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<SEC-DOCUMENT>0001178913-07-002780.txt : 20071220
<SEC-HEADER>0001178913-07-002780.hdr.sgml : 20071220
<ACCEPTANCE-DATETIME>20071220070541
ACCESSION NUMBER:		0001178913-07-002780
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20071220
FILED AS OF DATE:		20071220
DATE AS OF CHANGE:		20071220

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		071317765

	BUSINESS ADDRESS:	
		STREET 1:		72 PINCHAS ROSEN ST
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			69512
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		72 PINCHAS ROSEN ST
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			69512
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk74624.htm
<TEXT>
<HTML>
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     <!-- Control Number: 74624                                                            -->
     <!-- Rev Number:     1                                                                -->
     <!-- Client Name:    Compugen Ltd                                                     -->
     <!-- Project Name:   6-K                                                              -->
     <!-- Firm Name:      Zadok-Keinan Ltd                                                 -->
     <TITLE>6-K</TITLE>
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<P ALIGN="Center"><FONT FACE="Times New Roman, Times, Serif" SIZE="4"><B>FORM
6-K<BR>
SECURITIES
AND EXCHANGE COMMISSION</B> </FONT></P>

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<P ALIGN="Center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>Washington,
D.C. 20549</B> </FONT></P>

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<P ALIGN="Center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>Report
of Foreign Private Issuer</B> </FONT></P>

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<P ALIGN="Center"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant
to rule 13a-16 or 15d-16 of the Securities Exchange Act of 1934 <BR>
for the month of
December 2007 </FONT></P>

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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="5"><U><B>Compugen Ltd.</B></U> </FONT> <BR>
<FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Translation of
registrant&#146;s name in English) </FONT></P>

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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2><U>72 Pinchas Rosen
Street, Tel-Aviv 69512, Israel </U><BR>
(Address of principal
executive offices) </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Indicate by check mark whether the
registrant files or will file annual reports under cover Form 20-F or Form 40-F. </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Minor Center-TNR" FSL="Workstation" -->
<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Form 20-F <FONT size="3" face="Wingdings">x
</font> Form 40-F <FONT size="3" face="Wingdings">o
</font></FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>On December 20, 2007 Compugen Ltd.
(the &#147;Registrant&#148;) issued a Press Release, filed as Exhibit 1 to this Report on
Form 6-K, which is hereby incorporated by reference herein. </FONT></P>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>SIGNATURE</U> </FONT> </H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant to the requirements of the
Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed
on its behalf by the undersigned, thereunto duly authorized. </FONT></P>









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<TR VALIGN=TOP>
<TD WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=50%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Compugen Ltd.<BR>
(Registrant)<BR><BR>
<BR>By:    /s/ Ronit Lerner<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Ronit Lerner<BR>Chief Financial Officer<BR>
Date: December 20, 2007</FONT></TD>
</TR>
</TABLE>
<BR>

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<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>2
<FILENAME>exhibit_1.htm
<TEXT>
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     <!-- Project:        F:\EDGAR Filing\Compugen Ltd\74624\a74624.eep                    -->
     <!-- Control Number: 74624                                                            -->
     <!-- Rev Number:     1                                                                -->
     <!-- Client Name:    Compugen Ltd                                                     -->
     <!-- Project Name:   6-K                                                              -->
     <!-- Firm Name:      Zadok-Keinan Ltd                                                 -->
     <TITLE>6-K</TITLE>
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<P ALIGN="Right"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U><B>Exhibit 1</B></U> </FONT> </P>

<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2><IMG SRC="compugen.jpg"></FONT></P>



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<H1 ALIGN="Center"><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Compugen
and Roche sign Agreement to Identify Genetic Variations <BR>
Predictive of Drug Response in Rheumatoid Arthritis
Patients </FONT></H1>

<!-- MARKER FORMAT-SHEET="Head Minor Center-TNR" FSL="Workstation" -->
<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B><I>Collaboration to be
based on Compugen&#146;s GeneVa Platform</I></B> </FONT> </P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Tel Aviv, Israel &#150; December 20,
2007 &#150; Compugen Ltd. (NASDAQ: CGEN) announced today that it has signed a
collaborative discovery and license agreement with Roche. The collaboration will cover the
identification and validation of genetic variations for the prediction of response to
drugs used for the treatment of rheumatoid arthritis. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>According to the agreement, Compugen,
utilizing its proprietary GeneVa platform, will analyze DNA samples and clinical data
provided by Roche, in order to identify and validate non-SNP (single nucleotide
polymorphism) genetic variations that could serve as biomarkers for the predicted response
or non-response to selected drugs for treatment of rheumatoid arthritis. Financial terms
of the agreement were not disclosed. </FONT></P>

<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Rheumatoid arthritis is a common
autoimmune disease that causes chronic inflammation of the joints, affecting more than 21
million people worldwide. Typically, rheumatoid arthritis is a progressive illness that
has the potential to cause joint destruction and functional disability. While there has
been substantial progress in treating this disease through the introduction of new drugs,
these drugs can result in serious side effects, are not effective for all patients, and
can often take months of usage to determine whether or not they are appropriate in
individual cases. This collaboration aims to address the difficult and important clinical
challenge of selecting the right drug for the right patient. </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Major Left Bold-TNR" FSL="Workstation" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>About Compugen&#146;s
GeneVa Platform</B> <BR>
Compugen&#146;s GeneVa platform
incorporates an <I>in silico</I> database of approximately 200,000 predicted non-SNP
genetic variations, including insertions, deletions and copy-number variations in the
human genome. GeneVa utilizes special purpose algorithms and other computational biology
tools to select from this database those genetic variations that are predicted to be
associated with the specific clinical phenotypes of interest, such as response or
non-response to a specified drug of interest, or predisposition to a specified disease.
Another key feature of the platform is a proprietary genotyping capability that allows the
testing of multiple genetic variations on hundreds of DNA samples in a precise and
cost-effective manner. </FONT></P>

<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&#147;This agreement is both the
first based on our GeneVa platform and also our first collaboration with Roche, one of the
world&#146;s leading research-focused healthcare groups in the fields of pharmaceuticals
and diagnostics,&#148; stated Alex Kotzer, President and Chief Executive Officer of
Compugen. &#147;Looking to the future, we believe that our GeneVa platform will prove to
be a key addition to ongoing worldwide efforts towards more personalized medicine and
tools for the accurate assessment of individual predisposition to various diseases and
other medical conditions, thereby allowing earlier and more appropriate
intervention,&#148; Mr. Kotzer concluded. </FONT></P>

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<P STYLE="page-break-after:always"></P>




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<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>About Compugen</B> <BR>
Compugen&#146;s mission is to be the
world leader in the discovery and licensing of product candidates to the drug and
diagnostic industry. The Company&#146;s powerful discovery engines enable the predictive
discovery of numerous potential therapeutics and diagnostic biomarkers. This capability
results from the Company&#146;s decade-long pioneering efforts in the deeper understanding
of important biological phenomena at the molecular level through the incorporation of
ideas and methods from mathematics, computer science and physics into biology, chemistry
and medicine. To date, Compugen&#146;s product discovery efforts and its initial discovery
engines have focused mainly within the areas of cancer, immune-related and cardiovascular
diseases. The Company&#146;s primary commercialization pathway for its product candidates
is to enter into milestone and revenue sharing out-licensing and joint development
agreements with leading therapeutic and diagnostic companies. Compugen has established an
agricultural biotechnology affiliate &#150; Evogene, and a small-molecule drug discovery
affiliate &#150; Keddem Bioscience. For additional information, please visit
Compugen&#146;s corporate Website at www.cgen.com. </FONT></P>

<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2><I>This press release may contain
&#147;forward-looking statements&#148; within the meaning of the Private Securities
Litigation Reform Act of 1995. These statements include words such as &#147;may&#148;,
&#147;expects&#148;, &#147;anticipates&#148;, &#147;believes&#148;, and
&#147;intends&#148;, and describe opinions about future events. These forward-looking
statements involve known and unknown risks and uncertainties that may cause the actual
results, performance or achievements of Compugen to be materially different from any
future results, performance or achievements expressed or implied by such forward-looking
statements. Some of these risks are: changes in relationships with collaborators; the
impact of competitive products and technological changes; risks relating to the
development of new products; and the ability to implement technological improvements.
These and other factors are identified and more fully explained under the heading
&#147;Risk Factors&#148; in Compugen&#146;s annual reports filed with the Securities and
Exchange Commission.</I> </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Left-TNR" FSL="Workstation" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B><I>Company contact: </I></B><BR>
Naomi Rabbie <BR>
Corporate Communications
Manager <BR>
Compugen Ltd. <BR>
Email: <U>naomir@cgen.com</U> <BR>
Tel: +972-52-598-9894 </FONT></P>

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`
end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
