<SEC-DOCUMENT>0001178913-20-001028.txt : 20200406
<SEC-HEADER>0001178913-20-001028.hdr.sgml : 20200406
<ACCEPTANCE-DATETIME>20200406070514
ACCESSION NUMBER:		0001178913-20-001028
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20200406
FILED AS OF DATE:		20200406
DATE AS OF CHANGE:		20200406

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		20775706

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk2024235.htm
<DESCRIPTION>6-K
<TEXT>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C. 20549</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">Form 6-K</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25;">For the month of April 2020</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25;">Commission File Number 000-30902</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold;">COMPUGEN LTD.</div>
      <div style="text-align: center; line-height: 1.25;">(Translation of registrant&#8217;s name into English)</div>
      <table cellspacing="0" cellpadding="0" id="z2fa4a58ecfe1485aa6293bbb04dd3e45" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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              <div style="line-height: 1.25;">&#160;</div>
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            <td style="width: 100%; vertical-align: bottom;">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">26&#160;Harokmim Street</div>
            </td>
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            <td style="width: 100%; vertical-align: bottom;">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Holon 5885849, Israel</div>
            </td>
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            <td style="width: 100%; vertical-align: bottom;">
              <div style="text-align: center; line-height: 1.25;">(Address of Principal Executive Offices)&#160;</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:</div>
      <div style="line-height: 1.25;"> <br>
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Form 20-F&#160; &#9746; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Form 40-F&#160; &#9744;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): &#160; &#160; &#160; &#160; &#9744;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): &#160; &#160; &#160; &#160; &#9744;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="line-height: 1.25;">On April 6, 2020, Compugen Ltd. (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;)
          issued a press release, a copy of which is furnished as Exhibit 99.1 to this Form 6-K and incorporated by reference herein.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="line-height: 1.25;">The information contained in the first and second paragraphs and the section titled &#8220;Forward-Looking Statement&#8221; in the press release is
          hereby incorporated by reference into the Company&#8217;s Registration Statement on Form F-3, File No.&#160;<font style="background-color: #FFFFFF;">333-233001.</font></div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Exhibits</div>
      <div style="line-height: 1.25; font-weight: bold;">Exhibit</div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">
          <div>
            <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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                  <td style="width: 72pt; vertical-align: top; align: right;"><font style="font-weight: bold;"><u>Number</u></font><br>
                  </td>
                  <td style="width: auto; vertical-align: top;">
                    <div>
                      <div style="line-height: 1.25;"><font style="font-weight: bold;"><u>Description of Exhibit</u></font></div>
                    </div>
                  </td>
                </tr>

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          </div>
        </div>
        <font style="font-weight: bold;"><u> </u></font></div>
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          <table cellspacing="0" cellpadding="0" id="z0e8658bddf75404aa563cfa185bf656b" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 72pt; vertical-align: top; align: right;"><a href="exhibit_99-1.htm">99.1</a></td>
                <td style="width: auto; vertical-align: top;">
                  <div><a href="exhibit_99-1.htm">Press Release dated April 6, 2020.</a></div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signatures</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its
        behalf by the undersigned thereunto duly authorized.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="z5eb869dafa4b4d15aa0aa18416a2a5bb" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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              <div style="line-height: 1.25;">&#160;</div>
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            <td style="vertical-align: bottom;" colspan="3">
              <div style="line-height: 1.25; font-weight: bold;">COMPUGEN LTD.</div>
            </td>
          </tr>
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            <td style="vertical-align: middle;" colspan="4">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
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            <td style="width: 46%; vertical-align: bottom;">
              <div style="line-height: 1.25;">Date: April 6, 2020</div>
            </td>
            <td style="width: 4%; vertical-align: bottom;">
              <div style="line-height: 1.25;">By:&#160;</div>
            </td>
            <td style="width: 25%; vertical-align: bottom; border-bottom: 2px solid black;">
              <div style="line-height: 1.25;">/s/ Eran Ben Dor&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="text-align: center; line-height: 1.25;">&#160;</div>
            </td>
          </tr>
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            <td style="width: 46%; vertical-align: bottom;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 4%; vertical-align: bottom;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="line-height: 1.25;">Eran Ben Dor</div>
              <div style="line-height: 1.25;">General Counsel</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="text-align: center; line-height: 1.25;">&#160;</div>
            </td>
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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>exhibit_99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
<html>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
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    <div style="text-align: right;"><u><font style="font-weight: bold;">Exhibit 99.1</font></u><br>
    </div>
    <div> <br>
    </div>
    <div>
      <div id="DSPFPageHeader">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <div style="line-height: 1.25;">&#160;<img width="128" height="53" src="image0.jpg"></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">FOR IMMEDIATE RELEASE</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-weight: bold;">Compugen Announces First Patient Dosed
        in COM902 Phase 1 Trial for</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-weight: bold;"> Patients with Advanced Malignancies</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-style: italic; font-weight: bold;">Initial data expected in 2021</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-style: italic; font-weight: bold;">COM902 and COM701 will allow the Company to clinically evaluate the dual blockade of PVRIG </div>
      <div style="text-align: center; line-height: 1.25; font-style: italic; font-weight: bold;">and TIGIT inhibitory pathways in the DNAM axis</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">HOLON, ISRAEL, April 6, 2020 &#8211; <u>Compugen Ltd.</u>
        (Nasdaq: CGEN), a clinical-stage cancer immunotherapy company and a leader in predictive target discovery, today announced that the first patient has been dosed in its Phase 1 clinical trial of COM902, an immuno-oncology therapeutic antibody
        targeting TIGIT, in patients with advanced malignancies.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">This Phase 1 open-label clinical trial is designed to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and
        preliminary antitumor activity of escalating doses of COM902 monotherapy in patients with advanced malignancies who have exhausted all available standard therapies. The study will be conducted in multiple leading oncology clinical centers in the
        United States.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Manish Sharma, M.D., Associate Director of Clinical Research at START Midwest (Grand Rapids, MI) and a Principal Investigator in the
        Phase 1 COM902 study, said, &#8220;Being part of Compugen&#8217;s ongoing COM701 Phase 1 study, we are excited to expand our relationship with the Company and enroll patients in this clinical trial evaluating the inhibition of TIGIT, a part of the DNAM axis,
        with COM902. There remains a high unmet medical need to evaluate novel investigational agents in patients unresponsive to PD-1 or PDL-1 inhibitors. The two studies enable us to evaluate COM701 and COM902 in these patient populations.&#8221;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Anat Cohen-Dayag, Ph.D., President and CEO of Compugen, added &#8220;Advancing COM902 through Phase 1 studies is an important step towards
        testing the clinical effect of the dual blockade of PVRIG and TIGIT, two parallel inhibitory pathways in the DNAM axis. Our preclinical work suggests that the simultaneous blockade of TIGIT and PVRIG may be essential for inducing robust antitumor
        immune responses in patient populations where these two pathways are operative. This is further reinforced by our initial clinical data demonstrating preliminary antitumor activity by COM701 targeting PVRIG and pharma&#8217;s increasing focus on the
        blockade of TIGIT, which we and others discovered in 2009. As the only company, to our knowledge, currently with clinical programs targeting both TIGIT and PVRIG, we are uniquely positioned to synergistically target both immune checkpoints.&#8221;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Dr. Cohen-Dayag continued, &#8220;Our various clinical studies targeting PVRIG and TIGIT, including the Phase 1/2 trial designed to evaluate
        the triple blockade of PVRIG, TIGIT and PD-1 expected to initiate in the second half of 2020, build our science-driven clinical pipeline designed to address the significant unmet need of patients who are non-responsive and refractory to currently
        approved cancer immunotherapies. We look forward to the multiple anticipated data readouts from our clinical studies, including updated data from our ongoing COM701 monotherapy and combination therapy dose escalation studies later this year, and
        from our COM701 Phase 1 monotherapy expansion cohorts and COM902 Phase 1 studies in 2021.&#8221;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Additional information on the COM902 Phase 1 study will be available shortly at <u>www.clinicaltrials.gov</u>.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">About COM902</div>
      <div style="line-height: 1.25;">COM902 is a high affinity, fully human antibody that blocks the interaction of TIGIT with PVR, its ligand, and consequently enhances T
        cell function. It is currently being evaluated in a Phase 1 clinical trial in patients with advanced malignancies who have exhausted all available standard therapies. Compugen has demonstrated in preclinical studies that simultaneous inhibition of
        TIGIT and PVRIG, the two coinhibitory arms of the DNAM axis, can increase antitumor immune responses, which may be further enhanced with the addition of PD-1 blockade. These data suggest that treatment with COM701 and COM902, targeting PVRIG and
        TIGIT, respectively, alone or in combination with a PD-1 inhibitor, has the potential to expand immuno-oncology treatment to patient populations who are non-responsive or refractory to existing immunotherapies.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">The discovery of TIGIT, using the Company&#8217;s computational discovery platform, was published by Compugen in October 2009 in the
        Proceedings of the National Academy of Sciences (PNAS).</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">About Compugen</div>
      <div style="line-height: 1.25;">Compugen is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable, predictive computational
        discovery platforms to identify novel drug targets and develop therapeutics in the field of cancer immunotherapy. The Company&#8217;s lead product candidate, COM701, a
        first-in-class anti-PVRIG antibody, for the treatment of solid tumors, is undergoing a Phase 1 clinical study. In addition, COM902, Compugen&#8217;s antibody targeting
        TIGIT, is in a Phase 1 clinical study. The Company&#8217;s therapeutic pipeline also includes early stage immuno-oncology programs focused largely on myeloid targets.
        Compugen&#8217;s business model is to selectively enter into collaborations for its novel targets and related drug product candidates at various stages of research and
        development. The Company is headquartered in Israel, with offices in South San Francisco, CA. Compugen&#8217;s shares are listed on the Nasdaq and the Tel Aviv Stock Exchange under the ticker symbol CGEN. For additional information, please visit
        Compugen&#8217;s corporate website at <u>www.cgen.com</u>.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">Forward-Looking Statement</div>
      <div style="line-height: 1.25;">This press release contains &#8220;forward-looking
        statements&#8221; within the meaning of the Securities Act of 1933 and the Securities Exchange Act of 1934, as amended, and the safe-harbor provisions of the Private
        Securities Litigation Reform Act of 1995. Such forward-looking statements are based on the current beliefs, expectations and assumptions of Compugen. Forward-looking statements can be identified by the use of terminology such as &#8220;will,&#8221;&#160;&#8220;may,&#8221;&#160;&#8220;expects,&#8221;&#160;&#8220;anticipates,&#8221;&#160;&#8220;believes,&#8221;&#160;&#8220;potential,&#8221;&#160;&#8220;plan,&#8221;&#160;&#8220;goal,&#8221;&#160;&#8220;estimate,&#8221;&#160;&#8220;likely,&#8221;&#160;&#8220;should,&#8221;&#160;&#8220;confident,&#8221; and &#8220;intends,&#8221; and similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements include, but are not limited to, statements regarding fact that the COM902 phase 1<font style="font-weight: bold;">&#160;</font>study will be conducted in multiple leading oncology clinical centers in the United States, our expectation that the Phase 1/2 trial designed to evaluate the triple blockade of PVRIG, TIGIT and
        PD-1 pathways will be initiated in the second half of 2020 and our statement that the multiple anticipated data readouts from our clinical studies, including more updated data from our ongoing COM701 monotherapy and combination with nivolumab dose
        escalation studies will are anticipated later this year and from our COM701 Phase 1 monotherapy expansion cohorts and COM902 Phase 1 study in 2021. These forward-looking statements involve known and unknown risks and uncertainties that may cause
        the actual results, performance or achievements of Compugen to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Among these risks: Compugen&#8217;s operations and the
        operations of the multiple leading oncology clinical centers in the United States in which the COM902 phase 1 study will be conducted could be affected by the outbreak and spread of the Coronavirus; clinical development involves a lengthy and
        expensive process, with an uncertain outcome and Compugen may encounter substantial delays or even an inability to begin clinical trials for any specific product, or may not be able to conduct or complete its trials on the timelines it expects;
        Compugen relies, and expects to continue to rely, on third parties to conduct its clinical trials and if these third parties do not successfully carry out their contractual duties, comply with regulatory requirements or meet expected deadlines
        (including as a result of the effect of the Coronavirus), Compugen may experience significant delays in the conduct of its clinical trials and obtain data readouts; Compugen&#8217;s ability to present data derived from collaborations with its partners is dependent in some cases on the agreement of our partners to present such data, and in any event is dependent on its acceptance to present data in relevant
        conferences; Compugen&#8217;s approach to the discovery of therapeutic products is based on its proprietary computational target discovery infrastructure, which is
        unproven clinically; Compugen does not know whether it will be able to discover and develop additional potential product candidates or products of commercial value; Compugen&#8217;s business model is substantially dependent on entering into collaboration agreements with third parties; and Compugen may not be successful in generating adequate revenues or commercializing aspects of its business model. These
        risks and other risks are more fully described in the &#8220;Risk Factors&#8221; section of
        Compugen&#8217;s most recent Annual Report on Form 20-F filed with the Securities and Exchange Commission (SEC) as well as other documents that may be subsequently filed
        by Compugen from time to time with the SEC. In addition, any forward-looking statements represent Compugen&#8217;s views only as of the date of this release and should
        not be relied upon as representing its views as of any subsequent date. Compugen does not assume any obligation to update any forward-looking statements unless required by law.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25;"><font style="font-weight: bold;">Company contact:</font><br>
        Elana Holzman<br>
        Director, Investor Relations and Corporate Communications<br>
        Compugen Ltd.<br>
        Email: <u>elanah@cgen.com</u><br>
        Tel: +972 (3) 765-812</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25;"><font style="font-weight: bold;">Investor Relations contact:</font><br>
        Bob Yedid<br>
        LifeSci Advisors, LLC<br>
        Email: <u>bob@lifesciadvisors.com</u><br>
        Tel: +1 (646) 597-6989</div>
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      <div style="line-height: 1.25;"><font style="font-weight: bold;">Media contact:</font><br>
        Josephine Belluardo, Ph.D.<br>
        LifeSci Communications<br>
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        Tel: +1 (646) 751-4361</div>
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