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Supplementary Balance Sheet Information
12 Months Ended
Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Supplementary Balance Sheet Information Supplementary Balance Sheet Information
Short-term investments available-for-sale securities consist of the following:

As of December 31, 2021
(in thousands)Amortized CostGross Unrealized GainsGross Unrealized LossesFair Market Value
Maturity less than 1 year:
Certificate of deposit$1,260 $— $— $1,260 
Corporate debt securities58,822 (38)58,786 
Commercial paper14,453 (3)14,454 
Non U.S. government728 — — 728 
U.S. treasury securities20,380 — (24)20,356 
Total maturity less than 1 year95,643 (65)95,584 
Maturity 1 to 2 years:
Corporate debt securities29,676 (73)29,604 
U.S. treasury securities3,701 — (11)3,690 
Total maturity 1 to 2 years33,377 (84)33,294 
Total short-term investments$129,020 $$(149)$128,878 

For the year ending December 31, 2021 the realized loss on the sale of short-term investments was $0. The Company did not have short-term investments during the year ending December 31, 2020.

None of the Company’s short-term investments available for sale were in a material unrealized loss position at December 31, 2021. The Company reviewed its investment holdings as of December 31, 2021 and determined that its unrealized losses were not considered to be other-than-temporary based upon (i) the financial strength of the issuing institution and (ii) the fact that no securities have been in an unrealized loss position for twelve months or more. As such, the Company has not recognized any impairment in its financial statements related to its available-for-sale investment securities.

Property and Equipment
Fixed assets consist of furniture and office equipment, leasehold improvements and laboratory equipment. Depreciation expense for property and equipment for the years ended December 31, 2021 and 2020 was $0.5 million and $0.5 million, respectively. Property and equipment consisted of the following:
 As of December 31,
(in thousands)20212020
Furniture and office equipment$955 $798 
Leasehold improvements1,962 1,962 
Laboratory equipment906 868 
 3,823 3,628 
Less—accumulated depreciation(3,441)(3,004)
Property and equipment, net$382 $624 
Accrued Liabilities

Accrued liabilities consisted of the following:

 As of December 31,
(in thousands)20212020
Accrued compensation$1,435 $1,523 
Preferred stock dividend414 390 
Clinical trials1,639 1,557 
Research agreements and services726 67 
Director fees141 93 
Professional fees and outside services63 38 
Patent, license and other fees43 117 
Other accrued liabilities66 66 
Total accrued liabilities$4,527 $3,851