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Stockholders' Equity - Stock Option Activity (Details) - USD ($)
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Jun. 09, 2022
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures        
Authorized shares under the plan (in shares)   3,150,000   5,150,000
Options to purchase Common Stock        
Weighted-average assumptions        
Risk-free interest rate 3.58% 1.84%    
Dividend yield (as a percent) 0.00% 0.00%    
Expected volatility (as a percent) 110.00% 106.00%    
Expected term(1) 5 years 3 months 18 days 6 years    
Number of Options        
Balance outstanding at the beginning of the period (in shares) 5,069,458      
Granted (in shares) 1,806,008      
Cancelled / Forfeited (in shares) (1,725)      
Expired (in shares) (476,846)      
Balance outstanding at the end of the period (in shares) 6,396,895      
Exercisable at the end of the period (in shares) 2,427,304      
Vested and expected to vest (in shares) 6,187,656      
Weighted Average Exercise Price Per Share        
Balance outstanding at the beginning of the period (in USD per share) $ 5.92      
Granted (in USD per share) 1.73      
Canceled / Forfeited (in USD per share) 7.98      
Expired (in USD per share) 6.93      
Balance outstanding at the end of the period (in USD per share) 4.66      
Exercisable at the end of the period (in USD per share) 6.57      
Vested and expected to vest (in USD per share) $ 4.73      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures        
Options outstanding, intrinsic value $ 34,107   $ 19,322  
Exercisable at the end of the period, intrinsic value 20,517      
Vested and expected to vest, intrinsic value $ 33,160      
Inducement Grant Stock Options        
Number of Options        
Granted (in shares) 1,345,208      
Equity Incentive Plan 2021        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures        
Number of remaining shares available for issuance (in shares) 2,180,898