<SEC-DOCUMENT>0001178913-20-000808.txt : 20200313
<SEC-HEADER>0001178913-20-000808.hdr.sgml : 20200313
<ACCEPTANCE-DATETIME>20200313161017
ACCESSION NUMBER:		0001178913-20-000808
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		5
CONFORMED PERIOD OF REPORT:	20200313
FILED AS OF DATE:		20200313
DATE AS OF CHANGE:		20200313

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		20712746

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk2024160.htm
<DESCRIPTION>6-K
<TEXT>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">Form 6-K</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">For the month of March 2020</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">Commission File Number 000-30902</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold;">COMPUGEN LTD.</div>
    <div style="text-align: center; line-height: 1.25;">(Translation of registrant&#8217;s name into English)</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z4db90e26f3b94803847171d0be165de7">

        <tr>
          <td style="width: 100%; vertical-align: middle;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">26&#160;Harokmim Street</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Holon 5885849, Israel</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">(Address of Principal Executive Offices)&#160;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:</div>
    <div style="line-height: 1.25;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Form 20-F &#9746;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Form 40-F &#9744;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): &#160;&#160; &#9744;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): &#160;&#160; &#9744;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="background-color: #FFFFFF; line-height: 1.25;">
      <div style="line-height: 1.25;"><font style="background-color: #FFFFFF;">On March 11, 2020, we entered into an underwriting agreement (the &#8220;Underwriting Agreement&#8221;) with SVB Leerink LLC and Stifel, </font>Nicolaus &amp; Company, Incorporated<font style="background-color: #FFFFFF;">, as representatives of the several underwriters named therein (collectively, the &#8220;Underwriters&#8221;), relating to the issuance and sale in a public offering of 8,333,334 of our ordinary shares,</font>&#160;<font style="background-color: #FFFFFF;">nominal (par) value NIS 0.01 per share. The price to the public in the offering is $9.00 per share and the Underwriters have agreed to purchase the shares from us pursuant to the Underwriting Agreement at a
          price of $8.46 per share. The net proceeds to us from the offering are expected to be approximately $70.1 million, after deducting the underwriting discounts and commissions and estimated offering expenses payable by us. The closing of the
          offering is expected to occur on March 16, 2020, subject to customary closing conditions. In addition, we granted the Underwriters a 30-day option to purchase up to 1,250,000 additional shares of our common stock at the public offering price,
          less the underwriting discounts and commissions.</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"><font style="background-color: #FFFFFF;">The Underwriting Agreement contains customary representations, warranties and agreements by us, customary conditions to closing, indemnification obligations of us and the
          Underwriters, including for liabilities under the Securities Act of 1933, as amended, other obligations of the parties and termination provisions. The representations, warranties and covenants contained in the Underwriting Agreement were made
          only for purposes of such agreement and as of specific dates, were solely for the benefit of the parties to such agreement, and may be subject to limitations agreed upon by such parties.</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"><font style="background-color: #FFFFFF;">The offering is being made pursuant to our effective registration statement on Form F-3 and accompanying prospectus (Registration Statement No. 333-233001), previously filed
          with the Securities and Exchange Commission (&#8220;SEC&#8221;), and a prospectus supplement thereunder. A copy of the Underwriting Agreement is filed as Exhibit 1.1 to this report, and the foregoing description of the terms of the Underwriting Agreement
          does not purport to be complete and is qualified in its entirety by reference to such exhibit. A copy of the opinion of Shibolet &amp; Co. relating to the legality of the issuance and sale of the shares in the offering is attached as Exhibit 5.1.</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Forward-Looking Statement</div>
    <div style="line-height: 1.25;">This report contains &#8220;forward-looking statements&#8221; within the meaning of the Securities Act of 1933 and the Securities Exchange Act of 1934, as amended, and the safe-harbor provisions of the Private Securities Litigation
      Reform Act of 1995. Such forward-looking statements are based on the current beliefs, expectations and assumptions of Compugen. Forward-looking statements can be identified by the use of terminology such as
      &#8220;will,&#8221;&#160;&#8220;may,&#8221;&#160;&#8220;expects,&#8221;&#160;&#8220;anticipates,&#8221;&#160;&#8220;believes,&#8221;&#160;&#8220;potential,&#8221;&#160;&#8220;plan,&#8221;&#160;&#8220;goal,&#8221;&#160;&#8220;estimate,&#8221;&#160;&#8220;likely,&#8221;&#160;&#8220;should,&#8221;&#160;&#8220;confident,&#8221; and &#8220;intends,&#8221; and similar expressions that are intended to identify forward-looking statements, including the completion
      and timing of the offering and the underwriters&#8217; option to purchase additional shares, although not all forward-looking statements contain these identifying words. These forward-looking statements involve known and unknown risks and uncertainties
      that may cause the actual results, performance or achievements of Compugen to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Among these risks: Clinical
      development involves a lengthy and expensive process, with an uncertain outcome and Compugen may encounter substantial delays or even an inability to begin clinical trials for any specific product, or may not be able to conduct or complete its trials
      on the timelines it expects; Compugen relies, and expects to continue to rely, on third parties to conduct its clinical trials and if these third parties do not successfully carry out their contractual duties, comply with regulatory requirements or
      meet expected deadlines (including as a result of the effect of the Coronavirus), Compugen may experience significant delays in the conduct of its clinical trials; Compugen&#8217;s ability to present data derived from collaborations with its partners is
      dependent in some cases on the agreement of our partners to present such data, and in any event is dependent on our acceptance to present data in relevant conferences; Compugen&#8217;s approach to the discovery of therapeutic products is based on its
      proprietary computational target discovery infrastructure, which is unproven clinically; Compugen does not know whether it will be able to discover and develop additional potential product candidates or products of commercial value; Compugen&#8217;s
      business model is substantially dependent on entering into collaboration agreements with third parties; and Compugen may not be successful in generating adequate revenues or commercializing aspects of its business model. These risks and other risks
      are more fully described in the &#8220;Risk Factors&#8221; section of Compugen&#8217;s most recent Annual Report on Form 20-F filed with the Securities and Exchange Commission (SEC) as well as other documents that may be subsequently filed by Compugen from time to
      time with the SEC. In addition, any forward-looking statements represent Compugen&#8217;s views only as of the date of this release and should not be relied upon as representing its views as of any subsequent date. Compugen does not assume any obligation
      to update any forward-looking statements unless required by law.</div>
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    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Exhibits</div>
    <br>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div>
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                  <div style="line-height: 1.25; font-weight: bold;">Exhibit</div>
                  <div style="line-height: 1.25;"><font style="font-weight: bold;"><u>Number</u></font>&#160; <br>
                  </div>
                </td>
                <td style="width: auto; vertical-align: top;">
                  <div><font style="font-weight: bold;"><u> <br>
                      </u></font></div>
                  <div><font style="font-weight: bold;"><u>Description of Exhibit</u></font></div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <font style="font-weight: bold;"><u> </u></font></div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z822d705ab5314c8db13114598daf36c4">

            <tr>
              <td style="width: 72pt; vertical-align: top; align: right;"><a href="exhibit_1-1.htm">1.1</a></td>
              <td style="width: auto; vertical-align: top;">
                <div><a href="exhibit_1-1.htm">Underwriting Agreement, dated March 11, 2020, by and among Compugen Ltd. and SVB Leerink LLC and Stifel, Nicolaus
                    &amp; Company, Incorporated, as representatives of the several underwriters named therein.</a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z01bab07da462442ca21eb39b7e18e8cd">

            <tr>
              <td style="width: 72pt; vertical-align: top; align: right;"><a href="exhibit_5-1.htm">5.1</a></td>
              <td style="width: auto; vertical-align: top;">
                <div><a href="exhibit_5-1.htm">Opinion of Shibolet &amp; Co.</a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zeeed1f07ccc34778a1b1777ac43fe43f">

            <tr>
              <td style="width: 72pt; vertical-align: top; align: right;"><a href="exhibit_5-1.htm">23.1</a></td>
              <td style="width: auto; vertical-align: top;">
                <div><a href="exhibit_5-1.htm">Consent of Shibolet &amp; Co. (included in Exhibit 5.1).</a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signatures</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z854c133799dc4e69ae114dac1a790c4c">

        <tr>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td colspan="3" style="vertical-align: bottom;">
            <div style="line-height: 1.25; font-weight: bold;">COMPUGEN LTD.</div>
          </td>
        </tr>
        <tr>
          <td colspan="4" style="vertical-align: middle;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Date: March 13, 2020</div>
          </td>
          <td style="width: 4%; vertical-align: bottom;">
            <div style="line-height: 1.25;">By:&#160;</div>
          </td>
          <td style="width: 38.3%; vertical-align: bottom; border-bottom: 2px solid black;">
            <div style="line-height: 1.25;">/s/ Eran Ben Dor&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
          </td>
          <td style="width: 12%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 4%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 38.3%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Eran Ben Dor</div>
            <div style="line-height: 1.25;">General Counsel</div>
          </td>
          <td style="width: 12%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">&#160;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>2
<FILENAME>exhibit_1-1.htm
<DESCRIPTION>EXHIBIT 1.1
<TEXT>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
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      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
    <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"> <u><font style="font-weight: bold;">Exhibit 1.1</font></u><br>
    </div>
    <div style="text-align: center; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25;">Compugen Ltd.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;">(a company organized under the laws of the State of Israel)</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;">8,333,334 Ordinary Shares</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNDERWRITING AGREEMENT</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: right; line-height: 1.25;">March 11, 2020</div>
    <div style="line-height: 1.25;">SVB Leerink LLC</div>
    <div style="line-height: 1.25;">Stifel, Nicolaus &amp; Company, Incorporated</div>
    <div style="line-height: 1.25;">as Representatives of the several Underwriters</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">c/o SVB Leerink LLC</div>
    <div style="line-height: 1.25;">One Federal Street, 37th Floor</div>
    <div style="line-height: 1.25;">Boston, MA 02110</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">c/o Stifel, Nicolaus &amp; Company, Incorporated</div>
    <div style="line-height: 1.25;">787 Seventh Avenue, 11th Floor</div>
    <div style="line-height: 1.25;">New York, New York 10019</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Ladies and Gentlemen:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Compugen Ltd., a corporation organized under the laws of the State of Israel (the &#8220;<u>Company</u>&#8221;), confirms its agreement with SVB Leerink LLC (&#8220;<u>SVB Leerink</u>&#8221;), Stifel,
      Nicolaus &amp; Company, Incorporated (&#8220;<u>Stifel</u>&#8221;) and each of the other Underwriters named in <u>Schedule&#160;A</u> hereto (collectively, the &#8220;<u>Underwriters</u>,&#8221; which term shall also include any underwriter substituted as hereinafter provided
      in Section&#160;10 hereof), for which SVB Leerink and Stifel are acting as representatives (in such capacity, the &#8220;<u>Representatives</u>&#8221;), with respect to (i) the sale by the Company and the purchase by the Underwriters, acting severally and not
      jointly, of the respective numbers of ordinary shares, nominal (par) value NIS 0.01 per share, of the Company (&#8220;<u>Ordinary Shares</u>&#8221;) set forth in <u>Schedule&#160;A</u> hereto and (ii) the grant by the Company to the Underwriters, acting severally
      and not jointly, of the option described in Section&#160;2(b) hereof to purchase all or any part of 1,250,000 additional Ordinary Shares.&#160; The aforesaid 8,333,334 Ordinary Shares (the &#8220;<u>Initial Securities</u>&#8221;) to be purchased by the Underwriters and
      all or any part of the 1,250,000 Ordinary Shares subject to the option described in Section 2(b) hereof (the &#8220;<u>Option Securities</u>&#8221;) are herein called, collectively, the &#8220;<u>Securities</u>.&#8221;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company understands that the Underwriters propose to make a public offering of the Securities as soon as the Representatives deem advisable after this Underwriting Agreement
      (this &#8220;<u>Agreement</u>&#8221;) has been executed and delivered.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company has filed with the Securities and Exchange Commission (the &#8220;<u>Commission</u>&#8221;) a shelf registration statement on Form&#160;F&#8209;3 (No. 333-233001), covering the public
      offering and sale of certain securities, including the Securities, under the Securities Act of 1933, as amended (the &#8220;<u>1933 Act</u>&#8221;) and the rules and regulations of the Commission promulgated thereunder (the &#8220;<u>1933 Act Regulations</u>&#8221;), which
      shelf registration statement was declared effective on August 12, 2019.&#160; Such registration statement, as of any time, means such registration statement as amended by any post-effective amendments thereto to such time, including the exhibits and any
      schedules thereto at such time, the documents incorporated or deemed to be incorporated by reference therein at such time pursuant to Item 6 of Form F-3 under the 1933 Act and the documents otherwise deemed to be a part thereof as of such time
      pursuant to Rule 430B under the 1933 Act Regulations (&#8220;Rule 430B&#8221;), is referred to herein as the &#8220;Registration Statement;&#8221; provided, however, that the &#8220;Registration Statement&#8221; without reference to a time means such registration statement as amended
      by any post-effective amendments thereto as of the time of the first contract of sale for the Securities, which time shall be considered the &#8220;new effective date&#8221; of such registration statement with respect to the Securities within the meaning of
      paragraph (f)(2) of Rule 430B, including the exhibits and schedules thereto as of such time, the documents incorporated or deemed incorporated by reference therein at such time pursuant to Item 6 of Form F-3 under the 1933 Act and the documents
      otherwise deemed to be a part thereof as of such time pursuant to the Rule 430B.&#160; Any registration statement filed pursuant to Rule 462(b) of the 1933 Act Regulations is herein called the &#8220;<u>Rule 462(b) Registration Statement</u>&#8221; and, after such
      filing, the term &#8220;Registration Statement&#8221; shall include the Rule 462(b) Registration Statement.&#160; Each preliminary prospectus used in connection with the offering of the Securities, including the documents incorporated or deemed to be incorporated by
      reference therein pursuant to Item 6 of Form F-3 under the 1933 Act, are collectively referred to herein as a &#8220;preliminary prospectus.&#8221;&#160; After execution and delivery of this Agreement, the Company will prepare and file a final prospectus relating to
      the Securities in accordance with the provisions of Rule 424(b) under the 1933 Act Regulations (&#8220;Rule 424(b)&#8221;).&#160; The final prospectus, in the form first furnished or made available to the Underwriters for use in connection with the offering of the
      Securities, including the documents incorporated or deemed to be incorporated by reference therein pursuant to Item 6 of Form F-3 under the 1933 Act, are collectively referred to herein as the &#8220;Prospectus.&#8221;&#160; For purposes of this Agreement, all
      references to the Registration Statement, any preliminary prospectus, the Prospectus or any amendment or supplement to any of the foregoing shall be deemed to include the copy filed with the Commission pursuant to its Electronic Data Gathering,
      Analysis and Retrieval system (or any successor system)(&#8220;EDGAR&#8221;).</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">As used in this Agreement:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;Applicable Time&#8221; means 6:45 P.M., New York City time, on March 11, 2020 or such other time as agreed by the Company and the Representatives.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;General Disclosure Package&#8221; means any Issuer General Use Free Writing Prospectuses issued at or prior to the Applicable Time, the most recent preliminary
      prospectus (including any documents incorporated therein by reference) that is distributed to investors prior to the Applicable Time and the information included on <u>Schedule&#160;B&#8209;1</u> hereto, all considered together.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;Issuer Free Writing Prospectus&#8221; means any &#8220;issuer free writing prospectus,&#8221; as defined in Rule 433 of the 1933 Act Regulations (&#8220;<u>Rule 433</u>&#8221;), including
      without limitation any &#8220;free writing prospectus&#8221; (as defined in Rule 405 of the 1933 Act Regulations (&#8220;<u>Rule 405</u>&#8221;)) relating to the Securities that is (i) required to be filed with the Commission by the Company, (ii) a &#8220;road show for an
      offering that is a written communication&#8221; within the meaning of Rule 433(d)(8)(i), whether or not required to be filed with the Commission, or (iii) exempt from filing with the Commission pursuant to Rule 433(d)(5)(i) because it contains a
      description of the Securities or of the offering that does not reflect the final terms, in each case in the form filed or required to be filed with the Commission or, if not required to be filed, in the form retained in the Company&#8217;s records pursuant
      to Rule 433(g).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;Issuer General Use Free Writing Prospectus&#8221; means any Issuer Free Writing Prospectus that is intended for general distribution to prospective investors (other
      than a &#8220;<font style="font-style: italic;">bona fide</font> electronic road show,&#8221; as defined in Rule 433 (a &#8220;<u>Bona Fide Electronic Road Show</u>&#8221;)), as evidenced by its being specified in <u>Schedule&#160;B&#8209;2</u> hereto.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">2</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;Issuer Limited Use Free Writing Prospectus&#8221; means any Issuer Free Writing Prospectus that is not an Issuer General Use Free Writing Prospectus.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;Testing-the-Waters Communication&#8221; means any oral or written communication with potential investors undertaken in reliance on Section 5(d) of the 1933 Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;Written Testing-the-Waters Communication&#8221; means any Testing-the-Waters Communication that is a written communication within the meaning of Rule 405 under the
      1933 Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All references in this Agreement to financial statements and schedules and other information which is &#8220;contained,&#8221; &#8220;included&#8221; or &#8220;stated&#8221; (or other references of like import) in
      the Registration Statement, any preliminary prospectus or the Prospectus shall be deemed to include all such financial statements and schedules and other information incorporated or deemed incorporated by reference in the Registration Statement, any
      preliminary prospectus or the Prospectus, as the case may be, prior to the execution and delivery of this Agreement; and all references in this Agreement to amendments or supplements to the Registration Statement, any preliminary prospectus or the
      Prospectus shall be deemed to include the filing of any document under the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder (collectively, the &#8220;1934 Act&#8221;), incorporated or deemed to be incorporated by
      reference in the Registration Statement, such preliminary prospectus or the Prospectus, as the case may be, at or after the execution and delivery of this Agreement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 1.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Representations and Warranties</u>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Representations and Warranties by the Company</font>.&#160; The Company represents and warrants to each Underwriter as of the date hereof,
      the Applicable Time, the Closing Time (as defined below) and any Date of Delivery (as defined below), and agrees with each Underwriter, as follows:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Registration Statement</u><u> and Prospectuses</u>.&#160; The Company meets the requirements for use of Form F-3 under the 1933 Act.&#160; Each of the
      Registration Statement and any amendment thereto has become effective under the 1933 Act.&#160; No stop order suspending the effectiveness of the Registration Statement or any post-effective amendment thereto has been issued by the Commission under the
      1933 Act, no order preventing or suspending the use of any preliminary prospectus or the Prospectus has been issued by the Commission and no proceedings for any of those purposes have been instituted by the Commission or are pending or, to the
      Company&#8217;s knowledge, contemplated by the Commission.&#160; The Company has complied with each request (if any) from the Commission for additional information.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">Each of the Registration Statement and any post-effective amendment thereto, at the time of its effectiveness and at each deemed effective date with respect to
      the Underwriters pursuant to Rule 430B(f)(2) under the 1933 Act Regulations, complied in all material respects with the requirements of the 1933 Act and the 1933 Act Regulations.&#160; Each preliminary prospectus, the Prospectus and any amendment or
      supplement thereto, at the time each was filed with the Commission, complied in all material respects with the requirements of the 1933 Act and the 1933 Act Regulations.&#160; Each preliminary prospectus delivered to the Underwriters for use in connection
      with the offering and the Prospectus was or will be identical to the electronically transmitted copies thereof filed with the Commission pursuant to EDGAR, except to the extent permitted by Regulation S-T.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">The documents incorporated or deemed to be incorporated by reference in the Registration Statement and the Prospectus, when they became effective or at the time
      they were or hereafter are filed with the Commission, complied and will comply in all material respects with the requirements of the 1934 Act and the rules and regulations of the Commission under the 1934 Act (the &#8220;1934 Act Regulations&#8221;).</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">3</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">The Registration Statement, any preliminary prospectus and the Prospectus, and the filing of the Registration Statement, any preliminary prospectus and the
      Prospectus with the Commission have been duly authorized by and on behalf of the Company, and the Registration Statement has been duly executed pursuant to such authorization.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Accurate Disclosure</u>.&#160; Neither the Registration Statement nor any amendment thereto, at its effective time, at the Closing Time or at any
      Date of Delivery, contained, contains or will contain an untrue statement of a material fact or omitted, omits or will omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading.&#160; As of the
      Applicable Time, none of (A) the General Disclosure Package, (B) any individual Issuer Limited Use Free Writing Prospectus, when considered together with the General Disclosure Package, nor (C) any individual Written Testing-the-Waters Communication,
      when considered together with the General Disclosure Package, included, includes or will include an untrue statement of a material fact or omitted, omits or will omit to state a material fact necessary in order to make the statements therein, in the
      light of the circumstances under which they were made, not misleading.&#160; Neither the Prospectus nor any amendment or supplement thereto (including any prospectus wrapper), as of its issue date, at the time of any filing with the Commission pursuant to
      Rule 424(b), at the Closing Time or at any Date of Delivery, included, includes or will include an untrue statement of a material fact or omitted, omits or will omit to state a material fact necessary in order to make the statements therein, in the
      light of the circumstances under which they were made, not misleading.&#160; The documents incorporated or deemed to be incorporated by reference in the Registration Statement, the General Disclosure Package and the Prospectus, at the time the
      Registration Statement became effective or when such documents incorporated by reference were filed with the Commission, as the case may be, when read together with the other information in the Registration Statement, the General Disclosure Package
      or the Prospectus, as the case may be, did not and will not include an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">The representations and warranties in this subsection shall not apply to statements in or omissions from the Registration Statement (or any amendment thereto),
      the General Disclosure Package or the Prospectus (or any amendment or supplement thereto, including any prospectus wrapper) made in reliance upon and in conformity with written information furnished to the Company by any Underwriter through the
      Representatives expressly for use therein.&#160; For purposes of this Agreement, the only information so furnished shall be the information in the first paragraph under the heading &#8220;Underwriting &#8211; Discounts and Commissions,&#8221; the information in the second,
      third and fourth paragraphs under the heading &#8220;Underwriting &#8211; Price Stabilization, Short Positions and Penalty Bids&#8221; and the information under the heading &#8220;Underwriting &#8211; Electronic Distribution&#8221; in each case contained in the Prospectus
      (collectively, the &#8220;<u>Underwriter Information</u>&#8221;).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Issuer Free Writing Prospectuses</u>.&#160; No Issuer Free Writing Prospectus conflicts or will conflict with the information contained in the
      Registration Statement or the Prospectus, including any document incorporated by reference therein, and any preliminary or other prospectus deemed to be a part thereof that has not been superseded or modified.&#160; No filing of any &#8220;road show&#8221; (as
      defined in Rule 433(h)) is required in connection with the offering of the Securities.&#160; Any Issuer Free Writing Prospectus that the Company is required to file pursuant to Rule 433(d) under the Securities Act has been, or will be, filed with the
      Commission in accordance with the requirements of the 1933 Act and the 1933 Act Regulations.&#160; Each Issuer Free Writing Prospectus that the Company has filed, or is required to file, pursuant to Rule 433(d) under the 1933 Act or that was prepared by
      or behalf of or used or referred to by the Company complies or will comply in all material respects with the requirements of the 1933 Act and the 1933 Act Regulations.&#160; Except for the Issuer Free Writing Prospectuses, if any, identified in <u>Schedule
        B-2</u> hereto, and electronic road shows, if any, each furnished to the Representatives before first use, the Company has not prepared, used or referred to, and will not, without the prior consent of the Representatives, prepare, use or refer to,
      any issuer free writing prospectus.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">4</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Testing-the-Waters Materials</u>.&#160; The Company (A) has not engaged in any Testing-the-Waters Communication other than Testing-the-Waters
      Communications with the consent of the Representatives with entities that are qualified institutional buyers within the meaning of Rule 144A under the 1933 Act or institutions that are accredited investors within the meaning of Rule 501 under the
      1933 Act and (B) has not authorized anyone other than the Representatives to engage in Testing-the-Waters Communications.&#160; The Company reconfirms that the Representatives have been authorized to act on its behalf in undertaking Testing-the-Waters
      Communications.&#160; The Company has not distributed any Written Testing-the-Waters Communications other than those listed on <u>Schedule B-3</u> hereto.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Company Not Ineligible Issuer</u>.&#160; At the time of filing the Registration Statement and any post-effective amendment thereto, at the earliest
      time thereafter that the Company or another offering participant made a <font style="font-style: italic;">bona fide</font> offer (within the meaning of Rule 164(h)(2) of the 1933 Act Regulations) of the Securities and at the date hereof, the Company
      was not and is not an &#8220;ineligible issuer,&#8221; as defined in Rule 405, without taking account of any determination by the Commission pursuant to Rule 405 that it is not necessary that the Company be considered an ineligible issuer.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(vi)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; <u>Foreign Private Issuer</u>.&#160; The Company is a &#8220;foreign private issuer,&#8221; as such term is defined in Rule 405 of the 1933 Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(vii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Independent Accountants</u>.&#160; The accountants who certified the financial statements and supporting schedules included in the Registration
      Statement, the General Disclosure Package and the Prospectus are independent public accountants as required by the 1933 Act, the 1933 Act Regulations, the 1934 Act, the 1934 Act Regulations and the Public Company Accounting Oversight Board (United
      States).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(viii)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Financial Statements; Non-GAAP Financial Measures</u>.&#160; The financial statements included or incorporated by reference in the Registration
      Statement, the General Disclosure Package and the Prospectus, together with the related schedules and notes, comply as to form in all material respects with Regulation S-X under the 1933 Act and present fairly, in all material respects, the financial
      position of the Company and its consolidated Subsidiary (as defined below) at the dates indicated and the statement of operations, shareholders&#8217; equity and cash flows of the Company and its consolidated Subsidiary for the periods specified; said
      financial statements have been prepared in conformity with U.S. generally accepted accounting principles (&#8220;<u>GAAP</u>&#8221;) applied on a consistent basis throughout the periods involved.&#160; The supporting schedules, if any, present fairly, in all material
      respects, in accordance with GAAP, the information required to be stated therein.&#160; The selected financial data and the summary financial information included in the Registration Statement, the General Disclosure Package and the Prospectus present
      fairly, in all material respects, the information shown therein and have been compiled on a basis consistent with that of the audited financial statements included therein.&#160; Except as included therein, no historical or pro forma financial statements
      or supporting schedules are required to be included or incorporated by reference in the Registration Statement, the General Disclosure Package or the Prospectus under the 1933 Act or the 1933 Act Regulations.&#160; All disclosures contained in the
      Registration Statement, the General Disclosure Package or the Prospectus, or incorporated by reference therein, regarding &#8220;non-GAAP financial measures&#8221; (as such term is defined by the rules and regulations of the Commission) comply with Regulation G
      of the 1934 Act, and Item 10 of Regulation S-K, to the extent applicable.&#160; The interactive data in eXtensible Business Reporting Language incorporated by reference in the Registration Statement, the General Disclosure Package and the Prospectus
      fairly presents the information called for in all material respects and has been prepared in accordance with the Commission's rules and guidelines applicable thereto.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">5</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ix)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Compliance with the Sarbanes-Oxley Act of 2002</u>.&#160; There is and has been no failure on the part of the Company or any of the Company&#8217;s
      directors or officers, in their capacities as such, to comply in all material respects with any provision of the Sarbanes-Oxley Act of 2002 and the rules and regulations promulgated in connection therewith, including Section 402 related to loans and
      Sections 302 and 906 related to certifications.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(x)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Material Adverse Change in Business</u>.&#160; Except as otherwise stated therein, since the respective dates as of which information is given in
      the Registration Statement, the General Disclosure Package or the Prospectus, (A)&#160;there has been no material adverse change in the condition, financial or otherwise, or in the earnings, business affairs or business prospects of the Company and its
      Subsidiary (as defined below) considered as one enterprise, whether or not arising in the ordinary course of business (a &#8220;<u>Material Adverse Effect</u>&#8221;), (B)&#160;there have been no transactions entered into by the Company or its Subsidiary, other than
      those in the ordinary course of business, which are material with respect to the Company and its Subsidiary considered as one enterprise, (C) there have been no material liabilities or obligations, direct or contingent, entered into by the Company or
      its Subsidiary and (D)&#160;there has been no dividend or distribution of any kind declared, paid or made by the Company on any class of its share capital.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xi)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Good Standing of the Company</u>.&#160; The Company has been duly organized and is validly existing as a corporation incorporated and registered
      under the laws of the State of Israel and has corporate power and authority to own, lease and operate its properties and to conduct its business as described in the Registration Statement, the General Disclosure Package and the Prospectus and to
      enter into and perform its obligations under this Agreement; and the Company is duly qualified as a foreign corporation to transact business and is in good standing in each other jurisdiction in which such qualification is required, whether by reason
      of the ownership or leasing of property or the conduct of business, except where the failure to be so qualified or to be in good standing would not result in a Material Adverse Effect.&#160; As of the date hereof, the Company is not designated as a
      &#8220;breaching company&#8221; by the Registrar of Companies of the State of Israel.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Good Standing of the Company&#8217;s Subsidiary</u>.&#160; The subsidiary of the Company (the &#8220;<u>Subsidiary</u>&#8221;) has been duly organized and is validly
      existing in good standing under the laws of the jurisdiction of its incorporation or organization, has corporate or similar power and authority to own, lease and operate its properties and to conduct its business as described in the Registration
      Statement, the General Disclosure Package and the Prospectus and is duly qualified to transact business and is in good standing in each jurisdiction in which such qualification is required, whether by reason of the ownership or leasing of property or
      the conduct of business, except where the failure to be so qualified or to be in good standing would not result in a Material Adverse Effect. The only Subsidiary of the Company is the entity listed on Exhibit 8.1 to the Company&#8217;s Annual Report on
      Form 20-F for the year ended December 31, 2019.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xiii)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Capitalization</u>.&#160; The authorized, issued and outstanding shares of the Company are as set forth in the Registration Statement, the General
      Disclosure Package and the Prospectus (except for subsequent issuances, if any, (A) pursuant to this Agreement, (B) pursuant to reservations, agreements or employee benefit plans referred to in the Registration Statement, the General Disclosure
      Package and the Prospectus or (C) pursuant to the conversion of convertible securities or exercise of options or warrants referred to in the Registration Statement, the General Disclosure Package and the Prospectus).&#160; The form of certificates for the
      Ordinary Shares conform to the law of the jurisdiction of the Company&#8217;s incorporation and to any requirements of the Company&#8217;s organizational documents.&#160; The outstanding shares of the Company and the Subsidiary have been duly authorized and are
      validly issued, fully paid and non&#8209;assessable, and were issued in compliance with all applicable United States federal and state and foreign securities laws, including the Israeli Securities Law (as defined below).&#160; None of the outstanding shares of
      the Company or the Subsidiary was issued in violation of any preemptive or other similar rights of any security holder of the Company or the Subsidiary, as applicable.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">6</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xiv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Authorization of Agreement</u>.&#160; This Agreement has been duly authorized, executed and delivered by the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u></u><u>Authorization and Description of Securities</u>.&#160; The Securities to be purchased by the Underwriters from the Company have been duly
      authorized for issuance and sale to the Underwriters pursuant to this Agreement and, when issued and delivered by the Company pursuant to this Agreement against payment of the consideration set forth herein, will be validly issued and fully paid and
      non&#8209;assessable; and the issuance of the Securities is not subject to any preemptive or other similar rights of any security holder of the Company.&#160; The Ordinary Shares conform in all material respects to the statements relating thereto contained in
      the Registration Statement, the General Disclosure Package and the Prospectus and such description conforms to the rights set forth in the instruments defining the same.&#160; No holder of Securities will be subject to personal liability by reason of
      being such a holder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xvi)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Registration Rights</u>.&#160; There are no persons with registration rights or other similar rights to have any securities registered for sale
      pursuant to the Registration Statement or otherwise registered for sale or sold by the Company under the 1933 Act pursuant to this Agreement, other than those rights that have been disclosed in the Registration Statement, the General Disclosure
      Package and the Prospectus and have been waived.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xvii)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Absence of Violations, Defaults and Conflicts</u>.&#160; Except as disclosed in the Registration Statement, General Disclosure Package and the
      Prospectus, to the Company&#8217;s knowledge, neither the Company nor its Subsidiary is (A) in violation of its memorandum of association, articles of association, charter, by-laws or similar organizational document, (B) in default in the performance or
      observance of any obligation, agreement, covenant or condition contained in any contract, indenture, mortgage, deed of trust, loan or credit agreement, note, lease or other agreement or instrument to which the Company or its Subsidiary is a party or
      by which either of them may be bound or to which any of the properties or assets of the Company or its Subsidiary is subject (collectively, &#8220;<u>Agreements and Instruments</u>&#8221;), except for such defaults that would not, singly or in the aggregate,
      result in a Material Adverse Effect, or (C) in violation of any law, statute, rule, regulation, judgment, order, writ or decree of any arbitrator, court, governmental body, regulatory body, administrative agency or other authority, body or agency
      having jurisdiction over the Company or its Subsidiary or any of their respective properties, assets or operations (each, a &#8220;<u>Governmental Entity</u>&#8221;), except for such violations that would not, singly or in the aggregate, result in a Material
      Adverse Effect.&#160; The execution, delivery and performance of this Agreement and the consummation of the transactions contemplated herein and in the Registration Statement, the General Disclosure Package and the Prospectus (including the issuance and
      sale of the Securities and the use of the proceeds from the sale of the Securities as described therein under the caption &#8220;Use of Proceeds&#8221;) and compliance by the Company with its obligations hereunder have been duly authorized by all necessary
      corporate action, including, to the extent applicable, under Chapter 5 of Part VI of the Israel Companies Law, 5759-1999, as amended (together with the regulations promulgated thereunder, the &#8220;<u>Israel Companies Law</u>&#8221;) and do not and will not,
      whether with or without the giving of notice or passage of time or both, conflict with or constitute a breach of, or default or Repayment Event (as defined below) under, or result in the creation or imposition of any lien, charge or encumbrance upon
      any properties or assets of the Company or its Subsidiary pursuant to, the Agreements and Instruments (except for such conflicts, breaches, defaults or Repayment Events or liens, charges or encumbrances that would not, singly or in the aggregate,
      result in a Material Adverse Effect), nor will such action result in any violation of the provisions of the memorandum of association, articles of association, charter, by-laws or similar organizational document of the Company or its Subsidiary or,
      except for such violations that would not, singly or in the aggregate, result in a Material Adverse Effect, any law, statute, rule, regulation, judgment, order, writ or decree of any Governmental Entity.&#160; As used herein, a &#8220;<u>Repayment Event</u>&#8221;
      means any event or condition which gives the holder of any note, debenture or other evidence of indebtedness (or any person acting on such holder&#8217;s behalf) the right to require the repurchase, redemption or repayment of all or a portion of such
      indebtedness by the Company or its Subsidiary.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">7</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xviii)&#160;&#160;&#160;&#160;&#160;&#160; <u>Listing</u>.&#160; The Securities have been approved for listing on the Nasdaq Global Market, subject to notice of issuance.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xix)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Absence of Labor Dispute</u>.&#160; Neither the Company nor its Subsidiary is involved in any labor dispute nor, to the knowledge of the Company, is
      any such dispute threatened, which dispute would reasonably be expected to have a Material Adverse Effect.&#160; The Company is not aware of any existing, imminent or threatened in writing labor disturbance by the employees of any of its principal
      suppliers or contractors which would reasonably be expected to have a Material Adverse Effect.&#160; The Company is not aware of any threatened or pending litigation between the Company or its Subsidiary and any of their executive officers which, if
      adversely determined, would reasonably be expected to have a Material Adverse Effect.&#160; The Company has fulfilled all its obligations under law, including under any applicable extension orders, to its employees, including with respect to payment of
      overtime under the Israeli Hours of Work and Rest Law, 1951, and severance pay under the&#160;Israeli Severance Pay Law, 5723-1963, except for any such breach that would not, singularly or in the aggregate, reasonably be expected to have a Material
      Adverse Effect.&#160; Other than pursuant to orders extending certain provisions of collective bargaining agreements between the Histadrut (General Federation of Labor in Israel) and the Coordinating Bureau of Economic Organization (the federation of
      employers&#8217; organizations) or otherwise as required by applicable law, the Company is not bound by or subject to (and none of its assets or properties are bound by or subject to) any written, oral, express or implied contract, commitment or
      arrangement with any labor union, and no labor union has requested or, to the Company&#8217;s knowledge, has sought to represent any of the employees of the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xx)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Absence of Proceedings</u>.&#160; There is no action, suit, proceeding, inquiry or investigation before or brought by any Governmental Entity
      (including, without limitation, any action, suit proceeding, inquiry or investigation before or brought by the U.S. Food and Drug Administration (the &#8220;<u>FDA</u>&#8221;) or the European Medicines Agency (the &#8220;<u>EMA</u>&#8221;)) now pending or, to the knowledge
      of the Company, threatened, against or affecting the Company or its Subsidiary, which would reasonably be expected to result in a Material Adverse Effect, or which would reasonably be expected to materially and adversely affect their respective
      properties or assets or the consummation of the transactions contemplated in this Agreement or the performance by the Company of its obligations hereunder; and the aggregate of all pending legal or governmental proceedings to which the Company or its
      Subsidiary is a party or of which any of their respective properties or assets is the subject which are not described in the Registration Statement, the General Disclosure Package and the Prospectus, including ordinary routine litigation incidental
      to the business, would not reasonably be expected to result in a Material Adverse Effect.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">8</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxi)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Accuracy of Exhibits</u>.&#160; There are no contracts or documents which are required to be described in the Registration Statement, the General
      Disclosure Package or the Prospectus or to be filed as exhibits to the Registration Statement which have not been so described and filed as required.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxii)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Absence of Further Requirements</u>.&#160; No filing with, or authorization, approval, consent, license, order, registration, qualification or
      decree of, any Governmental Entity is necessary or required for the performance by the Company of its obligations hereunder, in connection with the offering, issuance or sale of the Securities hereunder or the consummation of the transactions
      contemplated by this Agreement, except such as have been already obtained and are in full force and effect or as may be required under the 1933 Act, the 1933 Act Regulations, or the rules of the Nasdaq Stock Market LLC, the Tel Aviv Stock Exchange
      (including a final application for the listing of the Securities on the Tel Aviv Stock Exchange), U.S. state securities laws, the IIA (as such term is defined below), the Israeli Securities Authority (including the filing of all documents filed by
      the Company with the Commission in connection with the registration and offering of the Securities) or the Financial Industry Regulatory Authority, Inc. (&#8220;<u>FINRA</u>&#8221;).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxiii)&#160;&#160;&#160;&#160;&#160; <u>Consents and Permits</u>.&#160; Except for the filings referred to in Section 1(a)(xxii), the Company and its Subsidiary have made all filings,
      applications and submissions required by, possesses and is operating in compliance with, all approvals, licenses, certificates, certifications, clearances, consents, grants, exemptions, marks, notifications, orders, permits and other authorizations
      issued by, the appropriate federal, state or foreign, including Israeli, Governmental Entity (including, without limitation, the FDA, the United States Drug Enforcement Administration or any other foreign, federal, state, provincial, court or local
      government or regulatory authorities including self-regulatory organizations engaged in the regulation of clinical trials, pharmaceuticals, biologics or biohazardous substances or materials) necessary for the ownership or lease of their respective
      properties or to conduct its businesses as described in the Registration Statement, the General Disclosure Package and the Prospectus (collectively, &#8220;<u>Permits</u>&#8221;), except for such Permits the failure of which to possess, obtain or make the same
      would not reasonably be expected to have a Material Adverse Effect; the term &#8220;Permits&#8221; shall also include, without limitation, all orders, licenses or certificates relating to any approved research and development projects through the Israel
      Innovation Authority of the Ministry of Economy and Industry of the State of Israel (formerly known as the Office of the Chief Scientist) (the &#8220;<u>IIA</u>&#8221;).&#160; The Company and its Subsidiary are in compliance with the terms and conditions of all such
      Permits, except where the failure to be in compliance would not have a Material Adverse Effect; all of the Permits are valid and in full force and effect, except where any invalidity, individually or in the aggregate, would not be reasonably expected
      to have a Material Adverse Effect; and neither the Company nor its Subsidiary has received any written notice relating to the limitation, revocation, cancellation, suspension, modification or non-renewal of any such Permit which, singly or in the
      aggregate, if the subject of an unfavorable decision, ruling or finding, would have a Material Adverse Effect.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxiv)&#160;&#160;&#160;&#160;&#160; <u>Title to Property</u>.&#160; The Company and its Subsidiary has good and marketable title to all of the material real property owned by them and good
      title to all other material properties owned by them, in each case, free and clear of all mortgages, pledges, liens, security interests, claims, restrictions or encumbrances of any kind except such as (A) are described in the Registration Statement,
      the General Disclosure Package and the Prospectus or (B) do not, singly or in the aggregate, materially affect the value of such property and do not materially interfere with the use made and proposed to be made of such property by the Company or its
      Subsidiary; and all of the leases and subleases material to the business of the Company and its Subsidiary, considered as one enterprise, and under which the Company or its Subsidiary holds properties described in the Registration Statement, the
      General Disclosure Package or the Prospectus, are in full force and effect, and neither the Company nor its Subsidiary has any notice of any material claim of any sort that has been asserted by anyone adverse to the rights of the Company or its
      Subsidiary under any of the leases or subleases mentioned above, or affecting or questioning the rights of the Company or its Subsidiary to the continued possession of the leased or subleased premises under any such lease or sublease.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">9</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxv)&#160;&#160;&#160;&#160;&#160;&#160; <u>Intellectual Property</u>.&#160; To the Company&#8217;s knowledge, the Company and its Subsidiary own, or have obtained valid and enforceable licenses for,
      all patents, trademarks, trademark registrations, service marks, service mark registrations, trade names, copyrights, licenses, inventions, software, databases, know-how, Internet domain names, trade secrets and other unpatented and/or unpatentable
      proprietary or confidential information, systems or procedures, and other material intellectual property described in the Registration Statement, the General Disclosure Package and the Prospectus as being owned or licensed by them or which are
      necessary for the conduct of their respective businesses as currently conducted (collectively, &#8220;<u>Intellectual Property</u>&#8221;), and, except as described in the Registration Statement, the General Disclosure Package and the Prospectus, the Company is
      not aware of any claim to the contrary or any challenge by any other person to the rights of the Company and its Subsidiary with respect to the foregoing.&#160; To the Company&#8217;s knowledge, the Intellectual Property agreements described in the Registration
      Statement, the General Disclosure Package and the Prospectus are valid, binding upon, and enforceable by or against the parties thereto in accordance with their terms.&#160; The Company and its Subsidiary has complied in all material respects with, and is
      not in breach nor has received any asserted or threatened claim of breach of, any Intellectual Property agreement, except for any such breach that would not, singularly or in the aggregate, reasonably be expected to have a Material Adverse Effect,
      and the Company has no knowledge of any breach or anticipated breach by any other person of any Intellectual Property agreement, except for any such breach that would not, singularly or in the aggregate, reasonably be expected to have a Material
      Adverse Effect.&#160; To the Company&#8217;s knowledge, the Company&#8217;s and its Subsidiary&#8217;s businesses as now conducted does not infringe or conflict with any patents, trademarks, service marks, trade names, copyrights, trade secrets, licenses or other
      intellectual property or franchise right of any person, except for any such infringement or conflict that would not, singularly or in the aggregate, reasonably be expected to have a Material Adverse Effect.&#160; Neither the Company nor its Subsidiary has
      received any written claim alleging the infringement by the Company or its Subsidiary of any patent, trademark, service mark, trade name, copyright, trade secret, license in or other intellectual property right or franchise right of any person.&#160; The
      Company and its Subsidiary has taken reasonable steps to protect, maintain and safeguard its rights in all Intellectual Property, including the execution of appropriate nondisclosure and confidentiality agreements.&#160; To the Company&#8217;s knowledge, the
      consummation of the transactions contemplated by this Agreement will not result in the loss or impairment of or payment of any additional amounts with respect to, nor require the consent of any other person in respect of, the Company&#8217;s or its
      Subsidiary&#8217;s right to own, use, or hold for use any of the Intellectual Property as owned, used or held for use in the conduct of its business.&#160; The granted and issued Intellectual Property owned by the Company and its Subsidiary, have not been
      adjudged by a court of competent jurisdiction invalid or unenforceable, in whole or in part, and except as otherwise disclosed in the Registration Statement and the Prospectus, there is no pending or, to the Company&#8217;s knowledge, threatened action,
      suit, proceeding or claim by others challenging the validity or scope of any such Intellectual Property.&#160; To the Company&#8217;s knowledge, the Company and its Subsidiary is in compliance with all applicable laws relating to privacy, data protection, and
      the collection and use of personal information collected, used, or held for use by the Company or its Subsidiary in the conduct of the Company&#8217;s or the Subsidiary&#8217;s business, except for any such breach that would not, singularly or in the aggregate,
      reasonably be expected to have a Material Adverse Effect.&#160; No claims have been asserted or, to the Company&#8217;s knowledge, threatened against the Company or its Subsidiary alleging a violation of any person&#8217;s privacy or personal information or data
      rights and, to the Company&#8217;s knowledge, the consummation of the transactions contemplated by this Agreement will not breach or otherwise cause any violation of any law related to privacy, data protection, or the collection and use of personal
      information collected, used, or held for use by the Company or its Subsidiary in the conduct of the Company&#8217;s or any of its Subsidiary&#8217;s businesses, except in each case for any such violation or breach that would not, singularly or in the aggregate,
      reasonably be expected to have a Material Adverse Effect, and the Company and its Subsidiary take reasonable measures to ensure that such information is protected against unauthorized access, use, modification, or other misuse.&#160; The Company is not a
      party to or bound by any options, licenses or agreements with respect to the Intellectual Property of any other person or entity that are required to be set forth in the Registration Statement, the General Disclosure Package and the Prospectus and
      are not described therein or attached thereto as an exhibit.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">10</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxvi)&#160;&#160;&#160;&#160;&#160; <u>FDA Compliance</u>.&#160; Except as described in the Registration Statement, the General Disclosure Package and the Prospectus, the Company:&#160; (A) is
      and at all times has been in material compliance with all statutes, rules or regulations of the FDA and other comparable Governmental Entities applicable to the ownership, testing, development, manufacture, packaging, processing, use, distribution,
      marketing, labeling, promotion, sale, offer for sale, storage, import, export or disposal of any product under development, manufactured or distributed by the Company (&#8220;<u>Applicable Laws</u>&#8221;); (B) has not received any FDA Form 483, notice of
      adverse finding, warning letter, untitled letter or other correspondence or written notice from the FDA or any Governmental Entity alleging or asserting material noncompliance with any Applicable Laws or any licenses, certificates, approvals,
      clearances, exemptions, authorizations, permits and supplements or amendments thereto required by any such Applicable Laws (&#8220;<u>Authorizations</u>&#8221;); (C) possesses all material Authorizations and such Authorizations are valid and in full force and
      effect and the Company is not in material violation of any term of any such Authorizations; (D) has not received notice of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from the FDA or any
      Governmental Entity or third party alleging that any product operation or activity is in material violation of any Applicable Laws or Authorizations and has no knowledge that the FDA or any Governmental Entity or third party is considering any such
      claim, litigation, arbitration, action, suit, investigation or proceeding; (E) has not received notice that the FDA or any Governmental Entity has taken, is taking or intends to take action to limit, suspend, modify or revoke any material
      Authorizations and has no knowledge that the FDA or any Governmental Entity is considering such action; and (F) has filed, obtained, maintained or submitted all material reports, documents, forms, notices, applications, records, claims, submissions
      and supplements or amendments as required by any Applicable Laws or Authorizations and that all such reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments were materially complete and correct on
      the date filed (or were corrected or supplemented by a subsequent submission).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxvii)&#160;&#160;&#160;&#160;&#160; <u></u><u>Compliance with Health Care Laws</u>.&#160; The Company has operated and currently is in compliance with all applicable health care laws,
      rules and regulations (except where such failure to operate or non-compliance would not, singly or in the aggregate, reasonably be expected to result in a Material Adverse Effect), including, without limitation, (i) the Federal, Food, Drug and
      Cosmetic Act (21 U.S.C. &#167;&#167; 301 et seq.); (ii) all applicable federal, state, local and all applicable foreign healthcare related fraud and abuse laws, including, without limitation, the federal Anti-kickback Statute (42 U.S.C. &#167; 1320a-7b(b)), the
      U.S. Physician Payments Sunshine Act (42 U.S.C. &#167; 1320a-7h), the civil False Claims Act (31 U.S.C. &#167;&#167; 3729 et seq.), the criminal False Claims Law (42 U.S.C. &#167; 1320a-7b(a)), all criminal laws relating to healthcare fraud and abuse, including but not
      limited to 18 U.S.C. Sections 286 and 287, the healthcare fraud criminal provisions under the U.S. Health Insurance Portability and Accountability Act of 1996 (&#8220;<u>HIPAA</u>&#8221;) (42 U.S.C. Section 1320d et seq.), the exclusion law (42 U.S.C. &#167;
      1320a-7), and the civil monetary penalties law (42 U.S.C. &#167; 1320a-7a); (iii) HIPAA, as amended by the Health Information Technology for Economic Clinical Health Act (42 U.S.C. Section 17921 et seq.); (iv) the regulations promulgated pursuant to such
      laws; and (v) any other similar local, state, federal, or foreign laws (collectively, the &#8220;<u>Health Care Laws</u>&#8221;).&#160; Neither the Company, nor to the Company&#8217;s knowledge, any of its officers, directors, employees or agents have engaged in activities
      which are, as applicable, cause for false claims liability, civil penalties, or mandatory or permissive exclusion from Medicare, Medicaid, or any other state or federal healthcare program.&#160; The Company has not received written notice of any claim,
      action, suit, audit, survey, proceeding, hearing, enforcement, investigation, arbitration or other action&#160; (&#8220;<u>Action</u>&#8221;) from any Governmental Entity or third party alleging that any product operation or activity is in violation of any Health
      Care Laws, and, to the Company&#8217;s knowledge, no such claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action is threatened.&#160; The Company is not a party to and does not have any ongoing reporting obligations
      pursuant to any corporate integrity agreement, deferred prosecution agreement, monitoring agreement, consent decree, settlement order, plan of correction or similar agreement imposed by any Governmental Entity.&#160; Additionally, neither the Company,
      nor, to the Company&#8217;s knowledge, any of its employees, officers or directors, has been excluded, suspended or debarred from participation in any U.S. state or federal health care program or human clinical research or, to the knowledge of the Company,
      is subject to a governmental inquiry, investigation, proceeding, or other similar action that would reasonably be expected to result in debarment, suspension, or exclusion.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">11</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxviii)&#160;&#160;&#160;&#160; <u>Environmental Laws</u>.&#160; Except as described in the Registration Statement, the General Disclosure Package and the Prospectus or would not,
      singly or in the aggregate, reasonably be expected to result in a Material Adverse Effect, (A) neither the Company nor its Subsidiary is in violation of any federal, state, local or foreign, including Israeli, statute, law, rule, regulation,
      ordinance, code, policy or rule of common law or any judicial or administrative interpretation thereof, including any judicial or administrative order, consent, decree or judgment, relating to pollution or protection of human health, the environment
      (including, without limitation, ambient air, surface water, groundwater, land surface or subsurface strata) or wildlife, including, without limitation, laws and regulations relating to the release or threatened release of chemicals, pollutants,
      contaminants, wastes, toxic substances, hazardous substances, petroleum or petroleum products, asbestos-containing materials or mold (collectively, &#8220;<u>Hazardous Materials</u>&#8221;) or to the manufacture, processing, distribution, use, treatment,
      storage, disposal, transport or handling of Hazardous Materials (collectively, &#8220;<u>Environmental Laws</u>&#8221;), (B) the Company and its Subsidiary has all permits, authorizations and approvals required under any applicable Environmental Laws and are
      each in compliance with their requirements, (C) there are no pending or, to the knowledge of the Company threatened, administrative, regulatory or judicial actions, suits, demands, demand letters, claims, liens, notices of noncompliance or violation,
      investigation or proceedings relating to any Environmental Law against the Company or its Subsidiary and (D) there are no events or circumstances that would reasonably be expected to form the basis of an order for clean-up or remediation, or an
      action, suit or proceeding by any private party or Governmental Entity, against or affecting the Company or its Subsidiary relating to Hazardous Materials or any Environmental Laws.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxix)&#160;&#160;&#160;&#160;&#160; <u>Accounting Controls and Disclosure Controls</u>.&#160; The Company and its Subsidiary maintain effective internal control over financial reporting (as
      defined under Rule 13&#8209;a15 and 15d&#8209;15 under the rules and regulations of the Commission under the 1934 Act Regulations) and a system of internal accounting controls sufficient to provide reasonable assurances that (A)&#160;transactions are executed in
      accordance with management&#8217;s general or specific authorization; (B)&#160;transactions are recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain accountability for assets; (C) access to assets is
      permitted only in accordance with management&#8217;s general or specific authorization; (D) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences;
      and (E) the interactive data in eXtensible Business Reporting Language incorporated by reference in the Registration Statement, the General Disclosure Package and the Prospectus fairly presents the information called for in all material respects and
      is prepared in accordance with the Commission&#8217;s rules and guidelines applicable thereto.&#160; Except as described in the Registration Statement, the General Disclosure Package and the Prospectus, since the end of the Company&#8217;s most recent audited fiscal
      year, there has been (1) no material weakness in the Company&#8217;s internal control over financial reporting (whether or not remediated) and (2) no change in the Company&#8217;s internal control over financial reporting that has materially adversely affected,
      or is reasonably likely to materially adversely affect, the Company&#8217;s internal control over financial reporting.&#160; The Company and its Subsidiary maintain an effective system of disclosure controls and procedures (as defined in Rule 13a&#8209;15 and Rule
      15d&#8209;15 under the 1934 Act Regulations) that are designed to ensure that information required to be disclosed by the Company in the reports that it files or submits under the 1934 Act is recorded, processed, summarized and reported, within the time
      periods specified in the Commission&#8217;s rules and forms, and is accumulated and communicated to the Company&#8217;s management, including its principal executive officer or officers and principal financial officer or officers, as appropriate, to allow timely
      decisions regarding disclosure.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">12</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxx)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Clinical Trials</u>.&#160; To the Company&#8217;s knowledge, all nonclinical studies and clinical trials conducted by or on behalf of or sponsored by the
      Company, with respect to the Company&#8217;s product candidates, including any such studies and trials that are described in the Prospectus, or the results of which are referred to in the Prospectus, as applicable (collectively, &#8220;<u>Company Trials</u>&#8221;),
      were, and if still pending are, being conducted in all material respects in accordance with all Applicable Laws; the descriptions in the Prospectus of the results of any Company Trials are accurate and complete descriptions in all material respects
      and fairly present the data derived therefrom; the Company has no knowledge of any other studies or trials not described in the Prospectus, the results of which are materially inconsistent with or call into question the results described or referred
      to in the Prospectus; the Company is currently in compliance in all material respects with all Applicable Laws; the Company has not received, nor does it have knowledge that any of its collaboration partners has received, any written notices,
      correspondence or other written communications from the FDA, the Israeli Ministry of Health or any other Governmental Entity requiring or threatening the termination, material modification or suspension of Company Trials, other than ordinary course
      communications with respect to modifications in connection with the design and implementation of such studies or trials.&#160; To the extent required by Applicable Law, the Company has obtained (or caused to be obtained) the informed consent of each human
      subject who participated in a Company Trial.&#160; To the Company&#8217;s knowledge, the operations of its contractors, suppliers and manufacturing facilities are conducted in compliance in all material respects with Applicable Laws.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxi)&#160;&#160;&#160;&#160;&#160;&#160; <u>Taxes</u>.&#160; The Company and its Subsidiary have filed all U.S. federal, state, local and foreign, including Israeli, tax returns which have been
      required to be filed and paid all taxes shown thereon through the date hereof, to the extent that such taxes have become due and are not being contested in good faith, in each case except where the failure to so file or pay would not reasonably be
      expected to have a Material Adverse Effect.&#160; Except as otherwise disclosed in or contemplated by the Registration Statement, the General Disclosure Package and the Prospectus, no unpaid tax deficiency has been determined adversely to the Company or
      its Subsidiary which has had, or would have reasonably be expected to, individually or in the aggregate, a Material Adverse Effect.&#160; The Company has no knowledge of any U.S. federal, state or other governmental tax deficiency, penalty or assessment
      which has been asserted or threatened against it in writing which would reasonably be expected to have a Material Adverse Effect.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">13</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxii)&#160;&#160;&#160;&#160; <u>Insurance</u>.&#160; The Company and its Subsidiary carry or are entitled to the benefits of insurance, with insurers of recognized financial
      responsibility, in such amounts and covering such risks as is adequate for the conduct of their respective businesses and the value of their respective properties and as is customary for companies engaged in similar businesses in similar industries;
      all policies of insurance owned by the Company or its Subsidiary is in full force and effect.&#160; The Company has no reasonable basis to believe that it or the Subsidiary will not be able (i) to renew its existing insurance coverage as and when such
      policies expire or (ii) to obtain comparable coverage from similar institutions as may be necessary or appropriate to conduct its business as now conducted and at a cost that could not reasonably be expected to have a Material Adverse Effect.&#160;
      Neither the Company nor the Subsidiary has been denied any material insurance coverage which it has sought or for which it has applied.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxiii)&#160;&#160;&#160; <u>Investment Company Act</u>.&#160; The Company is not required, and upon the issuance and sale of the Securities as herein contemplated and the
      application of the net proceeds therefrom as described in the Registration Statement, the General Disclosure Package and the Prospectus will not be required, to register as an &#8220;investment company&#8221; under the Investment Company Act of 1940, as amended.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxiv)&#160;&#160;&#160; <u>Certain Market Activities</u>.&#160; The Company has not taken, nor will it take, directly or indirectly, any action designed to or which might
      reasonably be expected to cause or result in, or which has constituted or which might reasonably be expected to constitute, the stabilization or manipulation of the price of the Ordinary Shares or any security of the Company to facilitate the sale or
      resale of any of the Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxv)&#160;&#160;&#160;&#160; <u>Foreign Corrupt Practices Act</u>.&#160; None of the Company, its Subsidiary or, to the knowledge of the Company, any director, officer, agent,
      employee, affiliate or other person acting on behalf of the Company or its Subsidiary is aware of or has taken any action, directly or indirectly, that would result in a violation by such persons of the Foreign Corrupt Practices Act of 1977, as
      amended, and the rules and regulations thereunder (the &#8220;<u>FCPA</u>&#8221;), or Section 291 or 291A of the Israel Penal Law, 1977 (&#8220;<u>Israeli FCPA</u>&#8221;), including, without limitation, making use of the mails or any means or instrumentality of interstate
      commerce corruptly in furtherance of an offer, payment, promise to pay or authorization of the payment of any money, or other property, gift, promise to give, or authorization of the giving of anything of value to any &#8220;foreign official&#8221; (as such term
      is defined in the FCPA) or any foreign political party or official thereof or any candidate for foreign political office, in contravention of the FCPA or the Israeli FCPA and the Company and its Subsidiary have conducted their businesses in
      compliance with the FCPA and the Israeli FCPA and have instituted and maintain policies and procedures designed to ensure, and which are reasonably expected to continue to ensure, continued compliance therewith.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxvi)&#160;&#160;&#160; <u>Money Laundering Laws</u>.&#160; The operations of the Company and its Subsidiary are and have been conducted at all times in compliance with
      applicable financial recordkeeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money laundering statutes of all applicable jurisdictions, the rules and regulations thereunder and any
      related or similar rules, regulations or guidelines, issued, administered or enforced by any Governmental Entity (collectively, the &#8220;<u>Money Laundering Laws</u>&#8221;); and no action, suit or proceeding by or before any Governmental Entity involving the
      Company or its Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge of the Company, threatened.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">14</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxvii)&#160;&#160; <u>OFAC</u>.&#160; None of the Company, its Subsidiary or, to the knowledge of the Company, any director, officer, agent, employee, affiliate or
      representative of the Company or its Subsidiary is an individual or entity (&#8220;<u>Person</u>&#8221;) currently the subject or target of any sanctions administered or enforced by the United States Government, including, without limitation, the U.S. Department
      of the Treasury&#8217;s Office of Foreign Assets Control, the United Nations Security Council, the European Union, Her Majesty&#8217;s Treasury, or other relevant sanctions authority (collectively, &#8220;<u>Sanctions</u>&#8221;), nor is the Company located, organized or
      resident in a country or territory that is the subject of Sanctions; and the Company will not directly or indirectly use the proceeds of the sale of the Securities, or lend, contribute or otherwise make available such proceeds to its Subsidiary or
      any joint venture partners or other Person, to fund any activities of or business with any Person, or in any country or territory, that, at the time of such funding, is the subject of Sanctions prohibiting such activities or business or in any other
      manner that will result in a violation by any Person (including any Person participating in the transaction, whether as underwriter, advisor, investor or otherwise) of Sanctions.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxviii)&#160; <u>Lending Relationship</u><font style="font-style: italic;">.&#160; </font>The Company (i)&#160;does not have any&#160;material lending or other relationship with
      any banking or lending affiliate of any Underwriter and (ii)&#160;does not intend to use any of the proceeds from the sale of the Securities to repay any outstanding debt owed to any affiliate of any Underwriter.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xxxix)&#160;&#160;&#160; <u>Statistical and Market-Related Data</u>.&#160; Any statistical and market-related data included in the Registration Statement, the General Disclosure
      Package or the Prospectus are based on or derived from sources that the Company believes to be reliable and accurate and, to the extent required, the Company has obtained the written consent to the use of such data from such sources.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xl)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Maintenance of Rating</u>.&#160; The Company has no debt securities or preferred stock that is rated by any &#8220;nationally recognized statistical rating
      organization&#8221; (as that term is defined by the Commission for purposes of Rule 436(g)(2) under the 1933 Act).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xli)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Privacy and Data Protection</u>.&#160; The Company and its Subsidiary have operated their business in a manner compliant in all respects with all
      United States federal, state, local and non-United States privacy, data security and data protection laws and regulations applicable to the Company&#8217;s collection, use, transfer, protection, disposal, disclosure, handling, storage and analysis of
      personal data, except where the failure to so comply would not reasonably be expected, singly or in the aggregate, result in a Material Adverse Effect.&#160; The Company and its Subsidiary have been and are in compliance in all respects with internal
      policies and procedures designed to ensure the integrity and security of the data collected, handled or stored in connection with its business, except where the failure to so comply would not reasonably be expected, singly or in the aggregate, result
      in a Material Adverse Effect; the Company and its Subsidiary have been and are in compliance in all respects with internal policies and procedures designed to ensure compliance with the Health Care Laws that govern privacy and data security and take,
      and have taken reasonably appropriate steps designed to assure compliance with such policies and procedures, except where the failure to so comply would not reasonably be expected, singly or in the aggregate, result in a Material Adverse Effect.&#160; The
      Company and its Subsidiary have taken reasonable steps to maintain the confidentiality of personally identifiable information, protected health information, consumer information and other confidential information of the Company, its Subsidiary and
      any third parties in its possession (&#8220;<u>Sensitive Company Data</u>&#8221;).&#160; The tangible or digital information technology systems (including computers, screens, servers, workstations, routers, hubs, switches, networks, data communications lines,
      technical data and hardware), software and telecommunications systems used or held for use by the Company and its Subsidiary (the &#8220;<u>Company IT Assets</u>&#8221;) are adequate and operational, in all material respects, for, in accordance with their
      documentation and functional specifications, the business of the Company and its Subsidiary as now operated and as currently proposed to be conducted as described in the Registration Statement, the General Disclosure Package and the Prospectus.&#160; The
      Company and its Subsidiary have used reasonable efforts to establish, and have established, commercially reasonable disaster recovery and security plans, procedures and facilities for the business consistent with industry standards and practices in
      all material respects, including, without limitation, for the Company IT Assets and data held or used by or for the Company and its Subsidiary.&#160; Neither the Company nor its Subsidiary have suffered or incurred any security breaches, compromises or
      incidents with respect to any Company IT Asset or Sensitive Company Data, except where such breaches, compromises or incidents would not reasonably be expected to, singly or in the aggregate, result in a Material Adverse Effect; and, to the Company&#8217;s
      knowledge, there has been no unauthorized or illegal use of or access to any Company IT Asset or Sensitive Company Data by any unauthorized third party.&#160; The Company and its Subsidiary have not been required to notify any individual of any material
      information security breach, compromise or incident involving Sensitive Company Data.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">15</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xlii)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>No Broker Fees</u>.&#160; Except as disclosed in the General Disclosure Package, there are no contracts, agreements or understandings between the
      Company and any person that would give rise to a valid claim against the Company or any Underwriter for a brokerage commission, finder&#8217;s fee or other like payment in connection with the offering of the Securities contemplated hereby.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xliii)&#160;&#160;&#160;&#160;&#160;&#160; <u>Israeli Programs</u>.&#160; Except as set forth in the Registration Statement, the General Disclosure Package and the Prospectus Supplement and the
      Prospectus, neither the Company nor its Subsidiary has received any grant from the IIA or any other Israeli governmental or regulatory authority, including the Investment Center of the Ministry of Economy and Industry of the State of Israel.&#160; The
      Company has not received any notice denying, revoking or modifying any &#8220;Approved Enterprise,&#8221; &#8220;Benefited Enterprise,&#8221; &#8220;Preferred Enterprise,&#8221; &#8220;Preferred Technology Enterprise&#8221; or &#8220;Special Preferred Technology Enterprise&#8221; status or benefits with
      respect to any of the Company&#8217;s facilities or operations (collectively and together with the grants approved or received by the IIA, the &#8220;<u>Governmental Grant</u>&#8221;).&#160; No event has occurred, and no circumstance or condition exists, that would
      reasonably be expected to give rise to or serve as the basis for (i) the annulment, revocation, withdrawal, suspension, cancellation, recapture or modification of the Governmental Grant, (ii) the imposition of any material limitation on the
      Governmental Grant or (iii) a requirement that the Company return or refund any benefits provided under the Governmental Grant.&#160; All information supplied by the Company with respect to the applications or notifications relating to Governmental Grant
      was true, correct and complete in all material respects when supplied to the appropriate authorities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xliv)&#160;&#160;&#160;&#160;&#160;&#160; <u>Israeli Securities Laws</u>. The Company has not engaged and will not engage in any form of solicitation, advertising or any other action
      constituting an offer or sale under the Israel Securities Law, 5728-1968, as amended and the regulations promulgated thereunder (&#8220;<u>Israeli Securities Law</u>&#8221;) in connection with the transactions contemplated hereby which would require the Company
      to publish a prospectus in the State of Israel under the laws of the State of Israel. The Underwriters acknowledge and agree that they will purchase, accept delivery of and make payment for the Securities outside of the State of Israel and that the
      Securities may be sold in Israel by the Underwriters only to such Israeli investors listed on the First Addendum of the Israel Securities Law (the &#8220;<font style="font-weight: bold;">Addendum</font>&#8221;) and who submit written confirmation to the
      Underwriters and the Company prior to any purchase that such investor (i) falls within the scope of the Addendum, understands the meaning of falling within such scope and gives their consent thereto and (ii) is acquiring the Securities for investment
      for its own account or, if applicable, for investment for clients who are investors listed in the Addendum and in any event not as a nominee, market maker or agent and not with a view to, or for the resale in connection with, any distribution
      thereof.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">16</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xlv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Immunity</u>.&#160; Neither the Company nor its properties or assets has immunity under the State of Israel, U.S. federal or New York state law
      from any legal action, suit or proceeding, from the giving of any relief in any such legal action, suit or proceeding, from set-off or counterclaim, from the jurisdiction of the State of Israel, U.S. federal or New York state court, from service of
      process, attachment upon or prior to judgment, or attachment in aid of execution of judgment, or from execution of a judgment, or other legal process or proceeding for the giving of any relief or for the enforcement of a judgment, in any such court
      with respect to their respective obligations, liabilities or any other matter under or arising out of or in connection herewith; and, to the extent that the Company or any of its properties, assets or revenues may have or may hereafter become
      entitled to any such right of immunity in any such court in which proceedings arising out of, or relating to the transactions contemplated by this Agreement, may at any time be commenced, the Company has, pursuant to this Agreement, waived, and it
      will waive such right to the extent permitted by law.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xlvi)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Agent for Service of Process</u>.&#160; The Company has duly designated Compugen USA, Inc., as its authorized agent to receive service of process as
      set forth in Section 17.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xlvii)&#160;&#160;&#160;&#160;&#160;&#160; <u>Choice of Law; Submission of Jurisdiction</u>.&#160; The choice of laws of the State of New York as the governing law of this Agreement is a valid
      choice of law under the laws of the State of Israel.&#160; The Company has the power to submit and, pursuant to Section 17 of this Agreement, has validly and irrevocably submitted to the personal jurisdiction of each Specified Court (as defined below) and
      to the exclusive jurisdiction of any court sitting therein.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xlviii)&#160;&#160;&#160;&#160;&#160; <u>Enforcement of Judgments</u>.&#160; Subject to the conditions and qualifications set forth in the Registration Statement, the General Disclosure
      Package and the Prospectus, a final and conclusive judgment against the Company for a definitive sum of money entered by any court in the United States may be enforced by an Israeli court.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(xlix)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Israeli Exemptions</u>.&#160; Other than to offers made to investors who are specified in and qualified under Section 15A(b) of the Israeli
      Securities Law and offers made to employees of the Company or any subsidiary of the Company pursuant to an exemption issued by the Israel Securities Authority pursuant to Section 15D of the Israeli Securities Law, there were no more than 35 offerees,
      in the aggregate, to whom the Company and any of its representatives made an offer in Israel of any securities of the Company in the past 12 months.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(l)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Israel Companies Law</u>. The Company has been and is in compliance with the provisions of the Israel Companies Law, except for such
      violations which, singly or in the aggregate, would not have a Material Adverse Effect.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Officer&#8217;s Certificates</font>.&#160; Any certificate signed by any officer of the Company or its Subsidiary in connection with the
      Offering of the Securities, including pursuant to this Agreement, and delivered to the Representatives or to counsel for the Underwriters shall be deemed a representation and warranty by the Company to each Underwriter as to the matters covered
      thereby.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">17</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 2.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Sale and Delivery to Underwriters; Closing</u>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Initial Securities</font>.&#160; On the basis of the representations and warranties herein contained and subject to the terms and
      conditions herein set forth, the Company agrees to sell to each Underwriter, severally and not jointly, and each Underwriter, severally and not jointly, agrees to purchase from the Company, at the price per share set forth in <u>Schedule&#160;A</u>, that
      number of Initial Securities set forth in <u>Schedule&#160;A</u> opposite the name of such Underwriter, plus any additional number of Initial Securities which such Underwriter may become obligated to purchase pursuant to the provisions of Section 10
      hereof, subject, in each case, to such adjustments among the Underwriters as the Representatives in their sole discretion shall make to eliminate any sales or purchases of fractional shares.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Option Securities</font>.&#160; In addition, on the basis of the representations and warranties herein contained and subject to the terms
      and conditions herein set forth, the Company hereby grants an option to the Underwriters, severally and not jointly, to purchase up to an additional 1,250,000 Ordinary Shares, at the price per share set forth in <u>Schedule&#160;A</u>, less an amount per
      share equal to any dividends or distributions declared by the Company and payable on the Initial Securities but not payable on the Option Securities.&#160; The option hereby granted may be exercised for 30&#160;days after the date hereof and may be exercised
      in whole or in part at any time from time to time upon notice by the Representatives to the Company setting forth the number of Option Securities as to which the several Underwriters are then exercising the option and the time and date of payment and
      delivery for such Option Securities.&#160; Any such time and date of delivery (a &#8220;<u>Date of Delivery</u>&#8221;) shall be determined by the Representatives, but any Date of Delivery after the Closing Time shall not be later than seven full business days nor
      earlier than two full business days after the exercise of said option, nor in any event prior to the Closing Time.&#160; If the option is exercised as to all or any portion of the Option Securities, each of the Underwriters, acting severally and not
      jointly, will purchase that proportion of the total number of Option Securities then being purchased which the number of Initial Securities set forth in <u>Schedule A</u> opposite the name of such Underwriter bears to the total number of Initial
      Securities, subject, in each case, to such adjustments as the Representatives in their sole discretion shall make to eliminate any sales or purchases of fractional shares.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Payment</font>.&#160; Payment of the purchase price for, and delivery of certificates or security entitlements for, the Initial Securities
      shall be made at the offices of Covington &amp; Burling LLP, The New York Times Building, 620 Eighth Avenue, New York, New York, 10018 or at such other place as shall be agreed upon by the Representatives and the Company, at 10:00&#160;A.M. (New York City
      time) on the second (third, if the pricing occurs after 4:30 P.M. (New York City time) on any given day) business day after the date hereof (unless postponed in accordance with the provisions of Section&#160;10), or such other time not later than ten
      business days after such date as shall be agreed upon by the Representatives and the Company (such time and date of payment and delivery being herein called &#8220;<u>Closing Time</u>&#8221;).&#160; Delivery of the Initial Securities at the Closing Time shall be made
      through the facilities of The Depository Trust Company unless the Representatives shall otherwise instruct.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In addition, in the event that any or all of the Option Securities are purchased by the Underwriters, payment of the purchase price for, and delivery of certificates or security
      entitlements for, such Option Securities shall be made at the above&#8209;mentioned offices, or at such other place as shall be agreed upon by the Representatives and the Company, on each Date of Delivery as specified in the notice from the Representatives
      to the Company.&#160; Delivery of the Option Securities on each such Date of Delivery shall be made through the facilities of The Depository Trust Company unless the Representatives shall otherwise instruct.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Payment shall be made to the Company by wire transfer of immediately available funds to a bank account designated by the Company, against delivery to the Representatives for the
      respective accounts of the Underwriters of certificates or security entitlements for the Securities to be purchased by them.&#160; It is understood that each Underwriter has authorized the Representatives, for their accounts, to accept delivery of,
      receipt for, and make payment of the purchase price for, the Initial Securities and the Option Securities, if any, which it has agreed to purchase.&#160; Each of SVB Leerink and Stifel, individually and not as Representatives of the Underwriters, may (but
      shall not be obligated to) make payment of the purchase price for the Initial Securities or the Option Securities, if any, to be purchased by any Underwriter whose funds have not been received by the Closing Time or the relevant Date of Delivery, as
      the case may be, but such payment shall not relieve such Underwriter from its obligations hereunder.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">18</font></div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 3.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Covenants of the Company</u>.&#160; The Company covenants with each Underwriter as follows:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Compliance with Securities Regulations and Commission Requests</font>.&#160; The Company, subject to Section 3(b), will comply with the
      requirements of Rule 430B, and will notify the Representatives as soon as practicable, and confirm the notice in writing, (i) when any post-effective amendment to the Registration Statement shall become effective or any amendment or supplement to the
      Prospectus shall have been filed, (ii)&#160;of the receipt of any comments from the Commission, (iii)&#160;of any request by the Commission for any amendment to the Registration Statement or any amendment or supplement to the Prospectus (including any document
      incorporated by reference therein) or for additional information, (iv)&#160;of the issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement or any post-effective amendment or of any order preventing or
      suspending the use of any preliminary prospectus or the Prospectus, or of the suspension of the qualification of the Securities for offering or sale in any jurisdiction, or of the initiation or threatening of any proceedings for any of such purposes
      or of any examination pursuant to Section 8(d) or 8(e) of the 1933 Act concerning the Registration Statement and (v) if the Company becomes the subject of a proceeding under Section 8A of the 1933 Act in connection with the offering of the
      Securities. The Company will effect all filings required under Rule 424(b), in the manner and within the time period required by Rule 424(b) (without reliance on Rule 424(b)(8)), and will take such steps as it deems necessary to ascertain promptly
      whether the form of prospectus transmitted for filing under Rule 424(b) was received for filing by the Commission and, in the event that it was not, it will promptly file such prospectus.&#160; The Company will make every reasonable effort to prevent the
      issuance of any stop order, prevention or suspension and, if any such order is issued, to obtain the lifting thereof at the earliest possible moment.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Continued Compliance with Securities Laws</font>.&#160; The Company will comply with the 1933 Act, the 1933 Act Regulations, the 1934 Act
      and the 1934 Act Regulations so as to permit the completion of the distribution of the Securities as contemplated in this Agreement and in the Registration Statement, the General Disclosure Package and the Prospectus.&#160; If at any time when a
      prospectus relating to the Securities is (or, but for the exception afforded by Rule 172 of the 1933 Act Regulations (&#8220;<u>Rule 172</u>&#8221;), would be) required by the 1933 Act to be delivered in connection with sales of the Securities, any event shall
      occur or condition shall exist as a result of which it is necessary, in the opinion of counsel for the Underwriters or for the Company, to (i)&#160;amend the Registration Statement in order that the Registration Statement will not include an untrue
      statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading, (ii) amend or supplement the General Disclosure Package or the Prospectus in order that the
      General Disclosure Package or the Prospectus, as the case may be, will not include any untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein not misleading in the light of the
      circumstances existing at the time it is delivered to a purchaser or (iii) amend the Registration Statement or amend or supplement the General Disclosure Package or the Prospectus, as the case may be, in order to comply with the requirements of the
      1933 Act or the 1933 Act Regulations, the Company will promptly (A) give the Representatives notice of such event, (B) prepare any amendment or supplement as may be necessary to correct such statement or omission or to make the Registration
      Statement, the General Disclosure Package or the Prospectus comply with such requirements and, a reasonable amount of time prior to any proposed filing or use, furnish the Representatives with copies of any such amendment or supplement and (C) file
      with the Commission any such amendment or supplement; provided that the Company shall not file or use any such amendment or supplement to which the Representatives or counsel for the Underwriters shall object.&#160; The Company will furnish to the
      Underwriters such number of copies of such amendment or supplement as the Underwriters may reasonably request.&#160; The Company has given the Representatives notice of any filings made pursuant to the 1934 Act or the 1934 Act Regulations within 48 hours
      prior to the Applicable Time; the Company will give the Representatives notice of its intention to make any such filing from the Applicable Time to the Closing Time and will furnish the Representatives with copies of any such documents a reasonable
      amount of time prior to such proposed filing, as the case may be, and will not file or use any such document to which the Representatives or counsel for the Underwriters shall reasonably object.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">19</font></div>
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    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Delivery of Registration Statements</font>.&#160; If requested by the Representatives, the Company will furnish or will deliver to the
      Representatives and counsel for the Underwriters, without charge, signed copies of the Registration Statement as originally filed and each amendment thereto (including exhibits filed therewith or incorporated by reference therein and documents
      incorporated or deemed incorporated by reference therein) and signed copies of all consents and certificates of experts, and will also deliver to the Representatives, without charge, a conformed copy of the Registration Statement as originally filed
      and each amendment thereto (without exhibits) for each of the Underwriters.&#160; The copies of the Registration Statement and each amendment thereto furnished to the Underwriters will be identical to the electronically transmitted copies thereof filed
      with the Commission pursuant to EDGAR, except to the extent permitted by Regulation S&#8209;T.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Delivery of Prospectuses</font>.&#160; The Company has delivered to each Underwriter, without charge, as many copies of each preliminary
      prospectus as such Underwriter reasonably requested, and the Company hereby consents to the use of such copies for purposes permitted by the 1933 Act.&#160; The Company will furnish to each Underwriter, without charge, during the period when a prospectus
      relating to the Securities is (or, but for the exception afforded by Rule 172, would be) required to be delivered under the 1933 Act, such number of copies of the Prospectus (as amended or supplemented) as such Underwriter may reasonably request.&#160;
      The Prospectus and any amendments or supplements thereto furnished to the Underwriters will be identical to the electronically transmitted copies thereof filed with the Commission pursuant to EDGAR, except to the extent permitted by Regulation S&#8209;T.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Blue Sky Qualifications</font>.&#160; The Company will use its best efforts, in cooperation with the Underwriters, to qualify the
      Securities for offering and sale under the applicable securities laws of such states and other jurisdictions (domestic or foreign) as the Representatives may designate and to maintain such qualifications in effect so long as required to complete the
      distribution of the Securities; provided, however, that the Company shall not be obligated to file any general consent to service of process or to qualify as a foreign corporation or as a dealer in securities in any jurisdiction in which it is not so
      qualified or to subject itself to taxation in respect of doing business in any jurisdiction in which it is not otherwise so subject.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Rule 158</font>.&#160; The Company will timely file such reports pursuant to the 1934 Act as are necessary in order to make generally
      available to its security holders as soon as practicable an earning statement for the purposes of, and to provide to the Underwriters the benefits contemplated by, the last paragraph of Section 11(a) of the 1933 Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Use of Proceeds</font>.&#160; The Company will use the net proceeds received by it from the sale of the Securities in all material
      respects in the manner specified in the Registration Statement, the General Disclosure Package and the Prospectus under the heading &#8220;Use of Proceeds.&#8221;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">20</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Listing</font>.&#160; The Company will use its reasonable best efforts to effect and maintain the listing of the Ordinary Shares
      (including the Securities) on the Nasdaq Global Market and to receive final approval for listing of the Securities on the Tel Aviv Stock Exchange.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Restriction on Sale of Securities</font>.&#160; During a period of 90 days from the date of the Prospectus, the Company will not, without
      the prior written consent of the Representatives, (i) directly or indirectly, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase or
      otherwise transfer or dispose of any Ordinary Shares or any securities convertible into or exercisable or exchangeable for Ordinary Shares or file or confidentially submit any registration statement under the 1933 Act with respect to any of the
      foregoing, (ii)&#160;enter into any swap or any other agreement or any transaction that transfers, in whole or in part, directly or indirectly, the economic consequence of ownership of Ordinary Shares, whether any such swap or transaction described in
      clause (i) or (ii) above is to be settled by delivery of Ordinary Shares or such other securities, in cash or otherwise or (iii) publicly announce an intention to effect any such swap, agreement or other transaction described in clauses (i) and
      (ii).&#160; The foregoing sentence shall not apply to (A) the Securities to be sold hereunder; (B) any Ordinary Shares issued by the Company upon the exercise of an option or warrant, or reissuance of such options or warrants upon transfer or assignment,&#160;
      or the conversion of a convertible security outstanding on the date hereof and referred to in the Registration Statement, the General Disclosure Package and the Prospectus; (C) any Ordinary Shares issued or options to purchase Ordinary Shares granted
      pursuant to existing employee benefit plans of the Company referred to in the Registration Statement, the General Disclosure Package and the Prospectus; (D) any Ordinary Shares issued pursuant to any existing non-employee director stock plan or
      dividend reinvestment plan referred to in the Registration Statement, the General Disclosure Package and the Prospectus; (E) the filing by the Company of any registration statement on Form S-8 or a successor form thereto; or (F) the issuance of
      Ordinary Shares or any securities convertible into or exercisable or exchangeable for Ordinary Shares, which Ordinary Shares and securities shall represent, in aggregate, not more than 5% of the Ordinary Shares outstanding at the Closing Time,
      pursuant to one or more strategic collaborations, licensing transactions or business, product or technology acquisitions (but excluding transactions principally of a financing nature); <font style="font-style: italic;">provided</font>, <font style="font-style: italic;">however</font>, that any such issuances under this clause (F) shall be conditioned upon the execution by each recipient of such Ordinary Shares or securities convertible into or exercisable or exchangeable for Ordinary
      Shares of a lock-up agreement with the Underwriters prohibiting transfers during the remainder of the lock-up period in a form satisfactory to the Representatives.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Reporting Requirements</font>.&#160; The Company, during the period when a Prospectus relating to the Securities is (or, but for the
      exception afforded by Rule 172, would be) required to be delivered under the 1933 Act, will file all documents required to be filed with the Commission pursuant to the 1934 Act within the time periods required by the 1934 Act and 1934 Act
      Regulations.&#160; Additionally, the Company shall report the use of proceeds from the issuance of the Securities as may be required under Rule 463 under the 1933 Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Issuer Free Writing Prospectuses</font>.&#160; The Company agrees that, unless it obtains the prior written consent of the
      Representatives, it will not make any offer relating to the Securities that would constitute an Issuer Free Writing Prospectus or that would otherwise constitute a &#8220;free writing prospectus,&#8221; or a portion thereof, required to be filed by the Company
      with the Commission or retained by the Company under Rule 433; provided that the Representatives will be deemed to have consented to the Issuer Free Writing Prospectuses listed on <u>Schedule&#160;B-2</u> hereto and any &#8220;road show that is a written
      communication&#8221; within the meaning of Rule 433(d)(8)(i) that has been reviewed by the Representatives.&#160; The Company represents that it has treated or agrees that it will treat each such free writing prospectus consented to, or deemed consented to, by
      the Representatives as an &#8220;issuer free writing prospectus,&#8221; as defined in Rule 433, and that it has complied and will comply with the applicable requirements of Rule 433 with respect thereto, including timely filing with the Commission where
      required, legending and record keeping.&#160; If at any time following issuance of an Issuer Free Writing Prospectus there occurred or occurs an event or development as a result of which such Issuer Free Writing Prospectus conflicted or would conflict
      with the information contained in the Registration Statement, any preliminary prospectus or the Prospectus or included or would include an untrue statement of a material fact or omitted or would omit to state a material fact necessary in order to
      make the statements therein, in the light of the circumstances existing at that subsequent time, not misleading, the Company will promptly notify the Representatives and will promptly amend or supplement, at its own expense, such Issuer Free Writing
      Prospectus to eliminate or correct such conflict, untrue statement or omission.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">21</font></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(l)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Testing-the-Waters Materials</font>.&#160; If at any time following the distribution of any Written Testing-the-Waters Communication there
      occurred or occurs an event or development as a result of which such Written Testing-the-Waters Communication included or would include an untrue statement of a material fact or omitted or would omit to state a material fact necessary in order to
      make the statements therein, in the light of the circumstances existing at that subsequent time, not misleading, the Company will promptly notify the Representatives and will promptly amend or supplement, at its own expense, such Written
      Testing-the-Waters Communication to eliminate or correct such untrue statement or omission.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 4.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Payment of Expenses</u>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Expenses</font>.&#160; The Company will pay or cause to be paid all expenses incident to the performance of its obligations under this
      Agreement, including (i) the preparation, printing and filing of the Registration Statement (including financial statements and exhibits) as originally filed and each amendment thereto, (ii)&#160;the preparation, printing and delivery to the Underwriters
      of copies of each preliminary prospectus, each Issuer Free Writing Prospectus and the Prospectus and any amendments or supplements thereto and any costs associated with electronic delivery of any of the foregoing by the Underwriters to investors,
      (iii) the preparation, issuance and delivery of the certificates or security entitlements for the Securities to the Underwriters, including any stock or other transfer taxes and any stamp or other duties payable upon the sale, issuance or delivery of
      the Securities to the Underwriters, (iv)&#160;the fees and disbursements of the Company&#8217;s counsel, accountants and other advisors, (v)&#160;the qualification of the Securities under securities laws in accordance with the provisions of Section&#160;3(e) hereof,
      including filing fees and the reasonable fees and disbursements of counsel for the Underwriters in connection therewith and in connection with the preparation of a &#8220;Blue Sky Survey&#8221; and any supplement thereto, not to exceed $5,000, (vi) the fees and
      expenses of any transfer agent or registrar for the Securities, (vii) the costs and expenses of the Company relating to investor presentations on any &#8220;road show&#8221; undertaken in connection with the marketing of the Securities, including without
      limitation, expenses associated with the production of road show slides and graphics, fees and expenses of any consultants engaged in connection with the road show presentations, travel and lodging expenses of the representatives and officers of the
      Company and any such consultants (provided that the travel and lodging of the Underwriters shall be paid by the Underwriters), (viii) the reasonable fees and disbursements of counsel to the Underwriters incurred in connection with determining the
      offering&#8217;s compliance with the rules and regulations of FINRA, including filing fees incident to any review, if required, by FINRA of the terms of the sale of the Securities not to exceed $25,000 and (ix) the fees and expenses incurred in connection
      with the listing of the Securities on the Nasdaq Global Market and Tel Aviv Stock Exchange.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Termination of Agreement</font>.&#160; If this Agreement is terminated by the Representatives in accordance with the provisions of
      Section&#160;5, Section&#160;9(a)(i), and Section 9(a)(iii), the Company shall reimburse the Underwriters for all of their reasonably documented out&#8209;of&#8209;pocket expenses, including the reasonable fees and disbursements of counsel for the Underwriters.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">22</font></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 5.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Conditions of Underwriters&#8217; Obligations</u>.&#160; The obligations of the several Underwriters hereunder are subject to the accuracy of the representations and
      warranties of the Company contained herein or in certificates of any officer of the Company or its Subsidiary delivered pursuant to the provisions hereof, to the performance by the Company of its covenants and other obligations hereunder, and to the
      following further conditions:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Effectiveness of Registration Statement</font>.&#160; The Registration Statement, including any Rule 462(b) Registration Statement, has
      become effective and, at the Closing Time, no stop order suspending the effectiveness of the Registration Statement or any post-effective amendment thereto has been issued under the 1933 Act, no order preventing or suspending the use of any
      preliminary prospectus or the Prospectus has been issued and no proceedings for any of those purposes have been instituted or are pending or, to the Company&#8217;s knowledge, contemplated; and the Company has complied with each request (if any) from the
      Commission for additional information to the reasonable satisfaction of counsel to the Underwriters.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Opinion of Counsel for Company</font>.&#160; At the Closing Time, the Representatives shall have received the opinion and the negative
      assurance letter, each dated the Closing Time, of Cooley LLP, U.S. counsel for the Company, and the opinion of Shibolet &amp; Co., Israeli counsel for the Company, together with the opinion of Morgan, Lewis &amp; Bockius LLP, special counsel for the
      Company with respect to intellectual property matters, each in form and substance satisfactory to counsel for the Underwriters.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Opinion of Counsel for Underwriters</font>.&#160; At the Closing Time, the Representatives shall have received the opinion, and negative
      assurance letter, each dated the Closing Time, of Covington &amp; Burling LLP, U.S. counsel for the Underwriters, and the opinion of Gornitzky &amp; Co., Israeli counsel for the Underwriters, together with signed or reproduced copies of such letters
      for each of the other Underwriters in form and substance satisfactory to the Representatives.&#160; In giving such opinion such U.S. counsel may rely, as to all matters governed by the laws of jurisdictions other than the law of the State of New York, the
      General Corporation Law of the State of Delaware and the federal securities laws of the United States, upon the opinions of counsel satisfactory to the Representatives.&#160; Such counsel may also state that, insofar as such opinion involves factual
      matters, they have relied, to the extent they deem proper, upon certificates of officers and other representatives of the Company and its Subsidiary and certificates of public officials.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Officers&#8217; Certificate</font>.&#160; At the Closing Time, there shall not have been, since the date hereof or since the respective dates as
      of which information is given in the Registration Statement, the General Disclosure Package or the Prospectus, any material adverse change in the condition, financial or otherwise, or in the earnings, business affairs or business prospects of the
      Company and its Subsidiary considered as one enterprise, whether or not arising in the ordinary course of business, and the Representatives shall have received a certificate of the principal executive officer of the Company and of the principal
      financial officer of the Company, dated the Closing Time, to the effect that (i) there has been no such material adverse change, (ii)&#160;the representations and warranties of the Company in this Agreement are true and correct with the same force and
      effect as though expressly made at and as of the Closing Time, (iii)&#160;the Company has complied with all agreements and satisfied all conditions on its part to be performed or satisfied at or prior to the Closing Time, and (iv)&#160;no stop order suspending
      the effectiveness of the Registration Statement under the 1933 Act has been issued, no order preventing or suspending the use of any preliminary prospectus or the Prospectus has been issued and no proceedings for any of those purposes have been
      instituted or are pending or, to their knowledge, contemplated.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Accountant&#8217;s Comfort Letter</font>.&#160; At the time of the execution of this Agreement, the Representatives shall have received from
      Kost Forer Gabbay &amp; Kasierer, a member of Ernst &amp; Young Global, a letter, dated such date, in form and substance satisfactory to the Representatives, together with signed or reproduced copies of such letter for each of the other Underwriters
      containing statements and information of the type ordinarily included in accountants&#8217; &#8220;comfort letters&#8221; to underwriters with respect to the financial statements and certain financial information contained in the Registration Statement, the General
      Disclosure Package and the Prospectus.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">23</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Bring-down Comfort Letter</font>.&#160; At the Closing Time, the Representatives shall have received from Kost Forer Gabbay &amp;
      Kasierer, a member of Ernst &amp; Young Global, a letter, dated as of the Closing Time, to the effect that they reaffirm the statements made in the letter furnished pursuant to subsection (e) of this Section, except that the specified date referred
      to shall be a date not more than three business days prior to the Closing Time.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Approval of Listing</font>.&#160; At the Closing Time, the Securities shall have been approved for listing on the Nasdaq Global Market,
      subject only to official notice of issuance.&#160; At the Closing Time, the Securities shall have been approved in principle for listing on the Tel Aviv Stock Exchange by the Tel Aviv Stock Exchange subject only to official notice of issuance, and the
      Underwriters shall have received, on or prior to the Closing Time, a copy of such principle approval of the Tel Aviv Stock Exchange for the listing for trade of the Securities on the Tel Aviv Stock Exchange.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">No Objection</font>.&#160; If applicable, FINRA has confirmed that it has not raised any objection with respect to the fairness and
      reasonableness of the underwriting terms and arrangements relating to the offering of the Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Lock-up Agreements</font>.&#160; At the date of this Agreement, the Representatives shall have received an agreement substantially in the
      form of <u>Exhibit&#160;A</u> hereto signed by all of the Company&#8217;s directors and officers named in the Company&#8217;s most recent Annual Report on Form 20-F.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Conditions to Purchase of Option Securities</font>.&#160; In the event that the Underwriters exercise their option provided in
      Section&#160;2(b) hereof to purchase all or any portion of the Option Securities, the representations and warranties of the Company contained herein and the statements in any certificates furnished by the Company and its Subsidiary hereunder shall be true
      and correct as of each Date of Delivery and, at the relevant Date of Delivery, the Representatives shall have received:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Officers&#8217; Certificate</u>.&#160; A certificate, dated such Date of Delivery, of the principal executive officer of the Company and of the principal
      financial officer of the Company confirming that the certificate delivered at the Closing Time pursuant to Section&#160;5(d) hereof remains true and correct as of such Date of Delivery.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Opinion of Counsel for Company</u>.&#160; If requested by the Representatives, the opinion, and negative assurance letter, of Cooley LLP, U.S.
      counsel for the Company, and the opinion of Shibolet &amp; Co., Israeli counsel for the Company, together with the opinion of Morgan, Lewis &amp; Bockius LLP, special counsel for the Company with respect to intellectual property matters, each in form
      and substance satisfactory to counsel for the Underwriters, dated such Date of Delivery, relating to the Option Securities to be purchased on such Date of Delivery and otherwise to the same effect as the opinions and negative assurance letter
      required by Section&#160;5(b) hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Opinion of Counsel for Underwriters</u>.&#160; If requested by the Representatives, the opinion, and negative assurance letter, of Covington &amp;
      Burling LLP, U.S. counsel for the Underwriters, and the opinion of Gornitzky &amp; Co., Israeli counsel for the Underwriters, dated such Date of Delivery, relating to the Option Securities to be purchased on such Date of Delivery and otherwise to the
      same effect as the opinion and negative assurance letter required by Section&#160;5(c) hereof.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">24</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Bring-down Comfort Letter</u>.&#160; If requested by the Representatives, a letter from Kost Forer Gabbay &amp; Kasierer, a member of Ernst &amp;
      Young Global, in form and substance satisfactory to the Representatives and dated such Date of Delivery, substantially in the same form and substance as the letter furnished to the Representatives pursuant to subsection (f) of this Section, except
      that the &#8220;specified date&#8221; in the letter furnished pursuant to this paragraph shall be a date not more than three business days prior to such Date of Delivery.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Additional Documents</font>.&#160; At the Closing Time and at each Date of Delivery (if any), counsel for the Underwriters shall have been
      furnished with such other documents and opinions as they may reasonably require for the purpose of enabling them to pass upon the issuance and sale of the Securities as herein contemplated, or in order to evidence the accuracy of any of the
      representations or warranties, or the fulfillment of any of the conditions, herein contained; and all proceedings taken by the Company in connection with the issuance and sale of the Securities as herein contemplated shall be reasonably satisfactory
      in form and substance to the Representatives and counsel for the Underwriters.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(l)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Termination of Agreement</font>.&#160; If any condition specified in this Section shall not have been fulfilled when and as required to be
      fulfilled, this Agreement, or, in the case of any condition to the purchase of Option Securities on a Date of Delivery which is after the Closing Time, the obligations of the several Underwriters to purchase the relevant Option Securities, may be
      terminated by the Representatives by notice to the Company at any time at or prior to Closing Time or such Date of Delivery, as the case may be, and such termination shall be without liability of any party to any other party except as provided in
      Section 4 and except that Sections 1, 4, 6, 7, 8, 15, 16 and 17 shall survive any such termination and remain in full force and effect.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 6.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Indemnification</u>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Indemnification of Underwriters</font>.&#160; The Company agrees to indemnify and hold harmless each Underwriter, its affiliates (as such
      term is defined in Rule 501(b) under the 1933 Act (each, an &#8220;<u>Affiliate</u>&#8221;)), its selling agents and each person, if any, who controls any Underwriter within the meaning of Section&#160;15 of the 1933 Act or Section 20 of the 1934 Act (such
      Affiliates, selling agents and controlling persons, each an &#8220;<u>Underwriter Indemnitee</u>&#8221;) as follows:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;against any and all loss, liability, claim, damage and expense whatsoever, as incurred, arising out of any untrue statement or alleged untrue
      statement of a material fact contained in the Registration Statement (or any amendment thereto), including any information deemed to be a part thereof pursuant to Rule 430B, or the omission or alleged omission therefrom of a material fact required to
      be stated therein or necessary to make the statements therein not misleading or arising out of any untrue statement or alleged untrue statement of a material fact included (A) in any preliminary prospectus, any Issuer Free Writing Prospectus, any
      Written Testing-the-Waters Communication, the General Disclosure Package or the Prospectus (or any amendment or supplement thereto), or (B) in any materials or information provided to investors by, or with the approval of, the Company in connection
      with the marketing of the offering of the Securities (&#8220;<u>Marketing Materials</u>&#8221;), including any roadshow or investor presentations made to investors by the Company (whether in person or electronically), or the omission or alleged omission in any
      preliminary prospectus, any Issuer Free Writing Prospectus, any Written Testing-the-Waters Communication, the General Disclosure Package, the Prospectus (or any amendment or supplement thereto) or in any Marketing Materials of a material fact
      necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;against any and all loss, liability, claim, damage and expense whatsoever, as incurred, to the extent of the aggregate amount paid in settlement of
      any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or of any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission; provided
      that (subject to Section 6(d) below) any such settlement is effected with the written consent of the Company;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">25</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;against any and all expense whatsoever, as incurred (including the reasonable fees and disbursements of counsel chosen by the Representatives),
      reasonably incurred in investigating, preparing or defending against any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever based upon any such untrue statement or
      omission, or any such alleged untrue statement or omission, to the extent that any such expense is not paid under (i) or (ii) above;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">provided, however, that this indemnity agreement shall not apply to any loss, liability, claim, damage or expense to the extent arising out of any untrue statement or omission or alleged untrue
      statement or omission made in the Registration Statement (or any amendment thereto), including any information deemed to be a part thereof pursuant to Rule 430B, the General Disclosure Package or the Prospectus (or any amendment or supplement
      thereto) in reliance upon and in conformity with the Underwriter Information.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Indemnification of Company, Directors and Officers</font>.&#160; Each Underwriter severally agrees to indemnify and hold harmless the
      Company, its directors, each of its officers who signed the Registration Statement, and each person, if any, who controls the Company within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act, against any and all loss, liability,
      claim, damage and expense described in the indemnity contained in subsection (a) of this Section, as incurred, but only with respect to untrue statements or omissions, or alleged untrue statements or omissions, made in the Registration Statement (or
      any amendment thereto), including any information deemed to be a part thereof pursuant to Rule 430B, the General Disclosure Package or the Prospectus (or any amendment or supplement thereto) in reliance upon and in conformity with the Underwriter
      Information.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Actions against Parties; Notification</font>.&#160; Each indemnified party shall give notice as promptly as reasonably practicable to each
      indemnifying party of any action commenced against it in respect of which indemnity may be sought hereunder, but failure to so notify an indemnifying party shall not relieve such indemnifying party from any liability hereunder to the extent it is not
      materially prejudiced as a result thereof and in any event shall not relieve it from any liability which it may have otherwise than on account of this indemnity agreement.&#160; In the case of parties indemnified pursuant to Section 6(a) above, counsel to
      the indemnified parties shall be selected by the Representatives, and, in the case of parties indemnified pursuant to Section 6(b) above, counsel to the indemnified parties shall be selected by the Company.&#160; An indemnifying party may participate at
      its own expense in the defense of any such action; provided, however, that counsel to the indemnifying party shall not (except with the consent of the indemnified party) also be counsel to the indemnified party.&#160; In no event shall the indemnifying
      parties be liable for the reasonable fees and expenses of more than one counsel (in addition to any local counsel) separate from their own counsel for all indemnified parties in connection with any one action or separate but similar or related
      actions in the same jurisdiction arising out of the same general allegations or circumstances.&#160; No indemnifying party shall, without the prior written consent of the indemnified parties, settle or compromise or consent to the entry of any judgment
      with respect to any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever in respect of which indemnification or contribution could be sought under this Section 6 or
      Section 7 hereof (whether or not the indemnified parties are actual or potential parties thereto), unless such settlement, compromise or consent (i) includes an unconditional release of each indemnified party from all liability arising out of such
      litigation, investigation, proceeding or claim and (ii) does not include a statement as to or an admission of fault, culpability or a failure to act by or on behalf of any indemnified party.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">26</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Settlement without Consent if Failure to Reimburse</font>.&#160; If at any time an indemnified party shall have requested an indemnifying
      party to reimburse the indemnified party for fees and expenses of counsel, such indemnifying party agrees that it shall be liable for any settlement of the nature contemplated by Section 6(a)(ii) effected without its written consent if (i) such
      settlement is entered into more than 45 days after receipt by such indemnifying party of the aforesaid request, (ii) such indemnifying party shall have received notice of the terms of such settlement at least 30 days prior to such settlement being
      entered into and (iii) such indemnifying party shall not have reimbursed such indemnified party in accordance with such request prior to the date of such settlement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 7.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Contribution</u>.&#160; If the indemnification provided for in Section&#160;6 hereof is for any reason unavailable to or insufficient to hold harmless an indemnified
      party in respect of any losses, liabilities, claims, damages or expenses referred to therein, then each indemnifying party shall contribute to the aggregate amount of such losses, liabilities, claims, damages and expenses incurred by such indemnified
      party, as incurred, (i) in such proportion as is appropriate to reflect the relative benefits received by the Company, on the one hand, and the Underwriters, on the other hand, from the offering of the Securities pursuant to this Agreement or (ii) if
      the allocation provided by clause (i) is not permitted by applicable law, in such proportion as is appropriate to reflect not only the relative benefits referred to in clause (i) above but also the relative fault of the Company, on the one hand, and
      of the Underwriters, on the other hand, in connection with the statements or omissions which resulted in such losses, liabilities, claims, damages or expenses, as well as any other relevant equitable considerations.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The relative benefits received by the Company, on the one hand, and the Underwriters, on the other hand, in connection with the offering of the Securities pursuant to this
      Agreement shall be deemed to be in the same respective proportions as the total net proceeds from the offering of the Securities pursuant to this Agreement (before deducting expenses) received by the Company, on the one hand, and the total
      underwriting discount received by the Underwriters, on the other hand, in each case as set forth on the cover of the Prospectus, bear to the aggregate initial public offering price of the Securities as set forth on the cover of the Prospectus.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The relative fault of the Company, on the one hand, and the Underwriters, on the other hand, shall be determined by reference to, among other things, whether any such untrue or
      alleged untrue statement of a material fact or omission or alleged omission to state a material fact relates to information supplied by the Company or by the Underwriters and the parties&#8217; relative intent, knowledge, access to information and
      opportunity to correct or prevent such statement or omission.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company and the Underwriters agree that it would not be just and equitable if contribution pursuant to this Section 7 were determined by pro rata allocation (even if the
      Underwriters were treated as one entity for such purpose) or by any other method of allocation which does not take account of the equitable considerations referred to above in this Section 7.&#160; The aggregate amount of losses, liabilities, claims,
      damages and expenses incurred by an indemnified party and referred to above in this Section 7 shall be deemed to include any legal or other expenses reasonably incurred by such indemnified party in investigating, preparing or defending against any
      litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever based upon any such untrue or alleged untrue statement or omission or alleged omission.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Notwithstanding the provisions of this Section 7, no Underwriter shall be required to contribute any amount in excess of the underwriting discounts and commissions received by such
      Underwriter in connection with the Securities underwritten by it and distributed to the public.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">27</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the 1933 Act) shall be entitled to contribution from any person who was not guilty of such
      fraudulent misrepresentation.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">For purposes of this Section 7, each person, if any, who controls an Underwriter within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act and each
      Underwriter&#8217;s Affiliates and selling agents shall have the same rights to contribution as such Underwriter, and each director of the Company, each officer of the Company who signed the Registration Statement, and each person, if any, who controls the
      Company within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act shall have the same rights to contribution as the Company.&#160; The Underwriters&#8217; respective obligations to contribute pursuant to this Section 7 are several in
      proportion to the number of Initial Securities set forth opposite their respective names in <u>Schedule&#160;A</u> hereto and not joint.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 8.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Representations, Warranties and Agreements to Survive</u>.&#160; All representations, warranties and agreements contained in this Agreement or in certificates of
      officers of the Company or of its Subsidiary submitted pursuant hereto, shall remain operative and in full force and effect regardless of (i) any investigation made by or on behalf of any Underwriter or its Affiliates or selling agents, any person
      controlling any Underwriter, its officers or directors or any person controlling the Company and (ii) delivery of and payment for the Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 9.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Termination of Agreement</u>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Termination</font>.&#160; The Representatives may terminate this Agreement, by notice to the Company, at any time at or prior to the
      Closing Time (i) if there has been, in the judgment of the Representatives, since the time of execution of this Agreement or since the respective dates as of which information is given in the Registration Statement, the General Disclosure Package or
      the Prospectus, any material adverse change in the condition, financial or otherwise, or in the earnings, business affairs or business prospects of the Company and its Subsidiary considered as one enterprise, whether or not arising in the ordinary
      course of business, or (ii)&#160;if there has occurred any material adverse change in the financial markets in the United States or the international financial markets, any outbreak of hostilities or escalation thereof or other calamity or crisis or any
      change or development involving a prospective change in U.S. or international political, financial or economic conditions, in each case the effect of which is such as to make it, in the judgment of the Representatives, impracticable or inadvisable to
      proceed with the completion of the offering or to enforce contracts for the sale of the Securities, or (iii)&#160;if trading in any securities of the Company has been suspended or materially limited by the Commission or the Nasdaq Global Market or the Tel
      Aviv Stock Exchange, or (iv) if trading generally on the Nasdaq Global Market or the Tel Aviv Stock Exchange has been suspended or materially limited, or minimum or maximum prices for trading have been fixed, or maximum ranges for prices have been
      required, by any of said exchanges or by order of the Commission, FINRA or any other governmental authority, or (v)&#160;a material disruption has occurred in commercial banking or securities settlement or clearance services in the United States or with
      respect to Clearstream or Euroclear systems in Europe, or (vi) if a banking moratorium has been declared by any of U.S. federal, New York or Israeli authorities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;">Liabilities</font>.&#160; If this Agreement is terminated pursuant to this Section, such termination shall be without liability of any
      party to any other party except as provided in Section 4 hereof, and provided further that Sections 1, 4, 6, 7, 8, 15, 16 and 17 shall survive such termination and remain in full force and effect.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">28</font></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 10.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Default by One or More of the Underwriters</u>.&#160; If one or more of the Underwriters shall fail at the Closing Time or a Date of Delivery to purchase the
      Securities which it or they are obligated to purchase under this Agreement (the &#8220;<u>Defaulted Securities</u>&#8221;), the Representatives shall have the right, within 24&#160;hours thereafter, to make arrangements for one or more of the non&#8209;defaulting
      Underwriters, or any other underwriters, to purchase all, but not less than all, of the Defaulted Securities in such amounts as may be agreed upon and upon the terms herein set forth; if, however, the Representatives shall not have completed such
      arrangements within such 24&#8209;hour period, then:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;if the number of Defaulted Securities does not exceed 10% of the number of Securities to be purchased on such date, each of the non&#8209;defaulting
      Underwriters shall be obligated, severally and not jointly, to purchase the full amount thereof in the proportions that their respective underwriting obligations hereunder bear to the underwriting obligations of all non&#8209;defaulting Underwriters, or</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;if the number of Defaulted Securities exceeds 10% of the number of Securities to be purchased on such date, this Agreement or, with respect to any
      Date of Delivery which occurs after the Closing Time, the obligation of the Underwriters to purchase, and the Company to sell, the Option Securities to be purchased and sold on such Date of Delivery shall terminate without liability on the part of
      any non&#8209;defaulting Underwriter.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">No action taken pursuant to this Section shall relieve any defaulting Underwriter from liability in respect of its default.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In the event of any such default which does not result in a termination of this Agreement or, in the case of a Date of Delivery which is after the Closing Time, which does not
      result in a termination of the obligation of the Underwriters to purchase and the Company to sell the relevant Option Securities, as the case may be, either the (i) Representatives or (ii) the Company shall have the right to postpone Closing Time or
      the relevant Date of Delivery, as the case may be, for a period not exceeding seven days in order to effect any required changes in the Registration Statement, the General Disclosure Package or the Prospectus or in any other documents or
      arrangements.&#160; As used herein, the term &#8220;Underwriter&#8221; includes any person substituted for an Underwriter under this Section 10.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 11.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Notices</u>.&#160; All notices and other communications hereunder shall be in writing and shall be deemed to have been duly given if mailed or transmitted by any
      standard form of telecommunication.&#160; Notices to the Underwriters shall be directed to SVB Leerink at 1301 Avenue of the Americas, 12<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor, New York, New York, 10019, attention of Stuart R. Nayman and to Stifel, Nicolaus &amp; Company,
      Incorporated, 787 Seventh Avenue, 11th Floor, New York, New York 10019, attention of Equity Capital Markets, with a copy to Covington &amp; Burling at The New York Times Building, 620 Eighth Avenue, New York, New York, 10018, attention of Donald J.
      Murray and Brian K. Rosenzweig.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 12.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Advisory or Fiduciary Relationship</u>.&#160; The Company acknowledges and agrees that (a) the purchase and sale of the Securities pursuant to this Agreement,
      including the determination of the initial public offering price of the Securities and any related discounts and commissions, is an arm&#8217;s-length commercial transaction between the Company, on the one hand, and the several Underwriters, on the other
      hand, (b) in connection with the offering of the Securities and the process leading thereto, each Underwriter is and has been acting solely as a principal and is not the agent or fiduciary of the Company, its Subsidiary or their respective
      stockholders, creditors, employees or any other party, (c) no Underwriter has assumed or will assume an advisory or fiduciary responsibility in favor of the Company with respect to the offering of the Securities or the process leading thereto
      (irrespective of whether such Underwriter has advised or is currently advising the Company or its Subsidiary on other matters) and no Underwriter has any obligation to the Company with respect to the offering of the Securities except the obligations
      expressly set forth in this Agreement, (d) the Underwriters and their respective affiliates may be engaged in a broad range of transactions that involve interests that differ from those of the Company and (e) the Underwriters have not provided any
      legal, accounting, regulatory or tax advice with respect to the offering of the Securities and the Company has consulted its own respective legal, accounting, regulatory and tax advisors to the extent it deemed appropriate.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">29</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 13.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Recognition of the U.S. Special Resolution Regimes</u>.&#160; In the event that any Underwriter that is a Covered Entity becomes subject to a proceeding under a
      U.S. Special Resolution Regime, the transfer from such Underwriter of this Agreement, and any interest and obligation in or under this Agreement, will be effective to the same extent as the transfer would be effective under the U.S. Special
      Resolution Regime if this Agreement, and any such interest and obligation, were governed by the laws of the United States or a state of the United States.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In the event that any Underwriter that is a Covered Entity or a BHC Act Affiliate of such Underwriter becomes subject to a proceeding under a U.S. Special Resolution Regime,
      Default Rights under this Agreement that may be exercised against such Underwriter are permitted to be exercised to no greater extent than such Default Rights could be exercised under the U.S. Special Resolution Regime if this Agreement were governed
      by the laws of the United States or a state of the United States.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">For purposes of this Agreement, (A) &#8220;BHC Act Affiliate&#8221; has the meaning assigned to the term &#8220;affiliate&#8221; in, and shall be interpreted in accordance with, 12 U.S.C. &#167; 1841(k); (B)
      &#8220;Covered Entity&#8221; means any of the following: (i) a &#8220;covered entity&#8221; as that term is defined in, and interpreted in accordance with, 12 C.F.R. &#167; 252.82(b); (ii) a &#8220;covered bank&#8221; as that term is defined in, and interpreted in accordance with, 12 C.F.R.
      &#167; 47.3(b); or (iii) a &#8220;covered FSI&#8221; as that term is defined in, and interpreted in accordance with, 12 C.F.R. &#167; 382.2(b); (C) &#8220;Default Right&#8221; has the meaning assigned to that term in, and shall be interpreted in accordance with, 12 C.F.R. &#167;&#167; 252.81,
      47.2 or 382.1, as applicable; and (D) &#8220;U.S. Special Resolution Regime&#8221; means each of (i) the Federal Deposit Insurance Act and the regulations promulgated thereunder and (ii) Title II of the Dodd-Frank Wall Street Reform and Consumer Protection Act
      and the regulations promulgated thereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 14.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Parties</u>.&#160; This Agreement shall each inure to the benefit of and be binding upon the Underwriters and the Company and their respective successors.&#160;
      Nothing expressed or mentioned in this Agreement is intended or shall be construed to give any person, firm or corporation, other than the Underwriters and the Company and their respective successors and their respective controlling persons,
      officers, directors, Affiliates and selling agents referred to in Sections&#160;6 and 7 and their heirs and legal representatives, any legal or equitable right, remedy or claim under or in respect of this Agreement or any provision herein contained.&#160; This
      Agreement and all conditions and provisions hereof are intended to be for the sole and exclusive benefit of the Underwriters and the Company and their respective successors, and said controlling persons, officers, directors, Affiliates and selling
      agents and their heirs and legal representatives, and for the benefit of no other person, firm or corporation.&#160; No purchaser of Securities from any Underwriter shall be deemed to be a successor by reason merely of such purchase.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 15.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Waiver of Trial by Jury</u>.&#160; The Company (on its behalf and, to the extent permitted by applicable law, on behalf of its shareholders and affiliates) and
      each of the Underwriters hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to this Agreement or the transactions contemplated hereby.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 16.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>GOVERNING LAW</u>.&#160; THIS AGREEMENT AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN
      ACCORDANCE WITH THE LAWS OF, THE STATE OF NEW YORK WITHOUT REGARD TO ITS CHOICE OF LAW PROVISIONS.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 17.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Consent to Jurisdiction; Waiver of Immunity</u>.&#160; Any legal suit, action or proceeding arising out of or based upon this Agreement or the transactions
      contemplated hereby shall&#160;be instituted in (i) the federal courts of the United States of America located in the City and County of New York, Borough of Manhattan or&#160;(ii) the courts of the State of New York located in the City and County of New York,
      Borough of Manhattan (collectively, the &#8220;<u>Specified Courts</u>&#8221;), and each party irrevocably submits to the exclusive jurisdiction (except for proceedings instituted in regard to the enforcement of a judgment of any such court, as to which such
      jurisdiction is non-exclusive) of such courts in any such suit, action or proceeding.&#160; The Company hereby appoints Compugen USA, Inc., with offices at 250 E. Grand Ave, Suite 65, South San Francisco CA, 90480, as its agent for service of process in
      any suit, action or proceeding and agrees that service of process in any such suit, action or proceeding may be made upon it at the office of such agent.&#160; The Company waives, to the fullest extent permitted by law, any other requirements of or
      objections to personal jurisdiction with respect thereto.&#160; The Company represents and warrants that such agent has agreed to act as the Company&#8217;s agent for service of process, and the Company agrees to take any and all action, including the filing of
      any and all documents and instruments, that may be necessary to continue such appointment in full force and effect.&#160; In the event that Compugen USA, Inc. is unable to serve as such agent, the Company hereby agrees to maintain the uninterrupted
      designation of an authorized agent upon whom process may be served in any such suit, action or proceeding and agrees to notify the Representatives of the name and address of any such future authorized agent.&#160; Service of any process, summons, notice
      or document by mail to such party&#8217;s address set forth above shall be effective service of process for any suit, action or other proceeding brought in any such court.&#160; The parties irrevocably and unconditionally waive any objection to the laying of
      venue of any suit, action or other proceeding in the Specified Courts and irrevocably and unconditionally waive and agree not to plead or claim in any such court that any such suit, action or other proceeding brought in any such court has been
      brought in an inconvenient forum.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">30</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 18.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Currency Provisions</u>.&#160; The obligations of the Company pursuant to this Agreement in respect of any sum due to any Underwriter or Underwriter Indemnitee
      shall, notwithstanding any judgment in a currency other than United States dollars, not be discharged until the first business day, following receipt by any Underwriter or Underwriter Indemnitee of any sum adjudged to be so due in such other
      currency, on which such Underwriter or Underwriter Indemnitee may in accordance with normal banking procedures purchase United States dollars with such other currency.&#160; If the United States dollars so purchased are less than the sum originally due to
      such Underwriter or Underwriter Indemnitee in United States dollars hereunder, the Company agrees as a separate obligation and notwithstanding any such judgment, to indemnify such Underwriter or Underwriter Indemnitee against such loss.&#160; If the
      United States dollars so purchased are greater than the sum originally due to such Underwriter or Underwriter Indemnitee hereunder, such Underwriter agrees to pay, or to cause such Underwriter Indemnitee to pay, to the Company, an amount equal to the
      excess of the dollars so purchased over the sum originally due to such Underwriter or Underwriter Indemnitee hereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All payments made or deemed to be made by the Company under this Agreement, if any, will be made without withholding or deduction for or on account of any present or future taxes,
      duties, assessments or governmental charges of whatever nature (other than taxes on net income) imposed or levied by or on behalf of the State of Israel or any political subdivision or any taxing authority thereof or therein unless the Company is or
      becomes required by law to withhold or deduct such taxes, duties, assessments or other governmental charges.&#160; In such event, the Company will pay such additional amounts as will result, after such withholding or deduction, in the receipt by each
      Underwriter and each Underwriter Indemnitee, as the case may be, of the amounts that would otherwise have been receivable in respect thereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 19.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>TIME</u>.&#160; TIME SHALL BE OF THE ESSENCE OF THIS AGREEMENT.&#160; EXCEPT AS OTHERWISE SET FORTH HEREIN, SPECIFIED TIMES OF DAY REFER TO NEW YORK CITY TIME.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">31</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 20.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Partial Unenforceability</u>.&#160; The invalidity or unenforceability of any Section, paragraph or provision of this Agreement shall not affect the validity or
      enforceability of any other Section, paragraph or provision hereof.&#160; If any Section, paragraph or provision of this Agreement is for any reason determined to be invalid or unenforceable, there shall be deemed to be made such minor changes (and only
      such minor changes) as are necessary to make it valid and enforceable.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 21.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Counterparts</u>.&#160; This Agreement may be executed in any number of counterparts (which may include counterparts&#160; delivered by any standard form of
      telecommunication), each of which shall be deemed to be an original, but all such counterparts shall together constitute one and the same agreement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 22.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Effect of Headings</u>.&#160; The Section headings herein are for convenience only and shall not affect the construction hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="background-color: #FFFFFF; line-height: 1.25;">
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECTION 23.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="background-color: #FFFFFF;"><u>Entire Agreement</u></font><font style="background-color: #FFFFFF;">.&#160; This Agreement supersedes all prior
          agreements and understandings (whether written or oral) between the Company and the Underwriters, or any of them, with respect to the subject matter hereof.</font></div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: center; line-height: 1.25;">[SIGNATURE PAGES FOLLOW]</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">32</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If the foregoing is in accordance with your understanding of our agreement, please sign and return to the Company a counterpart hereof, whereupon this instrument, along with all
      counterparts, will become a binding agreement among the Underwriters and the Company in accordance with its terms.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <table cellspacing="0" cellpadding="0" border="0" id="z7776ffd9ba7b498b90cc4dc311038efd" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Very truly yours,</div>
                <div style="line-height: 1.25;"><br style="line-height: 1.25;">
                </div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">COMPUGEN LTD.</div>
                <div style="line-height: 1.25;"><br style="line-height: 1.25;">
                </div>
                <div style="text-align: left; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif;">By:</font> <font style="font-family: 'Times New Roman',Times,serif;"><u>/s/ Anat Cohen-Dayag</u>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font></div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;&#160;&#160;&#160;&#160;&#160; Name: Anat Cohen-Dayag</div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;&#160;&#160;&#160;&#160;&#160; Title: President and Chief Executive Officer</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>&#160;<br>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>
                <div style="text-align: left; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif;">By:</font> <font style="font-family: 'Times New Roman',Times,serif;"><u>/s/ Ari Krashin</u>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font></div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;&#160;&#160;&#160;&#160;&#160; Name: Ari Krashin</div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;&#160;&#160;&#160;&#160;&#160; Title: Chief Financial and Operating Officer</div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">CONFIRMED AND ACCEPTED</div>
    <div style="text-indent: 18pt; line-height: 1.25;">As of the date first above written:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">SVB LEERINK LLC</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">By: <u>/s/ Jon Civitarese</u></div>
    <div style="text-indent: 18pt; line-height: 1.25;">Name: Jon Civitarese</div>
    <div style="text-indent: 18pt; line-height: 1.25;">Title: Managing Director</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">STIFEL, NICOLAUS &amp; COMPANY, INCORPORATED</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">By: <u>/s/ Seth Rubin</u></div>
    <div style="text-indent: 18pt; line-height: 1.25;">Name: Seth Rubin</div>
    <div style="text-indent: 18pt; line-height: 1.25;">Title: Managing Director</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">For themselves and as Representatives of the other Underwriters named in <u>Schedule&#160;A</u> hereto.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps;">[Signature Page to Underwriting Agreement]</div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div id="DSPFPageHeader">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="text-align: center; line-height: 1.25;">SCHEDULE A</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">The initial public offering price per share for the Securities shall be $9.00.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">The purchase price per share for the Securities to be paid by the several Underwriters shall be $8.46, being an amount equal to the initial public offering price set forth above less $0.54 per share, subject to
      adjustment in accordance with Section 2(b) for dividends or distributions declared by the Company and payable on the Initial Securities but not payable on the Option Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z8c17945a6ad1457082c97e9d68119c23" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

        <tr>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;">
            <div style="line-height: 1.25;">Name of Underwriter</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td valign="bottom" colspan="2" style="vertical-align: bottom; border-bottom: #000000 solid 2px;">
            <div style="text-align: center; line-height: 1.25;">Number of<br>
              Initial Securities</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="2" style="vertical-align: top;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 88%; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25;">SVB Leerink LLC&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25;">3,541,667</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 88%; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">Stifel, Nicolaus &amp; Company, Incorporated&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">2,708,334</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 88%; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25;">SunTrust Robinson Humphrey, Inc.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25;">1,166,667</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 88%; padding-bottom: 2px; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">Oppenheimer &amp; Co. Inc.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">916,666</div>
            </div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 88%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">
            <div style="margin-left: 36pt; line-height: 1.25;">Total&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">8,333,334</div>
            </div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    <div style="text-align: center; line-height: 1.25;">SCHEDULE B-1</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><u>Pricing Terms</u></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">1.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company is selling 8,333,334 Ordinary Shares.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">2.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company has granted an option to the Underwriters, severally and not jointly, to purchase up to an additional 1,250,000 Ordinary Shares.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">3.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The initial public offering price per share for the Securities shall be $9.00.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div id="DSPFPageHeader">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="text-align: center; line-height: 1.25;">SCHEDULE B-2</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><u>Free Writing Prospectuses</u></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">None</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageHeader">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="text-align: center; line-height: 1.25;">SCHEDULE B-3</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><u>List of Written Testing-the-Waters Communications</u></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">None</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: right; line-height: 1.25;">Exhibit A</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;">FORM OF LOCK-UP AGREEMENT</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">March [&#9679;], 2020</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">SVB Leerink LLC</div>
    <div style="line-height: 1.25;">Stifel, Nicolaus &amp; Company, Incorporated</div>
    <div style="line-height: 1.25;">as Representatives of the several Underwriters</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">c/o SVB Leerink LLC</div>
    <div style="line-height: 1.25;">One Federal Street, 37th Floor</div>
    <div style="line-height: 1.25;">Boston, MA 02110</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">c/o Stifel, Nicolaus &amp; Company, Incorporated</div>
    <div style="line-height: 1.25;">787 Seventh Avenue, 11th Floor</div>
    <div style="line-height: 1.25;">New York, New York 10019</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Re:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Proposed Public Offering by Compugen Ltd.</u></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">Ladies and Gentlemen:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The undersigned, an officer and/or director of Compugen Ltd., a corporation organized under the laws of the State of Israel (the &#8220;<u>Company</u>&#8221;), understands that SVB Leerink LLC
      (&#8220;<u>SVB Leerink</u>&#8221;) and Stifel, Nicolaus &amp; Company, Incorporated (&#8220;<u>Stifel</u>&#8221;) propose to enter into an Underwriting Agreement (the &#8220;<u>Underwriting Agreement</u>&#8221;) with the Company providing for the public offering (the &#8220;<u>Public
        Offering</u>&#8221;) of ordinary shares, nominal (par) value NIS 0.01 per share, of the Company (the &#8220;<u>Ordinary Shares</u>&#8221;).&#160; In recognition of the benefit that such an offering will confer upon the undersigned as an officer and/or a director of the
      Company, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the undersigned agrees with each underwriter to be named in the Underwriting Agreement (collectively, the &#8220;<u>Underwriters</u>&#8221;)
      that, during the period beginning on the date hereof and ending on the date that is 90 days from the date of the Underwriting Agreement (the &#8220;<u>Lock-Up Period</u>&#8221;), the undersigned will not, without the prior written consent of SVB Leerink and
      Stifel, on behalf of the Underwriters, directly or indirectly, (i) offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant for the sale of, or
      otherwise dispose of or transfer any Ordinary Shares or any securities convertible into or exchangeable or exercisable for Ordinary Shares, whether now owned or hereafter acquired by the undersigned or with respect to which the undersigned has or
      hereafter acquires the power of disposition (collectively, the &#8220;<u>Lock-Up Securities</u>&#8221;), or exercise any right with respect to the registration of any of the Lock-Up Securities, or file or cause to be filed any registration statement in
      connection therewith, under the Securities Act of 1933, as amended, or (ii) enter into any swap or any other agreement or any transaction that transfers, in whole or in part, directly or indirectly, the economic consequence of ownership of the
      Lock-Up Securities, whether any such swap or transaction is to be settled by delivery of Ordinary Shares or other securities, in cash or otherwise.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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    <!--PROfilePageNumberReset%Num%2%-%-%-->
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Notwithstanding the foregoing, and subject to the conditions below, the undersigned may transfer Lock-Up Securities without the prior written consent of SVB Leerink and Stifel,
      provided, in each case, that (1)&#160;only in the case of clauses (i), (ii), (iii) and (iv) below, SVB Leerink and Stifel receive a signed lock-up agreement for the balance of the Lock-Up Period from each donee, trustee, distributee, or transferee, as the
      case may be, (2) any such transfer shall not involve a disposition for value, (3) such transfers are not required to be reported with the Securities and Exchange Commission (the &#8220;<u>SEC</u>&#8221;) on Form 4 in accordance with Section 16 of the Securities
      Exchange Act of 1934, as amended (the &#8220;<u>Exchange Act</u>&#8221;), and (4) the undersigned does not otherwise voluntarily effect any public filing or report regarding such transfers (other than a filing on a Form 5 made after the expiration of the Lock-Up
      Period):</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
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            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(i)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>as a <font style="font-style: italic;">bona fide</font> gift or gifts;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6ed44683b8274b3887f590614728ac0d">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(ii)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>to any member of the immediate family of the undersigned or to a trust for the direct or indirect benefit of the undersigned or the immediate family of the undersigned (for purposes of this lock-up agreement, &#8220;immediate family&#8221; shall
                  mean any relationship by blood, marriage or adoption, not more remote than first cousin);</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6812adbc62b44c51b83a6937388b469f">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(iii)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>as a distribution or other transfer by a partnership to its partners or former partners or by a limited liability company to its members or retired members or by a corporation to its shareholders or former shareholders or to any
                  wholly-owned subsidiary of such corporation;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd6f98a7f69174f22af3fa8bb771fc365">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(iv)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>to the undersigned&#8217;s affiliates or to any investment fund or other entity controlled or managed by the undersigned;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9f135706ed0f40a3b005d9084b122401">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(v)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>pursuant to a qualified domestic relations order or in connection with a divorce settlement or other court order;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zff7be2f83caf4e1da0abc264f53136c5">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(vi)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>to the Company pursuant to the repurchase provisions of existing employment agreements and equity grant documents; provided that any filing under Section 16(a) of the Exchange Act in connection with such transfer shall indicate, to the
                  extent permitted by such Section and the related rules and regulations, the reason for such disposition and that such transfer of Shares was solely to the Company;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf40e0d3e08424bb497ddc1b3534caedc">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(vii)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>acquired in open-market transactions after the completion of the Public Offering;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zbe3b3703126848aab85f9474ce4f998f">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(viii)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>by will or intestate succession upon the death of the undersigned; or</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4b503df3533042d2b26c2ad46260a5cf">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; align: right;">(ix)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>to the Company in satisfaction of any tax withholding obligation.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Furthermore, no provision in this letter shall be deemed to restrict or prohibit (1) the transfer of the undersigned&#8217;s Lock-Up Securities to the Company in connection with the
      termination of the undersigned&#8217;s services to the Company, provided that any filing under Section 16 of the Exchange Act made in connection with such transfer shall clearly indicate in the footnotes thereto that the filing relates to the circumstances
      described in this clause (1); (2) the exercise or exchange by the undersigned of any option or warrant to acquire any Ordinary Shares or options to purchase Ordinary Shares, in each case for cash or on a &#8220;cashless&#8221; or &#8220;net exercise&#8221; basis, pursuant
      to any share option, share bonus or other share plan or arrangement; provided, however, that the underlying Ordinary Shares shall continue to be subject to the restrictions on transfer set forth in this letter and that any filing under Section 16 of
      the Exchange Act made in connection with such exercise or exchange shall clearly indicate in the footnotes thereto that (a) the filing relates to the circumstances described in this clause (2) and (b) no shares were sold by the reporting person; and
      (3) the transfer of Lock-Up Securities upon the completion of a bona fide third-party tender offer, merger, consolidation or other similar transaction made to all holders of the Company&#8217;s securities involving a &#8220;change of control&#8221; (as defined below)
      of the Company; provided, however, that in the event that such tender offer, merger, consolidation or other such transaction is not completed, such securities held by the undersigned shall remain subject to the restrictions on transfer set forth in
      this letter.&#160; For purposes of this clause, &#8220;change of control&#8221; means the consummation of any bona fide third party tender offer, merger, consolidation or other similar transaction the result of which is that, in one transaction or a series of related
      transactions, any &#8220;person&#8221; (as defined in Section 13(d)(3) of the Exchange Act), or group of persons, other than the Company, becomes the beneficial owner (as defined in Rules 13d-3 and 13d-5 of the Exchange Act) of more than 50% of total voting
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Notwithstanding anything herein to the contrary, nothing herein shall prevent the undersigned from establishing a 10b5-1 trading plan that complies with Rule 10b5-1 under the
      Exchange Act (&#8220;<u>10b5-1 Trading Plan</u>&#8221;) so long as there are no sales of Lock-Up Securities under any such 10b5-1 Trading Plan during the Lock-Up Period; and provided that, the establishment of a 10b5-1 Trading Plan shall only be permitted if (i)
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      establishment or amendment of such plan.</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The undersigned also agrees and consents to the entry of stop transfer instructions with the Company&#8217;s transfer agent and registrar against the transfer of the Lock-Up Securities
      except in compliance with the foregoing restrictions.&#160; This lock-up agreement shall automatically terminate, and the undersigned shall be released from the undersigned&#8217;s obligations hereunder, upon the earliest to occur, if any, of (i) prior to the
      execution of the Underwriting Agreement, (A) the Company advises SVB Leerink and Stifel in writing that it has determined not to proceed with the Public Offering or (B) SVB Leerink and Stifel, on behalf of the Underwriters, advise the Company in
      writing that they have determined not to proceed with the Public Offering; (ii) the Underwriting Agreement is executed but is terminated prior to the closing of the Public Offering (other than the provisions thereof which survive termination), or
      (iii) March 31, 2020, in the event that the Underwriting Agreement has not been executed by such date.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This agreement shall be governed by, and construed in accordance with, the laws of the State of New York.</div>
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                  <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">Very truly yours,</font></div>
                  <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">________________________________________</font></div>
                  <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">Name of Security Holder </font><font style="background-color: rgb(255, 255, 255); font-style: italic;">(Print exact name</font><font style="background-color: rgb(255, 255, 255);">)</font></div>
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                  </div>
                  <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">By:________________________________________</font></div>
                  <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">&#160;&#160;&#160;&#160;&#160;&#160;Signature</font></div>
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                  </div>
                  <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">If not signing in an individual capacity:</font></div>
                  <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">________________________________________</font></div>
                  <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="background-color: rgb(255, 255, 255);">Name of Authorized Signatory </font><font style="background-color: rgb(255, 255, 255); font-style: italic;">(Print</font><font style="background-color: rgb(255, 255, 255);">)</font></div>
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<DESCRIPTION>EXHIBIT 5.1
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        <div style="text-align: right; line-height: 1.25;"><u><font style="font-weight: bold;">Exhibit 5.1</font></u><br>
        </div>
        <div style="line-height: 1.25;"><br>
        </div>
        <div style="text-align: center; line-height: 1.25;"><img src="image00002.jpg"></div>
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      <div style="text-align: center; text-indent: 36pt; line-height: 1.25;">Tel-Aviv, March 13, 2020</div>
      <div style="line-height: 1.25;"> <br>
      </div>
      <div style="line-height: 1.25;">Compugen Ltd.</div>
      <div style="line-height: 1.25;">26 Harokmim Street, Holon<br>
        Azrieli Center, Building D<br>
        Israel</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Ladies and Gentlemen:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">We have acted as Israeli counsel to Compugen Ltd., a company limited by shares organized under the laws of the state of Israel (the "<font style="font-weight: bold;">Company</font>"), in connection
        with the Prospectus Supplement dated March 11, 2020 filed pursuant to Rule 424(b)(5) under the Securities Act of 1933 (the "<font style="font-weight: bold;">Act</font>"), (the "<font style="font-weight: bold;">Pro-Supp</font>"), and the
        Registration Statement on Form F-3 (File No.&#160;333-233001) (the "<font style="font-weight: bold;">Registration Statement</font>") filed by the Company under the Act with the Securities and Exchange Commission (the "<font style="font-weight: bold;">SEC</font>")
        on August 5, 2019 and declared effective on August 12, 2019 , relating to the offering of 8,333,334 ordinary shares of the Company, par value NIS 0.01 per share (the "<font style="font-weight: bold;">Shares</font>"), as well as a 30 day option to
        acquire an additional 1,250,000 ordinary shares of the Company to cover over allotments in connection with the above offering (the "<font style="font-weight: bold;">Additional Shares</font>").</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">This opinion is being furnished in accordance with the requirements of Item 601(b)(5)(i) of Regulation S-K.</div>
      <div style="text-align: justify; line-height: 1.25;">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;">In our capacity as your Israeli counsel in connection with your preparation and filing of the Pro-Supp, we have examined and relied without investigation as to matters of fact upon the Pro-Supp and
        the exhibits thereto, and upon such certificates, upon statements and results of inquiries of public officials and officers and representatives of the Company and originals or copies, certified or otherwise identified to our satisfaction, of such
        other documents, corporate records, certificates and instruments as we have deemed necessary or appropriate to enable us to render the opinions expressed herein. We have assumed the genuineness of all signatures on all documents examined by us, the
        legal competence and capacity of all natural persons, the correctness and completeness of certificates of public officials and the representations set forth therein, the authenticity of all documents submitted to us as originals and the conformity
        to authentic original documents of all documents submitted to us as copies. As to any facts material to the opinions expressed herein which were not independently established or verified, we have relied upon oral or written statements and
        representations of officers and other representatives of the Company.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">Based upon the foregoing, in reliance thereon and subject to the assumptions, comments, qualifications, limitations and exceptions stated herein and the effectiveness of the Pro-Supp under the Act,
        we are of the opinion that the Shares and Additional Shares have been duly authorized for issuance, and when issued, upon payment of the consideration therefor as contemplated in the Underwriting Agreement dated as of&#160; March 11, 2020, among SVB
        Leerink LLC, Stifel, Nicolaus &amp; Company, Incorporated, and the Company (the "Underwriting Agreement") will be validly issued, fully paid and non-assessable.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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      <div style="text-align: justify; line-height: 1.25;"> <br>
      </div>
      <div style="text-align: justify; line-height: 1.25;">In addition to the assumptions, comments, qualifications, limitations and exceptions set forth above, the opinions set forth herein are further limited by, subject to and based upon the following
        assumptions, comments, qualifications, limitations and exceptions:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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        <div>
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                <td style="width: 18pt; vertical-align: top; align: right;">1.</td>
                <td style="width: auto; vertical-align: top; text-align: justify;">
                  <div>We are members of the Israel Bar and we are opining herein as to the effect of the subject transaction only on the internal laws of the State of Israel, and we express no opinion with respect to the applicability thereto, or the
                    effect thereon, of the laws of any other jurisdiction. In rendering our opinions, we have not considered, and hereby disclaim any opinion as to, the application or impact of any laws, cases, decisions, rules or regulations of any other
                    jurisdiction, court or administrative agency. This opinion is expressly limited to the matters set forth above, and we render no opinion, whether by implication or otherwise, as to any other matters.</div>
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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">
        <div>
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                <td style="width: 18pt; vertical-align: top; align: right;">2.</td>
                <td style="width: auto; vertical-align: top; text-align: justify;">
                  <div>Our opinions herein are subject to and may be limited by (i) applicable bankruptcy, insolvency, reorganization, receivership, moratorium and other similar laws affecting or relating to the rights and remedies of creditors generally
                    including, without limitation, laws relative to fraudulent conveyances, preference and equitable subordination; (ii) general principles of equity (regardless of whether considered in a proceeding in equity or at law); and (iii)
                    principles of good faith and fair dealing.</div>
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                <td style="width: 18pt; vertical-align: top; align: right;">3.</td>
                <td style="width: auto; vertical-align: top; text-align: justify;">
                  <div>Our opinions are further subject to the effect of generally applicable rules of law arising from statutes, judicial and administrative decisions, and the rules and regulations of governmental authorities that: (i) limit or affect the
                    enforcement of provisions of a contract that purport to require waiver of the obligations of good faith, fair dealing, diligence and reasonableness; (ii) limit the availability of a remedy under certain circumstances where another
                    remedy has been elected; (iii) limit the enforceability of provisions releasing, exculpating or exempting a party from, or requiring indemnification of a party for, liability for its own action or inaction, to the extent the action or
                    inaction involves negligence, recklessness, willful misconduct or unlawful conduct; (iv) may, where less than all of the contract may be unenforceable, limit the enforceability of the balance of the contract to circumstances in which
                    the unenforceable portion is not an essential part of the agreed exchange; and (v) govern and afford judicial discretion regarding the determination of damages and entitlement to attorneys' fees.</div>
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      <div style="text-align: justify; line-height: 1.25;">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;">
        <div>
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                <td style="width: 18pt; vertical-align: top; align: right;">4.</td>
                <td style="width: auto; vertical-align: top; text-align: justify;">
                  <div>You have informed us that you may issue the Additional Shares within a period of 30 days as of the date hereof, following the exercise of an option to purchase the Additional Shares by the underwriters under the Pro-Supp, and this
                    opinion is limited to the laws, including the rules and regulations, as in effect on the date hereof. We understand that prior to issuing any of the Additional Shares you will afford us an opportunity to review the operative documents
                    pursuant to which such Additional Shares are to be issued and we will file such supplement or amendment to this opinion (if any) as we may reasonably consider necessary or appropriate by reason of the terms of such Additional Shares.</div>
                </td>
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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">We consent to the filing of this opinion letter as an exhibit to a Report on Form 6-K and to the use of our name under the caption "Legal Matters" in the Pro-Supp. In giving this consent, we do not
        thereby admit that we are within the category of persons whose consent is required under Section 7 of the Act or the rules and regulations promulgated thereunder.</div>
      <div style="text-align: justify; line-height: 1.25;">&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">2</font></div>
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      <div style="text-align: justify; line-height: 1.25;"> <img src="image00003.jpg"></div>
      <div style="text-align: justify; line-height: 1.25;"> <br>
      </div>
      <div style="text-align: justify; line-height: 1.25;">This opinion letter is rendered as of the date first written above and we disclaim any obligation to advise you of facts, circumstances, events or developments, including, without limitation, in
        the law, which hereafter may be brought to our attention and which may alter, affect or modify the opinion expressed herein.&#160;&#160;Our opinion is expressly limited to the matters set forth above and we render no opinion, whether by implication or
        otherwise, as to any other matters relating to the Company, the Shares or the Additional Shares, except as set forth above.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 50%; vertical-align: top;">
              <div style="line-height: 1.25;">Very truly yours,</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
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              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">/s/ Shibolet &amp; Co., Law Firm</div>
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