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Stockholders' Equity - Securities Purchase Agreements (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Oct. 02, 2020
May 26, 2020
May 14, 2020
May 14, 2020
May 11, 2020
Apr. 09, 2020
Mar. 30, 2020
Nov. 30, 2021
May 31, 2021
Dec. 31, 2021
 [1]
Dec. 31, 2020
 [2]
Class of Stock [Line Items]                      
Gross proceeds $ 100,900 $ 2,500   $ 810   $ 1,100 $ 1,000 $ 15,000 $ 20,000    
Sale of stock, shares issued (in shares) 6,500,000   146,854   447,761     2,400,000 2,000,000    
Offering price (in dollars per share) $ 13.50   $ 1.43 $ 1.43 $ 1.34            
Net proceeds $ 94,000                 $ 34,187 $ 112,300
Number of days counterparty cannot sell or transfer shares               180 days      
Common Stock                      
Class of Stock [Line Items]                      
Sale of stock, shares issued (in shares)   1,205,400       904,970 800,000        
Over-Allotment Option                      
Class of Stock [Line Items]                      
Sale of stock, shares issued (in shares) 975,000                    
Pre-Funded Warrants                      
Class of Stock [Line Items]                      
Sale of stock, shares issued (in shares)           255,000 131,967        
Series J Warrant                      
Class of Stock [Line Items]                      
Sale of stock, shares issued (in shares)             931,967        
Series L Warrants                      
Class of Stock [Line Items]                      
Sale of stock, shares issued (in shares)           1,159,970          
Series M Warrant                      
Class of Stock [Line Items]                      
Sale of stock, shares issued (in shares)   482,160                  
[1] Net of expenses of $0.8 million.
[2] Net of expenses of $7.5 million, and fair value of warrants issued as a transaction advisory fee as of the date of issuance of $0.4 million.