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CONDENSED STATEMENT OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Preferred Stock | Preferred Stock Series D Convertible Preferred Stock | Common Stock | Common Stock Series D Convertible Preferred Stock | Additional Paid-In Capital | Additional Paid-In Capital Series D Convertible Preferred Stock | Additional Paid-In Capital Series E Convertible Preferred Stock | Service Receivable | Accumulated Other Comprehensive Income/(Loss) | Accumulated Deficit | Accumulated Deficit Series D Convertible Preferred Stock | Accumulated Deficit Series E Convertible Preferred Stock
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance, beginning (in shares) at Dec. 31, 2019 |  |  | 61,000 |  | 8,594,000 |  |  |  |  |  |  |  |  |
Balance, beginning at Dec. 31, 2019 |  | $ 7,310 | $ 0 |  | $ 8 |  | $ 217,172 |  |  | $ (972) | $ 0 | $ (208,898) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 177 |  |  |  |  | 177 |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants (in shares) |  |  |  |  | 1,610,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants |  | 1,456 |  |  |  |  | 1,456 |  |  |  |  |  |  |
Preferred stock dividend |  | (6) |  |  |  |  |  |  |  |  |  | (6) |  |
Release of clinical trial funding commitment |  | 293 |  |  |  |  |  |  |  | 293 |  |  |  |
Net loss |  | (4,089) |  |  |  |  |  |  |  |  |  | (4,089) |  |
Sale of common stock and warrants (in shares) |  |  |  |  | 800,000 |  |  |  |  |  |  |  |  |
Sale of common stock and warrants |  | 1,000 |  |  |  |  | 1,000 |  |  |  |  |  |  |
Issuance of common stock upon vesting of restricted stock units (in shares) |  |  |  |  | 7,000 |  |  |  |  |  |  |  |  |
Balance, ending (in shares) at Mar. 31, 2020 |  |  | 61,000 |  | 11,011,000 |  |  |  |  |  |  |  |  |
Balance, ending at Mar. 31, 2020 |  | 6,141 | $ 0 |  | $ 8 |  | 219,805 |  |  | (679) | 0 | (212,993) |  |
Balance, beginning (in shares) at Dec. 31, 2019 |  |  | 61,000 |  | 8,594,000 |  |  |  |  |  |  |  |  |
Balance, beginning at Dec. 31, 2019 |  | 7,310 | $ 0 |  | $ 8 |  | 217,172 |  |  | (972) | 0 | (208,898) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  | (12,710) |  |  |  |  |  |  |  |  |  |  |  |
Balance, ending (in shares) at Sep. 30, 2020 |  |  | 927,000 |  | 26,286,000 |  |  |  |  |  |  |  |  |
Balance, ending at Sep. 30, 2020 |  | 33,521 | $ 1 |  | $ 10 |  | 260,807 |  |  | (2,404) | 0 | (224,893) |  |
Balance, beginning (in shares) at Mar. 31, 2020 |  |  | 61,000 |  | 11,011,000 |  |  |  |  |  |  |  |  |
Balance, beginning at Mar. 31, 2020 |  | 6,141 | $ 0 |  | $ 8 |  | 219,805 |  |  | (679) | 0 | (212,993) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 282 |  |  |  |  | 282 |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants (in shares) |  |  |  |  | 3,473,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants |  | 4,605 |  |  |  |  | 4,605 |  |  |  |  |  |  |
Preferred stock dividend |  | (6) |  |  |  |  |  |  |  |  |  | (6) |  |
Release of clinical trial funding commitment |  | 213 |  |  |  |  |  |  |  | 213 |  |  |  |
Net loss |  | (4,124) |  |  |  |  |  |  |  |  |  | (4,124) |  |
Issuance of common stock upon vesting of restricted stock units (in shares) |  |  |  |  | 2,000 |  |  |  |  |  |  |  |  |
Issuance of common stock, preferred stock and warrants for clinical trial funding commitment (in shares) |  |  | 155,000 |  | 603,000 |  |  |  |  |  |  |  |  |
Issuance of common stock, preferred stock and warrants for clinical trial funding commitment |  | (8) |  |  |  |  | 2,292 |  |  | (2,300) |  |  |  |
Deemed dividend |  |  |  |  |  |  |  | $ 602 | $ 2,665 |  |  |  | $ (602) | $ (2,665)
Sale of stock, number of shares issued (in shares) | [1] |  | 866,000 |  | 4,689,000 |  |  |  |  |  |  |  |  |
Proceeds from sale of stock | [1] | 17,279 | $ 1 |  | $ 1 |  | 17,277 |  |  |  |  |  |  |
Issuance of common stock upon conversion of Series D Convertible Preferred Stock (in shares) |  |  |  | (155,000) |  | 1,547,000 |  |  |  |  |  |  |  |
Balance, ending (in shares) at Jun. 30, 2020 |  |  | 927,000 |  | 21,325,000 |  |  |  |  |  |  |  |  |
Balance, ending at Jun. 30, 2020 |  | 24,382 | $ 1 |  | $ 9 |  | 247,528 |  |  | (2,766) | 0 | (220,390) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 362 |  |  |  |  | 362 |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants (in shares) |  |  |  |  | 4,957,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants |  | 12,911 |  |  | $ 1 |  | 12,910 |  |  |  |  |  |  |
Preferred stock dividend |  | (6) |  |  |  |  |  |  |  |  |  | (6) |  |
Release of clinical trial funding commitment |  | 362 |  |  |  |  |  |  |  | 362 |  |  |  |
Net loss |  | (4,497) |  |  |  |  |  |  |  |  |  | (4,497) |  |
Issuance of common stock upon vesting of restricted stock units (in shares) |  |  |  |  | 1,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  | 3,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options |  | 7 |  |  |  |  | 7 |  |  |  |  |  |  |
Balance, ending (in shares) at Sep. 30, 2020 |  |  | 927,000 |  | 26,286,000 |  |  |  |  |  |  |  |  |
Balance, ending at Sep. 30, 2020 |  | 33,521 | $ 1 |  | $ 10 |  | 260,807 |  |  | (2,404) | 0 | (224,893) |  |
Balance, beginning (in shares) at Dec. 31, 2020 |  |  | 716,000 |  | 36,781,000 |  |  |  |  |  |  |  |  |
Balance, beginning at Dec. 31, 2020 |  | 128,158 | $ 1 |  | $ 4 |  | 361,819 |  |  | (2,171) | 0 | (231,495) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 268 |  |  |  |  | 268 |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants (in shares) |  |  |  |  | 771,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants |  | 1,263 |  |  |  |  | 1,263 |  |  |  |  |  |  |
Other comprehensive gain (loss) |  | (67) |  |  |  |  |  |  |  |  | (67) |  |  |
Preferred stock dividend |  | (6) |  |  |  |  |  |  |  |  |  | (6) |  |
Release of clinical trial funding commitment |  | 380 |  |  |  |  |  |  |  | 380 |  |  |  |
Net loss |  | (5,179) |  |  |  |  |  |  |  |  |  | (5,179) |  |
Balance, ending (in shares) at Mar. 31, 2021 |  |  | 716,000 |  | 37,552,000 |  |  |  |  |  |  |  |  |
Balance, ending at Mar. 31, 2021 |  | 124,817 | $ 1 |  | $ 4 |  | 363,350 |  |  | (1,791) | (67) | (236,680) |  |
Balance, beginning (in shares) at Dec. 31, 2020 |  |  | 716,000 |  | 36,781,000 |  |  |  |  |  |  |  |  |
Balance, beginning at Dec. 31, 2020 |  | 128,158 | $ 1 |  | $ 4 |  | 361,819 |  |  | (2,171) | 0 | (231,495) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  | (18,849) |  |  |  |  |  |  |  |  |  |  |  |
Balance, ending (in shares) at Sep. 30, 2021 |  |  | 716,000 |  | 39,552,000 |  |  |  |  |  |  |  |  |
Balance, ending at Sep. 30, 2021 |  | 133,544 | $ 1 |  | $ 4 |  | 384,551 |  |  | (666) | 16 | (250,362) |  |
Balance, beginning (in shares) at Mar. 31, 2021 |  |  | 716,000 |  | 37,552,000 |  |  |  |  |  |  |  |  |
Balance, beginning at Mar. 31, 2021 |  | 124,817 | $ 1 |  | $ 4 |  | 363,350 |  |  | (1,791) | (67) | (236,680) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 1,036 |  |  |  |  | 1,036 |  |  |  |  |  |  |
Other comprehensive gain (loss) |  | 57 |  |  |  |  |  |  |  |  | 57 |  |  |
Preferred stock dividend |  | (6) |  |  |  |  |  |  |  |  |  | (6) |  |
Release of clinical trial funding commitment |  | 546 |  |  |  |  |  |  |  | 546 |  |  |  |
Net loss |  | (6,757) |  |  |  |  |  |  |  |  |  | (6,757) |  |
Sale of common stock, net of expenses (in shares) | [2] |  |  |  | 2,000,000 |  |  |  |  |  |  |  |  |
Sale of common stock, net of expenses | [2] | 19,225 |  |  |  |  | 19,225 |  |  |  |  |  |  |
Balance, ending (in shares) at Jun. 30, 2021 |  |  | 716,000 |  | 39,552,000 |  |  |  |  |  |  |  |  |
Balance, ending at Jun. 30, 2021 |  | 138,918 | $ 1 |  | $ 4 |  | 383,611 |  |  | (1,245) | (10) | (243,443) |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 940 |  |  |  |  | 940 |  |  |  |  |  |  |
Other comprehensive gain (loss) |  | 26 |  |  |  |  |  |  |  |  | 26 |  |  |
Preferred stock dividend |  | (6) |  |  |  |  |  |  |  |  |  | (6) |  |
Release of clinical trial funding commitment |  | 579 |  |  |  |  |  |  |  | 579 |  |  |  |
Net loss |  | (6,913) |  |  |  |  |  |  |  |  |  | (6,913) |  |
Balance, ending (in shares) at Sep. 30, 2021 |  |  | 716,000 |  | 39,552,000 |  |  |  |  |  |  |  |  |
Balance, ending at Sep. 30, 2021 |  | $ 133,544 | $ 1 |  | $ 4 |  | $ 384,551 |  |  | $ (666) | $ 16 | $ (250,362) |  |
[1] | Net of expenses of $0.6 million, and fair value of warrants issued as a transaction advisory fee as of the date of issuance of $0.4 million.
[2] | Net of expenses of $0.8 million.

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