<SEC-DOCUMENT>0001140361-22-029665.txt : 20220815
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<ACCEPTANCE-DATETIME>20220815173151
ACCESSION NUMBER:		0001140361-22-029665
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20220811
FILED AS OF DATE:		20220815
DATE AS OF CHANGE:		20220815

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			HUMPHREY RACHEL
		CENTRAL INDEX KEY:			0001579781

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40881
		FILM NUMBER:		221166943

	MAIL ADDRESS:	
		STREET 1:		C/O MIRATI THERAPEUTICS INC.
		STREET 2:		4660 LA JOLLA VILLAGE DRIVE, SUITE 500
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Pyxis Oncology, Inc.
		CENTRAL INDEX KEY:			0001782223
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				831160910
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		35 CAMBRIDGE PARK DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02140
		BUSINESS PHONE:		(617) 221-9059

	MAIL ADDRESS:	
		STREET 1:		35 CAMBRIDGE PARK DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02140
</SEC-HEADER>
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<TYPE>3
<SEQUENCE>1
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<DESCRIPTION>FORM 3
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        <issuerName>Pyxis Oncology, Inc.</issuerName>
        <issuerTradingSymbol>PYXS</issuerTradingSymbol>
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            <rptOwnerName>HUMPHREY RACHEL</rptOwnerName>
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            <rptOwnerStreet1>C/O PYXIS ONCOLOGY, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>150 CAMBRIDGEPARK DRIVE</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02140</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isDirector>true</isDirector>
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    <remarks>Exhibit List: Exhibit 24 - Power of Attorney</remarks>

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        <signatureName>/s/ Pamela Connealy, Attorney-in-Fact for Rachel Humphrey</signatureName>
        <signatureDate>2022-08-15</signatureDate>
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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>brhc10040832_ex24.htm
<DESCRIPTION>EXHIBIT 24
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  <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 24</font><br>
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    <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of <u>Pamela Connealy</u> and <u>Jitendra Wadhane</u> of Pyxis Oncology, Inc. <font style="color: #1F1F1F;">(the &#8220;Company&#8221;)</font>,
      and <u>Asher Rubin</u> of Sidley Austin LLP, or any of them acting individually, and with full power of substitution, the undersigned's true and lawful attorney-in-fact to:</div>
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          <td style="width: 31.5pt; vertical-align: top; align: right; color: #1F1F1F;">(1)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #1F1F1F;">prepare, execute in the undersigned's name and on the undersigned's behalf, and submit to the U.S. Securities and Exchange Commission (the "SEC") a Form ID, including amendments thereto, and any other documents
              necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings with the SEC of reports required by Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation of the SEC;</div>
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    <div>&#160;</div>
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          <td style="width: 31.5pt; vertical-align: top; align: right; color: #1F1F1F;">(2)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #1F1F1F;">execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of the Company, Forms 3, 4, and 5, including amendments thereto, in accordance with Section 16(a) of the
              Securities Exchange Act of 1934 and the rules and regulations thereunder;</div>
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    <div>&#160;</div>
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          <td style="width: 31.5pt; vertical-align: top; align: right;">(3)</td>
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            <div style="color: #1F1F1F;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or 5, complete and execute any amendment or amendments thereto,
              and timely file such form with the SEC and any stock exchange or similar authority; and</div>
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    <div>&#160;</div>
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          <td style="width: 31.5pt; vertical-align: top; align: right;">(4)</td>
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            <div style="color: #1F1F1F;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned,
              it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in
              such attorney-in-fact's discretion.</div>
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    <div>&#160;</div>
    <div style="text-indent: 36pt; color: #1F1F1F;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of
      any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such
      attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The undersigned acknowledges that the foregoing
      attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with Section 16 of the Securities Exchange Act of 1934.</div>
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    <div style="text-indent: 36pt;"><font style="color: #1F1F1F;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and
        transactions in securities issued by the Company, unless earlier (a) revoked by the undersigned </font><font style="color: #3F3F3F;">i</font><font style="color: #1F1F1F;">n a signed writing delivered to the foregoing attorneys-in-fact or (b)
        superseded by a new power of attorney regarding the purposes outlined herein at a later date.</font></div>
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    <div style="text-indent: 36pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 9th <font style="color: rgb(31, 31, 31);">day of </font>August,<font style="color: rgb(31, 31, 31);"> 2022.</font></div>
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            <div style="text-align: center; color: rgb(31, 31, 31);">/s/ Rachel Humphrey</div>
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            <div style="text-align: center; color: rgb(31, 31, 31);">Signature</div>
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            <div style="text-align: center;"><u>Rachel W. Humphrey</u></div>
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            <div style="text-align: center; color: rgb(31, 31, 31);">Print Name</div>
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