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License Agreements - Additional Information (Details) - USD ($)
1 Months Ended 12 Months Ended
Apr. 30, 2021
Mar. 31, 2021
Dec. 31, 2020
Apr. 30, 2020
Dec. 31, 2021
Dec. 31, 2020
Jan. 31, 2021
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Research and development expense         $ 51,054,000 $ 9,048,000  
Proceeds from stock options exercised         167,000 32,000  
Accounts payable     $ 1,077,000   11,951,000 $ 1,077,000  
Pfizer License Agreement              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Research and development expense         25,000,000.0    
Royalty obligation period for licensed products upon first commercial sale     12 years        
Milestone and royalties required         0    
Upfront payments         5,000,000.0    
Sublicensing revenue percentage     30.00%     30.00%  
One-time payment         0    
Pfizer License Agreement | Research and Development Expenses              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Payment for license fee         $ 25,000,000.0    
Pfizer License Agreement | Maximum              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Aggregate milestone payments for first four licensed products     $ 660,000,000        
One-time payment     $ 20,000,000.0     $ 20,000,000.0  
Pfizer License Agreement | Series B Convertible Preferred Stock              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Issuance of convertible preferred stock shares         12,152,145    
Issuance of convertible preferred stock value         $ 20,000,000.0    
LegoChem License Agreement              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Research and development expense         0    
Royalty obligation period for licensed products upon first commercial sale     10 years        
Milestone and royalties required     $ 0   0 0  
Upfront payments   $ 500,000       5,000,000.0  
Payments to purchase licensed products     500,000   9,000,000.0    
Licensed product estimated cost     7,000,000.0     7,000,000.0  
Proceeds from stock options exercised $ 8,000,000.0            
Extra Milestone Payment       $ 9,600,000      
Accounts payable         9,600,000    
Derivative liability             $ 3,400,000
LegoChem License Agreement | Research and Development Expenses              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Upfront payments         9,000,000.0 500,000  
LegoChem License Agreement | Maximum              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Milestone payments payable upon certain achievements     284,500,000        
LegoChem License Agreement | Series B Convertible Preferred Stock              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Issuance of convertible preferred stock shares   303,804          
University License Agreement              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Stock issued       48,919      
Research and development expense         0 3,000  
Annual maintenance fee       $ 10,000      
Royalty obligation period for licensed products upon first commercial sale       10 years      
Milestone and royalties required     $ 0   $ 0 $ 0  
University License Agreement | Maximum              
Research And Development Arrangement Contract To Perform For Others [Line Items]              
Potential development and commercial milestones       $ 7,700,000      
Minimum annual royalty fees       $ 3,000,000.0