    <SEC-DOCUMENT>0001193125-26-194032-index.html : 20260430
    <SEC-HEADER>0001193125-26-194032.hdr.sgml : 20260430
    <ACCEPTANCE-DATETIME>20260430073552
    ACCESSION NUMBER:		0001193125-26-194032
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		5
    CONFORMED PERIOD OF REPORT:	20260430
    FILED AS OF DATE:		20260430
    DATE AS OF CHANGE:		20260430

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Pyxis Oncology, Inc.
    		CENTRAL INDEX KEY:			0001782223
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				831160910
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40881
    		FILM NUMBER:		26920112

    	BUSINESS ADDRESS:
    		STREET 1:		321 HARRISON AVENUE
    		CITY:			BOSTON
    		STATE:			MA
    		ZIP:			02118
    		BUSINESS PHONE:		(617) 221-9059

    	MAIL ADDRESS:
    		STREET 1:		321 HARRISON AVENUE
    		CITY:			BOSTON
    		STATE:			MA
    		ZIP:			02118
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>2026_pyxs-14a.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: 2026_pyxs-14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>img251211442_0.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: img251211442_0.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>img251211442_1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: img251211442_1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>img251211442_2.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: img251211442_2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>img251211442_3.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: img251211442_3.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>