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<SEC-DOCUMENT>0001178913-09-000644.txt : 20090324
<SEC-HEADER>0001178913-09-000644.hdr.sgml : 20090324
<ACCEPTANCE-DATETIME>20090324070658
ACCESSION NUMBER:		0001178913-09-000644
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20090324
FILED AS OF DATE:		20090324
DATE AS OF CHANGE:		20090324

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		09700117

	BUSINESS ADDRESS:	
		STREET 1:		72 PINCHAS ROSEN ST
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			69512
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		72 PINCHAS ROSEN ST
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			69512
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk96554.htm
<TEXT>

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     <!-- Control Number: 96554                                                            -->
     <!-- Rev Number:     1                                                                -->
     <!-- Client Name:    Compugen Ltd                                                     -->
     <!-- Project Name:   6-K                                                              -->
     <!-- Firm Name:      Zadok-Keinan Ltd                                                 -->
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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=4>FORM 6-K </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=4>SECURITIES AND
EXCHANGE COMMISSION </FONT></H1>

<!-- MARKER FORMAT-SHEET="Head Major Center Bold 1-TNR" FSL="Workstation" -->
<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Washington, D.C. 20549 </FONT></H1>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Report of Foreign
Private Issuer </FONT></H1>


<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuantto rule 13a-16 or 15d-16 of the Securities Exchange Act of 1934 <BR> for the month of March 2009</FONT></P>

<!-- MARKER FORMAT-SHEET="Head Center Underline-TNR" FSL="Workstation" -->
<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="5"><B><U>Compugen Ltd.</U></B> </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE="2">(Translation of registrant&#146;s name in English) </FONT> </P>




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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2><U>72 Pinchas Rosen
Street, Tel-Aviv 69512, Israel </U></FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Address of principal executive offices) </FONT></P>


<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F. </font></P>

<P align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Form 20-F   <FONT size="3" face="Wingdings">x
</font>   Form 40-F <FONT size="3" face="Wingdings">o
</font> </FONT></P>





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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>On March 24, 2009 Compugen Ltd. (the
&#147;Registrant&#148;) issued a Press Release, filed as Exhibit 1 to this Report on Form
6-K, which is hereby incorporated by reference herein. </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Major Center Bold-TNR" FSL="Workstation" -->
<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B><U>SIGNATURE</U></B> </FONT> </H1>




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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant to the requirements of the
Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed
on its behalf by the undersigned, thereunto duly authorized. </FONT></P>


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<TD WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=50%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Compugen Ltd.<BR>(Registrant)<BR>
<BR>By: /s/ Ms. Dikla Czaczkes Axselbard<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Ms. Dikla Czaczkes Axselbard<BR>Title: Chief Financial Officer<BR>Date: March 24, 2009</FONT></TD>
</TR>
</TABLE>
<BR>


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<TYPE>EX-99
<SEQUENCE>2
<FILENAME>exhibit_1.htm
<TEXT>



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     <!-- Project:        F:\EDGAR Filing\Compugen Ltd\96554\a96554.eep                    -->
     <!-- Control Number: 96554                                                            -->
     <!-- Rev Number:     1                                                                -->
     <!-- Client Name:    Compugen Ltd                                                     -->
     <!-- Project Name:   6-K                                                              -->
     <!-- Firm Name:      Zadok-Keinan Ltd                                                 -->
     <TITLE>6-K</TITLE>
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<H1 ALIGN="Right"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B><U>Exhibit 1</U></B> </FONT> </H1>



<IMG SRC="compugenb.jpg">



<!-- MARKER FORMAT-SHEET="Head Left-TNR" FSL="Workstation" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>For Release </FONT></P>




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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Teva to Utilize
Compugen-Discovered Biomarkers for<BR>Pre-Clinical
Detection of Drug-induced Kidney Toxicity </FONT></P>


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<P ALIGN="Center"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Compugen to commercialize biomarkers during second half of 2009 </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Tel-Aviv, Israel, March 24, 2009<B>
&#150; </B> Compugen Ltd. (NASDAQ: CGEN) announced today that Teva Pharmaceutical
Industries has exercised its option to utilize in its research activities a novel
combination of biomarkers, discovered by Compugen, for early detection of drug-induced
nephrotoxicity. This biomarker combination was discovered under the umbrella of
collaboration between Compugen and Teva. Compugen also announced today its plans to
commercially introduce the markers through licensing arrangements during the second half
of this year. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Under the terms of the collaboration
with Teva, initiated in 2007, Compugen conducted a discovery process utilizing its
proprietary computational tools, discovery engines and nucleic acid testing platforms as
well as data derived from biological samples collected by Teva in a preclinical study
designed specifically for this project. The business terms for the collaboration provided
Teva with the royalty-free right to use any discovered markers for internal research and
development activities; Compugen retained the commercialization rights for licensing such
markers to other companies, as well as rights for internal use. </FONT></P>

<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Validation results demonstrate that
the biomarker signature may enable a much earlier prediction of drug-induced kidney
toxicity during pre-clinical trials in rats in comparison to traditional diagnostic
methods such as histopathology or clinical chemistry. In addition, the biomarker
combination successfully predicted the relative levels of toxicity of the compounds that
were tested. </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Major Left Bold-TNR" FSL="Workstation" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>About Drug-induced
Nephrotoxicity</B> </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Current tools for diagnosis of kidney
function involve blood tests, such as blood urea nitrogen and serum creatinine levels,
which show significant results only after substantial kidney injury has occurred. The
pharmaceutical industry spends considerable amounts of money, time and effort trying to
detect toxic drug effects as early as possible in order to avoid the incorporation of such
drug candidates into more expensive drug development stages. Since the kidney is one of
the primary sites of drugs toxicity, early detection of nephrotocxicity in the preclinical
stage of drug development is an important unmet need. </FONT> </P>

<!-- MARKER FORMAT-SHEET="Head Major Left Bold-TNR" FSL="Workstation" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>About Compugen&#146;s
Nucleic Acid Testing (NAT) Discovery Platform</B> </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE="2">This Platform relies on
Compugen&#146;s LEADS and MED infrastructure platforms and additional public and
proprietary data sources. Various algorithms and statistical and machine learning tools
are used to discover novel RNA transcripts that can serve as diagnostic biomarkers. The
platform has been designed to predict and discover single and multiple combination
biomarkers; the platform can also be used to discover such biomarkers for any organ
toxicity and/or various disease biomarkers. </FONT> </P>


<p align=center>
<font size=2></font></p>
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<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>About Compugen</B> </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Compugen is a leading drug and
diagnostic product candidate discovery company. Unlike traditional high throughput trial
and error experimental based discovery, Compugen&#146;s discovery efforts are based on
<I>in-silico</I> (by computer) prediction and selection utilizing a growing number of
field focused proprietary discovery platforms accurately modeling biological processes at
the molecular level. The resulting product candidates are then validated through <I>in
vitro</I> and <I>in vivo</I> experimental studies and out-licensed for further development
and commercialization under various forms of revenue sharing agreements. Compugen&#146;s
current collaborations include Biosite, Medarex, Inc., Merck &amp; Co., Inc., Merck
Serono, Ortho-Clinical Diagnostics (a Johnson &amp; Johnson company), Roche, Siemens
Healthcare Diagnostics, Inc., and Teva Pharmaceutical Industries. In 2002, Compugen
established an affiliate, Evogene Ltd. <U>www.evogene.com</U> (TASE: EVGN.TA), to utilize
certain of the Company&#146;s <I>in-silico</I> predictive discovery capabilities in
agricultural biotechnology. For additional information about Compugen, please visit the
Company&#146;s corporate Web site at <U>www.cgen.com</U>. </FONT> </P>

<!-- MARKER FORMAT-SHEET="Para Flush Lv 0-TNR" FSL="Workstation" -->
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>This press release may contain
&#147;forward-looking statements&#148; within the meaning of the Private Securities
Litigation Reform Act of 1995. These statements include words such as &#147;may,&#148;
&#147;expects,&#148; &#147;anticipates,&#148; &#147;believes,&#148; and
&#147;intends,&#148; and describe opinions about future events. These forward-looking
statements involve known and unknown risks and uncertainties that may cause the actual
results, performance or achievements of Compugen to be materially different from any
future results, performance or achievements expressed or implied by such forward-looking
statements. Some of these risks are: changes in relationships with collaborators; the
impact of competitive products and technological changes; risks relating to the
development of new products; and the ability to implement technological improvements.
These and other factors are identified and more fully explained under the heading
&#147;Risk Factors&#148; in Compugen&#146;s annual reports filed with the Securities and
Exchange Commission. </FONT></P>

<!-- MARKER FORMAT-SHEET="Head Major Left Bold-TNR" FSL="Workstation" -->
<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>Company contact:</B> </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Marjie Hadad<BR>Global
Media Liaison<BR>Compugen Ltd.<BR>Email: marjie@cgen.com<BR>Tel:
+972-54-536-5220 </FONT> </P>

<p align=center>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
