  | 884,942 |  |  |  |  |  |  |  |  | 884,942 |  |  |  |  |  |
Issuance of common stock upon exercise of warrants (in shares) |  |  |  |  |  |  |  | 2,221,635 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants |  | 3,299,510 |  |  |  |  |  | $ 223 |  |  | 3,299,287 |  |  |  |  |  |
Issuance of common stock upon vesting of restricted stock awards (in shares) |  |  |  |  |  |  |  | 22,057 |  |  |  |  |  |  |  |  |
Issuance of common stock upon vesting of restricted stock awards |  | 0 |  |  |  |  |  | $ 5 |  |  | (5) |  |  |  |  |  |
Deemed dividend recognized on beneficial conversion features of Series C Convertible Preferred Stock issuance |  | 0 |  |  |  |  |  |  |  |  | 268,269 |  |  |  | (268,269) |  |
Issuance of common stock upon conversion of Convertible Preferred Stock (in shares) |  |  |  |  | (200,000) |  |  | 333,333 |  |  |  |  |  |  |  |  |
Issuance of common stock upon conversion of Convertible Preferred Stock |  | 0 |  |  | $ (200) |  |  | $ 33 |  |  | 167 |  |  |  |  |  |
Preferred stock dividend payable on Series A Convertible Preferred Stock |  | (24,240) |  |  |  |  |  |  |  |  |  |  |  |  | (24,240) |  |
Issuance of common stock for share rounding as a result of reverse stock split (in shares) |  |  |  |  |  |  |  | 6,466 |  |  |  |  |  |  |  |  |
Release of clinical trial funding commitment |  | 703,327 |  |  |  |  |  |  |  |  |  |  |  | 703,327 |  |  |
Net loss |  | (16,414,159) |  |  |  |  |  |  |  |  |  |  |  |  | (16,414,159) |  |
Balance (in shares) at Dec. 31, 2019 |  |  |  |  | 60,600 |  |  | 8,593,633 |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2019 |  | 7,311,344 |  |  | $ 60 |  |  | $ 8,312 |  |  | 217,172,528 |  |  | (971,673) | (208,897,883) |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, preferred stock and warrants for clinical trial funding commitment, net of expenses and discount (in shares) |  |  |  |  | 154,670 |  |  | 602,833 |  |  |  |  |  |  |  |  |
Issuance of common stock, preferred stock and warrants for clinical trial funding commitment, net of expenses and discount |  | (7,500) |  |  | $ 15 |  |  | $ 60 |  |  | 2,292,425 |  |  | (2,300,000) |  |  |
Stock-based compensation |  | 1,764,804 |  |  |  |  |  |  |  |  | 1,764,804 |  |  |  |  |  |
Issuance of common stock upon exercise of warrants (in shares) |  |  |  |  |  |  |  | 12,138,469 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants |  | 24,871,586 |  |  |  |  |  | $ 1,214 |  |  | 24,870,372 |  |  |  |  |  |
Issuance of common stock upon vesting of restricted stock awards (in shares) |  |  |  |  |  |  |  | 10,810 |  |  |  |  |  |  |  |  |
Issuance of common stock upon vesting of restricted stock awards |  | 0 |  |  |  |  |  | $ 1 |  |  | (1) |  |  |  |  |  |
Deemed dividend recognized on beneficial conversion features of Series C Convertible Preferred Stock issuance |  |  | $ 0 | $ 0 |  |  |  |  |  |  |  | $ 601,767 | $ 2,664,717 |  |  | $ (601,767) | $ (2,664,717)
Issuance of common stock upon conversion of Convertible Preferred Stock (in shares) |  |  |  |  |  | (154,670) | (210,780) |  | 1,546,700 | 863,852 |  |  |  |  |  |  |
Issuance of common stock upon conversion of Convertible Preferred Stock |  |  | $ 0 | $ 0 |  | $ (15) | $ (210) |  | $ 155 | $ 86 |  | $ (140) | $ 124 |  |  |  |
Preferred stock dividend payable on Series A Convertible Preferred Stock |  | (24,240) |  |  |  |  |  |  |  |  |  |  |  |  | (24,240) |  |
Release of clinical trial funding commitment |  | 1,100,415 |  |  |  |  |  |  |  |  |  |  |  | 1,100,415 |  |  |
Net loss |  | (19,306,672) |  |  |  |  |  |  |  |  |  |  |  |  | (19,306,672) |  |
Sale of stock, shares issued (in shares) | [1] |  |  |  | 865,824 |  |  | 12,964,313 |  |  |  |  |  |  |  |  |
Net proceeds | [1] | 112,299,949 |  |  | $ 866 |  |  | $ 1,297 |  |  | 112,297,786 |  |  |  |  |  |
Common Stock par value adjustment |  | 0 |  |  |  |  |  | $ (7,453) |  |  | 7,453 |  |  |  |  |  |
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  |  |  |  | 60,195 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options |  | 148,196 |  |  |  |  |  | $ 6 |  |  | 148,190 |  |  |  |  |  |
Balance (in shares) at Dec. 31, 2020 |  |  |  |  | 715,644 |  |  | 36,780,805 |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2020 |  | $ 128,157,882 |  |  | $ 716 |  |  | $ 3,678 |  |  | $ 361,820,025 |  |  | $ (2,171,258) | $ (231,495,279) |  |
[1] | Net of expenses of $7,507,123, and fair value of warrants issued as a transaction advisory fee as of the date of issuance of $370,666

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