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Basis of Presentation and Summary of Significant Accounting Policies - Anti-dilutive Share Equivalents (Details) - shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Net Loss Per Share    
Antidilutive securities excluded from computation of earnings per share (in shares) 10,947,627 9,807,474
Options to purchase Common Stock    
Net Loss Per Share    
Antidilutive securities excluded from computation of earnings per share (in shares) 3,771,984 1,860,507
Warrants to purchase Common Stock    
Net Loss Per Share    
Antidilutive securities excluded from computation of earnings per share (in shares) 4,490,159 5,260,992
Restricted Stock Units    
Net Loss Per Share    
Antidilutive securities excluded from computation of earnings per share (in shares) 0 491
Series A Convertible Preferred Stock    
Net Loss Per Share    
Antidilutive securities excluded from computation of earnings per share (in shares) 877 877
Series E Convertible Preferred Stock    
Net Loss Per Share    
Antidilutive securities excluded from computation of earnings per share (in shares) 2,684,607 2,684,607