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Supplementary Balance Sheet Information
 6 Months Ended
Jun. 30, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Supplementary Balance Sheet Information Supplementary Balance Sheet Information
Investments available for sale

Investments available for sale consist of the following:

As of June 30,
2022
(in thousands)Amortized CostGross Unrealized GainsGross Unrealized LossesFair Market Value
Maturity less than 1 year:
Certificate of deposit$12,922 $1 $(63)$12,860 
Corporate debt securities59,453 — (626)58,827 
Commercial paper10,228 — (93)10,135 
U.S. treasury securities13,034 — (133)12,901 
Total maturity less than 1 year95,637 1 (915)94,723 
Maturity 1 to 2 years:
Corporate debt securities4,616 — (57)4,559 
U.S. treasury securities1,770 — (11)1,759 
Total maturity 1 to 2 years6,386 — (68)6,318 
Total short-term investments$102,023 $1 $(983)$101,041 


As of December 31, 2021
(in thousands)Amortized CostGross Unrealized GainsGross Unrealized LossesFair Market Value
Maturity less than 1 year:
Certificate of deposit$1,260 $— $— $1,260 
Corporate debt securities58,822 2 (38)58,786 
Commercial paper14,453 4 (3)14,454 
Non U.S. government728 — — 728 
U.S. treasury securities20,380 — (24)20,356 
Total maturity less than 1 year95,643 6 (65)95,584 
Maturity 1 to 2 years:
Corporate debt securities29,676 1 (73)29,604 
U.S. treasury securities3,701 — (11)3,690 
Total maturity 1 to 2 years33,377 1 (84)33,294 
Total short-term investments$129,020 $7 $(149)$128,878 

Unrealized losses in investments available for sale debt securities at June 30, 2022, were primarily due to increases in interest rates, not due to increased credit risks associated with specific securities. We do not intend to sell these investments and it is not more likely than not that we will be required to sell the investments before recovery of their amortized cost bases, which may be at maturity.
Property and equipment

Property and equipment consist of the following:
 
(in thousands)As of June 30,
2022		As of December 31,
2021
Furniture and office equipment$1,212 $955 
Leasehold improvements2,445 1,962 
Laboratory equipment956 906 
4,613 3,823 
Less—accumulated depreciation and amortization(3,475)(3,441)
Property and equipment, net$1,138 $382 

Accrued Liabilities

Accrued liabilities consisted of the following:

(in thousands)As of June 30,
2022		As of December 31,
2021
Accrued compensation$1,304 $1,435 
Preferred stock dividend426 414 
Clinical trials1,780 1,639 
Research agreements and services1,697 726 
Director fees122 141 
Professional fees and outside services28 63 
Patent, license and other fees40 43 
Other accrued liabilities882 66 
Total accrued liabilities$6,279 $4,527