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Summary of Significant Accounting Policies - Antidilutive Securities (Details) - shares
9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 10,742,475 12,844,384
Options to purchase Common Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 3,566,832 1,920,706
Warrants to purchase Common Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 4,490,159 7,373,351
Restricted Stock Units    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 0 991
Series A Convertible Preferred Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 877 877
Series E Convertible Preferred Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 2,684,607 3,548,459