<SEC-DOCUMENT>0001567619-22-015316.txt : 20220809
<SEC-HEADER>0001567619-22-015316.hdr.sgml : 20220809
<ACCEPTANCE-DATETIME>20220809163438
ACCESSION NUMBER:		0001567619-22-015316
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20220803
FILED AS OF DATE:		20220809
DATE AS OF CHANGE:		20220809

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Wadhane Jitendra
		CENTRAL INDEX KEY:			0001941706

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40881
		FILM NUMBER:		221148914

	MAIL ADDRESS:	
		STREET 1:		35 CAMBRIDGE PARK DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02140

	FORMER NAME:	
		FORMER CONFORMED NAME:	Wadhane Jitu
		DATE OF NAME CHANGE:	20220808

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Pyxis Oncology, Inc.
		CENTRAL INDEX KEY:			0001782223
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				831160910
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		35 CAMBRIDGE PARK DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02140
		BUSINESS PHONE:		(617) 221-9059

	MAIL ADDRESS:	
		STREET 1:		35 CAMBRIDGE PARK DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02140
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<DESCRIPTION>FORM 3
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    <periodOfReport>2022-08-03</periodOfReport>

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    <issuer>
        <issuerCik>0001782223</issuerCik>
        <issuerName>Pyxis Oncology, Inc.</issuerName>
        <issuerTradingSymbol>PYXS</issuerTradingSymbol>
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            <rptOwnerName>Wadhane Jitendra</rptOwnerName>
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            <rptOwnerStreet1>C/O PYXIS ONCOLOGY, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>150 CAMBRIDGEPARK DRIVE</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02140</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP, Chief Accounting Officer</officerTitle>
            <otherText></otherText>
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            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>43648</value>
                    <footnoteId id="F1"/>
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            <securityTitle>
                <value>Stock Option (Right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>8.71</value>
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            <exerciseDate>
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            <expirationDate>
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        <footnote id="F1">Represents restricted stock units that vest 25% on March 31, 2023, and then in 36 substantially-equal monthly installments thereafter, subject to the reporting person's continued employment through the applicable vesting date.</footnote>
        <footnote id="F2">These stock options vest 25% on August 23, 2022, and then in 36 substantially-equal monthly installments thereafter, subject to the reporting person's continued employment through the applicable vesting date.</footnote>
    </footnotes>

    <remarks>Exhibit List: Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Pamela Connealy, Attorney-in-Fact for Jitendra Wadhane</signatureName>
        <signatureDate>2022-08-09</signatureDate>
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    <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY</div>
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    <div style="text-indent: 36pt;">Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of <u>Pamela Connealy</u> of Pyxis Oncology, Inc. <font style="color: #1F1F1F;">(the &#8220;Company&#8221;)</font> and <u>Asher Rubin</u> of Sidley Austin LLP, or either of them acting individually, and with full power of substitution, the undersigned's true and lawful attorney-in-fact to:</div>
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          <td style="width: 31.5pt; vertical-align: top; align: right; color: #1F1F1F;">(1)</td>
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            <div style="color: #1F1F1F;">prepare, execute in the undersigned's name and on the undersigned's behalf, and submit to the U.S. Securities and Exchange Commission (the "SEC") a Form
              ID, including amendments thereto, and any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings with the SEC of reports required by Section 16(a) of the Securities Exchange
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          <td style="width: 31.5pt; vertical-align: top; align: right; color: #1F1F1F;">(2)</td>
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            <div style="color: #1F1F1F;">execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of the Company, Forms 3, 4, and 5, including
              amendments thereto, in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules and regulations thereunder;</div>
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          <td style="width: 31.5pt; vertical-align: top; align: right;">(3)</td>
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            <div style="color: #1F1F1F;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or
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            <div style="color: #1F1F1F;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in
              the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain
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    <div>&#160;</div>
    <div style="text-indent: 36pt; color: #1F1F1F;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act
      and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of
      substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers
      herein granted. The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with
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    <div style="text-indent: 36pt;"><font style="color: #1F1F1F;">This Power of Attorney shall remain in full
        force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier (a) revoked by the undersigned </font><font style="color: #3F3F3F;">i</font><font style="color: #1F1F1F;">n a signed writing delivered to the foregoing
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    <div style="text-indent: 36pt; color: #1F1F1F;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this</div>
    <div>3rd <font style="color: #1F1F1F;">day of </font>August,<font style="color: #1F1F1F;"> 2022.</font></div>
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            <td style="width: 25%; text-align: center;"><font style="font-family: 'Times New Roman',Times,serif;"><u>Jitendra Wadhane</u></font></td>
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