<SEC-DOCUMENT>0001831942-25-000010.txt : 20250814
<SEC-HEADER>0001831942-25-000010.hdr.sgml : 20250814
<ACCEPTANCE-DATETIME>20250814170619
ACCESSION NUMBER:		0001831942-25-000010
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250814
DATE AS OF CHANGE:		20250814

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cardiff Oncology, Inc.
		CENTRAL INDEX KEY:			0001213037
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				272004382
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-80378
		FILM NUMBER:		251220818

	BUSINESS ADDRESS:	
		STREET 1:		11055 FLINTKOTE AVENUE
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		858-952-7570

	MAIL ADDRESS:	
		STREET 1:		11055 FLINTKOTE AVENUE
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Trovagene, Inc.
		DATE OF NAME CHANGE:	20130304

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TrovaGene Inc.
		DATE OF NAME CHANGE:	20110830

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	XENOMICS INC
		DATE OF NAME CHANGE:	20040719

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Commodore Capital LP
		CENTRAL INDEX KEY:			0001831942
		ORGANIZATION NAME:           	
		EIN:				832659606
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		444 MADISON AVENUE
		STREET 2:		35TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-256-8600

	MAIL ADDRESS:	
		STREET 1:		444 MADISON AVENUE
		STREET 2:		35TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	COMMODORE CAPITAL LP
		DATE OF NAME CHANGE:	20201110
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      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001213037</issuerCik>
        <issuerName>Cardiff Oncology, Inc.</issuerName>
        <issuerCusip>14147L108</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>11055 Flintkote Avenue</com:street1>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92121</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
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        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
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      <reportingPersonName>Commodore Capital LP</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
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      <reportingPersonName>Commodore Capital Master LP</reportingPersonName>
      <citizenshipOrOrganization>E9</citizenshipOrOrganization>
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      <item1>
        <issuerName>Cardiff Oncology, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>11055 Flintkote Avenue, San Diego, CALIFORNIA, 92121.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Commodore Capital LP
Commodore Capital Master LP

Each a "Filer."</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address for Commodore Capital LP is 444 Madison Avenue, Floor 35, New York, NY 10022.

The address for Commodore Capital Master LP is c/o Maples Corporate Services Limited, Ugland House, South Church Street, PO Box 309, Grand Cayman KY1-1104, Cayman Islands.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>See Item 4 of the cover page for each Filer.</citizenship>
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      <item3>
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      <item4>
        <amountBeneficiallyOwned>See Item 9 of the cover page for each Filer.</amountBeneficiallyOwned>
        <classPercent>See Item 11 of the cover page for each Filer.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>See Item 5 of the cover page for each Filer.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>See Item 6 of the cover page for each Filer.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>See Item 7 of the cover page for each Filer.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>See Item 8 of the cover page for each Filer.</sharedPowerOrDirectToDispose>
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      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit 1: Joint Filing Agreement</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>Commodore Capital LP</reportingPersonName>
      <signatureDetails>
        <signature>Michael Kramarz</signature>
        <title>Managing Partner</title>
        <date>08/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Commodore Capital Master LP</reportingPersonName>
      <signatureDetails>
        <signature>Michael Kramarz</signature>
        <title>Authorized Signatory</title>
        <date>08/14/2025</date>
      </signatureDetails>
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<FILENAME>exhibit1jointfilingagreement.htm
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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: right">Exhibit 1</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><B>JOINT FILING AGREEMENT</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">The undersigned acknowledge and agree that the foregoing statement on Schedule
13G is filed on behalf of each of the undersigned, and that all subsequent amendments to this statement on Schedule 13G shall be filed
on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The undersigned acknowledge
that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning
it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the other, except to
the extent that it knows or has reason to believe that such information is inaccurate.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">Dated: August 14, 2025</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">By: <B>Commodore Capital LP</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">By: <U>/s/Michael Kramarz</U></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">Name: Michael Kramarz</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">Title: Managing Partner</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">By: <B>Commodore Capital Master LP</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">By: <U>/s/Michael Kramarz </U></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">Name: Michael Kramarz</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">Title: Authorized Signatory</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 3.5in">&nbsp;</P>

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