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Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Operating activities |  |
Net loss | $ (28,291) | $ (19,307)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Loss on disposal of assets | 1 | 0
Impairment loss | 0 | 34
Depreciation | 451 | 466
Stock-based compensation expense | 3,234 | 1,765
Amortization of premiums on short-term investments | 1,607 | 0
Change in fair value of derivative financial instruments—warrants | (285) | 281
Release of clinical trial funding commitment | 2,032 | 1,100
Changes in operating assets and liabilities: |  |
Other assets | 166 | (246)
Accounts receivable and unbilled receivable | (215) | (117)
Prepaid expenses and other current assets | (2,099) | (1,100)
Operating lease right-of-use assets | 607 | 320
Accounts payable and accrued expenses | 719 | 1,276
Operating lease liabilities | (811) | (857)
Other liabilities | (156) | 70
Net cash used in operating activities | (23,040) | (16,315)
Investing activities |  |
Capital expenditures | (205) | (211)
Maturities of short-term investments | 28,391 | 0
Purchases of short-term investments | (174,385) | 0
Sales of short-term investments | 14,751 | 0
Net cash used in investing activities | (131,448) | (211)
Financing activities |  |
Proceeds from sale of common stock, preferred stock and warrants, net of expenses of $813 and $7,507 respectively | 34,187 | 112,300
Costs related to the clinical trial funding commitment | 0 | (8)
Proceeds from exercise of warrants | 1,263 | 24,872
Proceeds from exercise of options | 0 | 148
Borrowings under note payable | 0 | 305
Repayments of note payable | 0 | (305)
Net cash provided by financing activities | 35,450 | 137,312
Net change in cash and cash equivalents | (119,038) | 120,786
Cash and cash equivalents—Beginning of period | 130,981 | 10,195
Cash and cash equivalents—End of period | 11,943 | 130,981
Supplementary disclosure of cash flow activity: |  |
Cash paid for taxes | 1 | 1
Acquisition of property and equipment included in accounts payable and accrued liabilities | 6 | 0
Supplemental disclosure of non-cash investing and financing activities: |  |
Preferred stock dividend payable on Series A Convertible Preferred Stock | 24 | 24
Series D Convertible Preferred Stock |  |
Supplemental disclosure of non-cash investing and financing activities: |  |
Deemed dividend recognized on beneficial conversion features of convertible preferred stock | 0 | 602
Common stock, Series D Convertible Preferred Stock and warrants issued in connection with clinical trial funding commitment, net of discount of $0 and $488, respectively | 0 | 2,300
Series E Convertible Preferred Stock |  |
Supplemental disclosure of non-cash investing and financing activities: |  |
Deemed dividend recognized on beneficial conversion features of convertible preferred stock | $ 0 | $ 2,665

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