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Supplementary Balance Sheet Information - Accrued Expenses (Details) - USD ($)	Dec. 31, 2020	Dec. 31, 2019
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accrued compensation	$ 1,523,321	$ 1,003,383
Preferred stock dividend	389,495	365,255
Clinical trials	1,557,134	1,504,660
Clinical trials	66,593	181,408
Director fees	92,500	67,500
Professional fees and outside services	38,180	21,000
Patent, license and other fees	117,440	69,950
Other accrued liabilities	66,100	46,905
Total accrued liabilities	$ 3,850,763	$ 3,260,061

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Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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