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Summary of Significant Accounting Policies - Antidilutive Securities (Details) - shares
6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 10,964,481 10,142,486
Options to purchase Common Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 5,131,195 2,966,843
Warrants to purchase Common Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 4,490,159 4,490,159
Series A Convertible Preferred Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 877 877
Series E Convertible Preferred Stock    
Net Loss Per Share    
Antidilutive securities excluded from the calculation of basic and diluted loss per share (in shares) 1,342,250 2,684,607