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Document And Entity Information
 12 Months Ended
Dec. 31, 2025
Document Information [Line Items]  
Document Type S-3
Entity Registrant Name PYXIS ONCOLOGY, INC
Entity Incorporation, State or Country Code DE
Entity Tax Identification Number 83-1160910
Entity Address, Address Line One 321 Harrison Avenue
Entity Address, City or Town Boston
Entity Address, State or Province MA
Entity Address, Postal Zip Code 02118
City Area Code 617
Local Phone Number 453-3596
Entity Filer Category Non-accelerated Filer
Entity Small Business true
Entity Emerging Growth Company true
Entity Ex Transition Period true
Entity Central Index Key 0001782223
Document Fiscal Year Focus 2025
Document Fiscal Period Focus FY
Amendment Flag false