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Stockholders' Equity - Stock Option Activity (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2022
Jun. 30, 2021
Jun. 09, 2022
Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures          
Authorized shares under the plan (in shares)     3,150,000 5,150,000  
Options to purchase Common Stock          
Weighted-average assumptions          
Risk-free interest rate   1.87% 0.94%    
Dividend yield (as a percent)   0.00% 0.00%    
Expected volatility (as a percent)   106.00% 108.00%    
Expected term   6 years 6 years    
Number of Options          
Balance outstanding at the beginning of the period (in shares)   3,771,984      
Granted (in shares)   1,731,136      
Cancelled / Forfeited (in shares)   (371,125)      
Expired (in shares)   (800)      
Balance outstanding at the end of the period (in shares) 5,131,195 5,131,195      
Exercisable at the end of the period (in shares) 2,030,219 2,030,219      
Vested and expected to vest (in shares) 5,042,299 5,042,299      
Weighted Average Exercise Price Per Share          
Balance outstanding at the beginning of the period (in USD per share)   $ 7.13      
Granted (in USD per share)   3.15      
Canceled / Forfeited (in USD per share)   4.77      
Expired (in USD per share)   165.84      
Balance outstanding at the end of the period (in USD per share) $ 5.93 5.93      
Exercisable at the end of the period (in USD per share) 7.49 7.49      
Vested and expected to vest (in USD per share) $ 5.95 $ 5.95      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures          
Options outstanding, intrinsic value $ 80,809 $ 80,809     $ 6,405,258
Exercisable at the end of the period, intrinsic value 34,443 34,443      
Vested and expected to vest, intrinsic value 77,880 $ 77,880      
Incremental reduction of stock compensation expense $ 100,000        
Inducement Grant Stock Options          
Number of Options          
Granted (in shares) 920,208        
Equity Incentive Plan 2021          
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures          
Number of remaining shares available for issuance (in shares) 3,055,281 3,055,281