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Summary of Significant Accounting Policies - Antidilutive Securities (Details) - shares | 3 Months Ended
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Mar. 31, 2022 | Mar. 31, 2021
Net Loss Per Share |  |
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) | 11,300,897 | 9,025,380
Options to purchase Common Stock |  |
Net Loss Per Share |  |
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) | 5,467,611 | 1,849,737
Warrants to purchase Common Stock |  |
Net Loss Per Share |  |
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) | 4,490,159 | 4,490,159
Series A Convertible Preferred Stock |  |
Net Loss Per Share |  |
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) | 877 | 877
Series E Convertible Preferred Stock |  |
Net Loss Per Share |  |
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) | 1,342,250 | 2,684,607

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- Definition Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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