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Supplementary Balance Sheet Information - Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accrued compensation	$ 1,435	$ 1,523
Preferred stock dividend	414	390
Clinical trials	1,639	1,557
Clinical trials	726	67
Director fees	141	93
Professional fees and outside services	63	38
Patent, license and other fees	43	117
Other accrued liabilities	66	66
Total accrued liabilities	$ 4,527	$ 3,851

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Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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