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Stockholders' Equity - Stock Option Activity (Details) - USD ($)
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures      
Authorized shares under the plan (in shares) 3,150,000    
Options to purchase Common Stock      
Weighted-average assumptions      
Risk-free interest rate 1.84%    
Dividend yield (as a percent) 0.00%    
Expected volatility (as a percent) 106.00%    
Expected term 6 years    
Number of Options      
Balance outstanding at the beginning of the period (in shares) 3,771,984    
Granted (in shares) 1,697,536 0  
Cancelled / Forfeited (in shares) (1,109)    
Expired (in shares) (800)    
Balance outstanding at the end of the period (in shares) 5,467,611    
Exercisable at the end of the period (in shares) 1,281,362    
Vested and expected to vest (in shares) 5,331,850    
Weighted Average Exercise Price Per Share      
Balance outstanding at the beginning of the period (in USD per share) $ 7.13    
Granted (in USD per share) 3.19    
Canceled / Forfeited (in USD per share) 31.25    
Expired (in USD per share) 165.84    
Balance outstanding at the end of the period (in USD per share) 5.88    
Exercisable at the end of the period (in USD per share) 8.83    
Vested and expected to vest (in USD per share) $ 5.91    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures      
Options outstanding, intrinsic value $ 65,189   $ 6,405,258
Exercisable at the end of the period, intrinsic value 25,108    
Vested and expected to vest, intrinsic value $ 61,800    
Inducement Grant Stock Options      
Number of Options      
Granted (in shares) 1,120,208    
Equity Incentive Plan 2021      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures      
Number of remaining shares available for issuance (in shares) 918,865