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<SEC-DOCUMENT>0001178913-09-000227.txt : 20090203
<SEC-HEADER>0001178913-09-000227.hdr.sgml : 20090203
<ACCEPTANCE-DATETIME>20090203071233
ACCESSION NUMBER:		0001178913-09-000227
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20090203
FILED AS OF DATE:		20090203
DATE AS OF CHANGE:		20090203

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		09563010

	BUSINESS ADDRESS:	
		STREET 1:		72 PINCHAS ROSEN ST
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			69512
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		72 PINCHAS ROSEN ST
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			69512
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk96324.htm
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     <!-- Control Number: 96324                                                            -->
     <!-- Rev Number:     1                                                                -->
     <!-- Client Name:    Compugen Ltd                                                     -->
     <!-- Project Name:   6-K                                                              -->
     <!-- Firm Name:      Zadok-Keinan Ltd                                                 -->
     <TITLE>6-K</TITLE>
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<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE="4"><B>FORM 6-K
<BR>SECURITIES AND EXCHANGE COMMISSION</B> </FONT></P>


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<P ALIGN=center><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>Washington,
D.C. 20549</B> </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Sub 2 Left-TNR" FSL="Default" -->
<P ALIGN=center><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>Report
of Foreign Private Issuer</B> </FONT></P>

<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant to rule 13a-16 or 15d-16 of the Securities Exchange Act of 1934
<BR>for the month of February 2009</FONT></P>


<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE="5"><U><B>Compugen Ltd.</B></U> </FONT><BR>
<FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Translation of registrant's name in English)</FONT></P>


<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>72 Pinchas Rosen Street, Tel-Aviv 69512, Israel
</U><BR>(Address of principal executive offices) </FONT></P>


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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Indicate by check mark whether the
registrant files or will file annual reports under cover Form 20-F or Form 40-F. </FONT></P>

<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Form 20-F <FONT size="3" face="Wingdings">x
</font> Form 40-F <FONT size="3" face="Wingdings">o
</font></FONT></P>


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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>On February 3, 2009 Compugen Ltd.
(the &#147;Registrant&#148;) issued a Press Release, filed as Exhibit 1 to this Report on
Form 6-K, which is hereby incorporated by reference herein. </FONT></P>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>SIGNATURE</U> </FONT> </H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant to the requirements of the
Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed
on its behalf by the undersigned, thereunto duly authorized. </FONT></P>



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<TD WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=50%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> Compugen Ltd.<BR>(Registrant)<BR><BR>
<BR>By: /s/ Ms. Dikla Czaczkes Axselbard<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Ms. Dikla Czaczkes Axselbard<BR>Chief Financial Officer<BR>Date: February 3, 2009</FONT></TD>
</TR>
</TABLE>
<BR>

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<FILENAME>exhibit_1.htm
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     <!-- Project:        \\Backup\edgar filing\Compugen Ltd\96324\a96324.eep              -->
     <!-- Control Number: 96324                                                            -->
     <!-- Rev Number:     1                                                                -->
     <!-- Client Name:    Compugen Ltd                                                     -->
     <!-- Project Name:   6-K                                                              -->
     <!-- Firm Name:      Zadok-Keinan Ltd                                                 -->
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<H1 ALIGN=right><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U><B>Exhibit 1</B></U> </FONT> </H1>

<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2><IMG SRC="compugenb.jpg"></font></P>


<!-- MARKER FORMAT-SHEET="Head Left-TNR" FSL="Default" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>For Release </FONT></P>

<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>Compugen Announces Discovery of Biomarker Candidate for
<BR>Diagnosis of Ovarian Cancer and Signing of Collaboration Agreement</B> </FONT></P>

<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B><I>Discovery Highlights Compugen's "Discovery on Demand" Capabilities;
<BR>Agreement Includes Research Collaboration and Worldwide License Option</I></B> </FONT> </P>



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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Tel Aviv, Israel, February 3, 2009
&#150; Compugen Ltd. (NASDAQ: CGEN) disclosed today the discovery and experimental
verification of CGEN-327, a novel molecular biomarker candidate for the diagnosis of
ovarian cancer. CGEN-327 is a previously unknown splice variant of the HE4 (Human
Epididymis Protein 4) gene, which is a known biomarker for ovarian cancer. The company
also announced that it has entered into a research and license option agreement for the
product candidate with a leading diagnostic company. Patent coverage for this discovery is
being pursued by Compugen. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Anat Cohen-Dayag, vice president of
R&amp;D for Compugen stated, &#147;This is an excellent example of Compugen&#146;s unique
&#147;discovery on demand&#148; capabilities. In this case, we were approached by a
leading company developing and commercializing immunoassay panels for rapid diagnosis of
challenging diseases. Their specific interest was to determine whether any unknown splice
variants exist for this known biomarker for ovarian cancer, an objective with a high level
of industry interest and past research activity.&#148; </FONT></P>

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     <P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Dr.
          Cohen-Dayag continued, &#147;In comparison to the traditional and frequently
          used experimentally based discovery methodologies, Compugen&#146;s effort was
          based on computational<I> </I>predictions of the human transcriptome and
          proteome provided by its LEADS platform. Utilizing proprietary algorithms for
          sequence alignment as well as proprietary data sets, gene structure prediction
          and gene products prediction, the probable structure of a previously unknown
          potential splice variant expressed by the HE4 gene was predicted without any wet
          lab experimentation. Based on this probable structure, Compugen predicted the
          complete transcript and protein sequence which was then verified by experimental
          analysis. In these validation experiments, the computationally predicted
          variant, CGEN -327, was successfully shown to both exist in ovary tissues and to
          be differentially expressed at a higher level in ovarian cancer tissues.&#148; </FONT></P>

<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The recently signed collaboration
agreement provides Compugen&#146;s partner with an option to obtain worldwide royalty
bearing commercialization rights for diagnostic products based on this unique and novel
gene product, with Compugen retaining all therapeutic applications. Financial terms were
not disclosed. </FONT></P>


<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>About Ovarian Cancer and
Compugen&#146;s Activities in this Area:</B> <BR>Ovarian cancer is the leading cause
of death from gynecological cancer with more than 15,000 deaths and more than 21,000 new
cases in 2008 in the United States alone. Often referred to as &#147;the silent
killer&#148;, it is known to cause non-specific symptoms leading, in a large majority of
cases, to delayed diagnosis. Therefore, a good diagnostic test is widely sought. </FONT> </P>

<p align=center>
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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>In view of the importance of this
unmet diagnostic need, during the past few years, Compugen selected and began evaluating a
number of novel molecules, that in addition to CGEN-327, were predicted by the discovery
platforms to have medical and commercial opportunities in the diagnosis or treatment of
ovarian cancer. These activities have resulted in the granting, earlier this month, of a
patent to Compugen covering several of these other novel molecules. Although Compugen did
not announce the granting of this patent, it was publicly disclosed by the US Patent and
Trademark office and reported in a number of publications. </FONT></P>


<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>About Compugen</B><BR>Compugen is a leading drug and
diagnostic product candidate discovery company. Unlike traditional high throughput trial
and error experimental based discovery, Compugen&#146;s discovery efforts are based on
<I>in-silico</I> (by computer) prediction and selection utilizing a growing number of
field focused proprietary discovery platforms accurately modeling biological processes at
the molecular level. The resulting product candidates are then validated through <I>in
vitro</I> and <I>in vivo</I> experimental studies and out-licensed for further development
and commercialization under various forms of revenue sharing agreements. Compugen&#146;s
current collaborations include Biosite, Medarex, Inc., Merck &amp; Co., Inc.,
Ortho-Clinical Diagnostics (a Johnson &amp; Johnson company), Roche, Siemens Healthcare
Diagnostics, Inc., and Teva Pharmaceutical Industries. In 2002, Compugen established an
affiliate, Evogene Ltd. <U>www.evogene.com</U> (TASE: EVGN.TA), to utilize certain of the
Company&#146;s <I>in-silico</I> predictive discovery capabilities in agricultural
biotechnology. For additional information, please visit Compugen&#146;s corporate Web site
at <U>www.cgen.com</U>. </FONT> </P>

<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>This press release may contain
&#147;forward-looking statements&#148; within the meaning of the Private Securities
Litigation Reform Act of 1995. These statements include words such as &#147;may&#148;,
&#147;expects&#148;, &#147;anticipates&#148;, &#147;believes&#148;, and
&#147;intends&#148;, and describe opinions about future events. These forward-looking
statements involve known and unknown risks and uncertainties that may cause the actual
results, performance or achievements of Compugen to be materially different from any
future results, performance or achievements expressed or implied by such forward-looking
statements. Some of these risks are: changes in relationships with collaborators; the
impact of competitive products and technological changes; risks relating to the
development of new products; and the ability to implement technological improvements.
These and other factors are identified and more fully explained under the heading
&#147;Risk Factors&#148; in Compugen&#146;s annual reports filed with the Securities and
Exchange Commission. </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Left-TNR" FSL="Default" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B><I>Company contact:</I></B> </FONT> </P>

<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Marjie Hadad<BR>
Global Media Liaison
<BR>Compugen Ltd.
<BR>Email: marjie@cgen.com
<BR>Tel: +972-54-536-5220</font></P>

<p align=center>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
