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Supplementary Balance Sheet Information
 9 Months Ended
Sep. 30, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Supplementary Balance Sheet Information Supplementary Balance Sheet Information
Investments available for sale

Investments available for sale consist of the following:

As of September 30,
2022
(in thousands)Amortized CostGross Unrealized GainsGross Unrealized LossesFair Market Value
Maturity less than 1 year:
Certificate of deposit$14,285 $4 $(87)$14,202 
Corporate debt securities49,055 3 (498)48,560 
Commercial paper10,528 4 (49)10,483 
U.S. treasury securities15,348 — (94)15,254 
Total maturity less than 1 year89,216 11 (728)88,499 
Maturity 1 to 2 years:
Corporate debt securities7,148 4 (65)7,087 
U.S. treasury securities— — — — 
Total maturity 1 to 2 years7,148 4 (65)7,087 
Total short-term investments$96,364 $15 $(793)$95,586 


As of December 31, 2021
(in thousands)Amortized CostGross Unrealized GainsGross Unrealized LossesFair Market Value
Maturity less than 1 year:
Certificate of deposit$1,260 $— $— $1,260 
Corporate debt securities58,822 2 (38)58,786 
Commercial paper14,453 4 (3)14,454 
Non U.S. government728 — — 728 
U.S. treasury securities20,380 — (24)20,356 
Total maturity less than 1 year95,643 6 (65)95,584 
Maturity 1 to 2 years:
Corporate debt securities29,676 1 (73)29,604 
U.S. treasury securities3,701 — (11)3,690 
Total maturity 1 to 2 years33,377 1 (84)33,294 
Total short-term investments$129,020 $7 $(149)$128,878 

Unrealized losses in investments available for sale debt securities at September 30, 2022, were primarily due to increases in interest rates, not due to increased credit risks associated with specific securities. We do not intend to sell these investments and it is not more likely than not that we will be required to sell the investments before recovery of their amortized cost bases, which may be at maturity.
Investments available for sale that have been in a continuous unrealized loss position for greater than one-year consist of the following:
As of September 30,
2022
(in thousands)Fair Market ValueGross Unrealized Loss
Corporate debt securities751 (6)
U.S. treasury securities1,839 (22)
Total short-term investments$2,590 $(28)

Property and equipment

Property and equipment consist of the following:
 
(in thousands)As of September 30,
2022		As of December 31,
2021
Furniture and office equipment$1,069 $955 
Leasehold improvements2,545 1,962 
Laboratory equipment1,019 906 
4,633 3,823 
Less—accumulated depreciation and amortization(3,329)(3,441)
Property and equipment, net$1,304 $382 

Accrued Liabilities

Accrued liabilities consisted of the following:

(in thousands)As of September 30,
2022		As of December 31,
2021
Accrued compensation$1,609 $1,435 
Preferred stock dividend432 414 
Clinical trials2,132 1,639 
Research agreements and services1,125 726 
Director fees125 141 
Professional fees and outside services29 63 
Patent, license and other fees122 43 
Other accrued liabilities564 66 
Total accrued liabilities$6,138 $4,527