<SEC-DOCUMENT>0001178913-20-003428.txt : 20201223
<SEC-HEADER>0001178913-20-003428.hdr.sgml : 20201223
<ACCEPTANCE-DATETIME>20201223070212
ACCESSION NUMBER:		0001178913-20-003428
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20201223
FILED AS OF DATE:		20201223
DATE AS OF CHANGE:		20201223

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		201409770

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk2025282.htm
<DESCRIPTION>6-K
<TEXT>
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    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Form 6-K</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">For the month of December 2020</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">Commission File Number 000-30902</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">COMPUGEN LTD.</div>
    <div style="text-align: center; line-height: 1.25;">(Translation of registrant&#8217;s name into English)</div>
    <table cellspacing="0" cellpadding="0" id="z51bbbcffd7bd4f988c40cde8287f6f27" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>
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          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">26&#160;Harokmim Street</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Holon 5885849, Israel</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">(Address of Principal Executive Offices)&#160;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:</div>
    <div style="line-height: 1.25;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Form 20-F&#160;&#9746; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Form 40-F &#9744;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): &#9744;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): &#9744;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">On December 23, 2020, Compugen Ltd. (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;)
        issued a press release, a copy of which is filed as Exhibit 99.1 to this Report on Form 6-K and is incorporated by reference herein.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">The information contained in the first and fourth paragraphs and the section titled &#8220;Forward-Looking Statement&#8221; in the press release is
        hereby incorporated by reference into the Company&#8217;s Registration Statement on Form F-3, File No.&#160;333-240183.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Exhibits</div>
    &#160;<br>
    <table cellspacing="0" cellpadding="0" id="z0c61c25d546f4a87a241456d9d8bc145" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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          <td style="width: 72pt; vertical-align: top; align: right;">
            <div>
              <div style="line-height: 1.25; font-weight: bold;">Exhibit</div>
              <div style="line-height: 1.25;"><font style="font-weight: bold;"><u>Number</u></font></div>
            </div>
            <div> <br>
            </div>
            <div><a href="exhibit_99-1.htm">99.1</a></div>
          </td>
          <td style="width: auto; vertical-align: top;">
            <div> <font style="font-weight: bold;"><u>Description of Exhibit</u></font></div>
            <div> <br>
            </div>
            <div> <br>
            </div>
            <div><a href="exhibit_99-1.htm">Press Release dated December 23, 2020.</a></div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br>
      <br style="line-height: 1.25;">
    </div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signatures</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf
      by the undersigned thereunto duly authorized.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z6bdb28f6f4eb46a1878276da7bc4f128" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="vertical-align: bottom;" colspan="3">
            <div style="line-height: 1.25; font-weight: bold;">COMPUGEN LTD.</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: middle;" colspan="4">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
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          <td style="width: 50%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Date: December 23, 2020</div>
          </td>
          <td style="width: 3%; vertical-align: bottom;">
            <div style="line-height: 1.25;">By:&#160;</div>
          </td>
          <td style="width: 35%; vertical-align: bottom; border-bottom: 2px solid black;">
            <div style="line-height: 1.25;">/s/ Eran Ben Dor&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
          </td>
          <td style="width: 12%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">&#160;</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 35%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Eran Ben Dor</div>
            <div style="line-height: 1.25;">General Counsel</div>
          </td>
          <td style="width: 12%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">&#160;</div>
          </td>
        </tr>

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      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
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    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25">&#160;</div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>exhibit_99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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  <div>
    <p style="margin-bottom:0in;margin-bottom:.0001pt; mso-add-space:auto;line-height:120%;background:white" class="MsoNormalCxSpFirst"> </p>
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
    <div style="text-align: right;"><u><font style="font-weight: bold;">Exhibit 99.1</font></u><br>
    </div>
    <p style="margin-bottom:0in;margin-bottom:.0001pt; mso-add-space:auto;line-height:120%;background:white" class="MsoNormalCxSpFirst"><b><font style="line-height: 120%; font-family: 'Times New Roman',serif; color: rgb(34, 34, 34);">
          </font></b></p>
    <br>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><img width="125" height="53" src="image0.jpg">
        <div><br>
        </div>
      </div>
    </div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">FOR IMMEDIATE RELEASE</div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Compugen Announces First Development Milestone in License <br>
          Agreement with </font><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">AstraZeneca </font><font style="background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-style: normal; font-variant: normal; text-transform: none;">for the Development of Bispecific </font></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><font style="background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-style: normal; font-variant: normal; text-transform: none;">and Multi-Specific Antibody Products</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">HOLON, ISRAEL &#8211; December 23, 2020 &#8211; <u>Compugen Ltd.</u>
      (Nasdaq: CGEN), a clinical-stage cancer immunotherapy company and a leader in
      predictive target discovery, announced today progress from its ongoing license agreement with AstraZeneca (LSE/STO/Nasdaq: AZN), under which the program has achieved a preclinical milestone. Under the terms of the agreement, Compugen provided an exclusive license to AstraZeneca for the development of bispecific and multi-specific antibody products based on one of Compugen&#8217;s pipeline programs, with AstraZeneca responsible for all research, development and commercial activities. In connection with this first milestone, Compugen is entitled to receive a $2
      million payment from AstraZeneca.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">&#8220;AstraZeneca choosing Compugen as a partner for its bispecific and multi-specific development plans is testament to the power of our
      platform, and we are proud that this program has now advanced to demonstrate therapeutic potential,&#8221; said Anat Cohen-Dayag, Ph.D., President and CEO of Compugen. &#8220;This license agreement has enabled Compugen to monetize one of our programs outside our
      development focus and is part of our larger strategy to selectively collaborate with biopharmaceutical companies to leverage our diverse, computationally-discovered pipeline for the development of novel cancer immunotherapies. We are delighted that
      AstraZeneca has chosen to continue the development of this bispecific program, providing further validation of Compugen&#8217;s discovery and development capabilities.&#8221;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">About the Compugen-AstraZeneca License Agreement</div>
    <div style="line-height: 1.25;">In April 2018, Compugen and AstraZeneca<font style="font-weight: bold;">&#160;</font>entered
      into an agreement by which Compugen provided an exclusive license to AstraZeneca for the development of bispecific and multi-specific antibody products derived from one of Compugen&#8217;s pipeline programs. AstraZeneca has the right to create multiple
      products under this license and is solely responsible for all research, development and commercial activities. Compugen received a $10&#160;million upfront payment and is
      eligible to receive up to $200 million in development, regulatory and commercial milestones for the first product as well as tiered royalties on future product sales. If additional products are developed, additional milestones and royalties would be
      due to Compugen. Under the terms of the license agreement, Compugen retained all other rights to its entire pipeline of programs as monotherapies and in combination with other products.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">About Compugen</div>
    <div style="line-height: 1.25;">Compugen is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable, predictive computational
      discovery platforms to identify novel drug targets and develop therapeutics in the field of cancer immunotherapy. The Company&#8217;s lead product candidate, COM701, a first-in-class anti-PVRIG antibody, for the treatment of solid tumors, is undergoing a
      Phase 1 clinical study. In addition, COM902, Compugen&#8217;s antibody targeting TIGIT, is in a Phase 1 clinical study. The Company&#8217;s therapeutic pipeline also includes early stage immuno-oncology programs focused largely on myeloid targets. The Company is
      headquartered in Israel, with offices in South San Francisco, CA. Compugen&#8217;s shares are listed on the Nasdaq and the Tel Aviv Stock Exchange under the ticker symbol CGEN. For additional information, please visit Compugen&#8217;s corporate website at
      www.cgen.com.</div>
    <div style="line-height: 1.25;"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Forward-Looking Statement</div>
    <div style="line-height: 1.25;">This press release contains &#8220;forward-looking statements&#8221; within the meaning of the Securities Act of 1933, as amended, the Securities
      Exchange Act of 1934, as amended, and the safe-harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on the current beliefs, expectations and assumptions of Compugen. Forward-looking
      statements can be identified by the use of terminology such as &#8220;will,&#8221; &#8220;may,&#8221; &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;believes,&#8221; &#8220;potential,&#8221; &#8220;plan,&#8221; &#8220;goal,&#8221; &#8220;estimate,&#8221; &#8220;likely,&#8221; &#8220;should,&#8221; &#8220;confident,&#8221; and &#8220;intends,&#8221; and similar expressions that are intended to
      identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements, including statements related to the payment of the milestone payment and our strategy to selectively
      collaborate with biopharmaceutical companies, involve known and unknown risks and uncertainties that may cause the actual results, performance or achievements of Compugen to be materially different from any future results, performance or achievements
      expressed or implied by such forward-looking statements. Among these risks: Compugen&#8217;s operations could be affected by the outbreak and spread of COVID-19; clinical development involves a lengthy and expensive process, with an uncertain outcome and
      Compugen may encounter substantial delays or even an inability to begin clinical trials for any specific product, or may not be able to conduct or complete its trials on the timelines it expects; Compugen relies, and expects to continue to rely, on
      third parties to conduct its clinical trials and if these third parties do not successfully carry out their contractual duties, comply with regulatory requirements or meet expected deadlines (including as a result of the effect of the COVID-19),
      Compugen may experience significant delays in the conduct of its clinical trials; Compugen&#8217;s approach to the discovery of therapeutic products is based on its proprietary computational target discovery infrastructure, which is unproven clinically;
      There can be no assurance that Compugen will be able to discover and develop additional potential product candidates or products of commercial value; Compugen&#8217;s business model is substantially dependent on entering into collaboration agreements with
      third parties; and Compugen may not be successful in generating adequate revenues or commercializing aspects of its business model. These risks and other risks are more fully discussed in the &#8220;Risk Factors&#8221; section of Compugen&#8217;s most recent Annual
      Report on Form 20-F as filed with the Securities and Exchange Commission (SEC) as well as other documents that may be subsequently filed by Compugen from time to time with the SEC. In addition, any forward-looking statements represent Compugen&#8217;s
      views only as of the date of this release and should not be relied upon as representing its views as of any subsequent date. Compugen does not assume any obligation to update any forward-looking statements unless required by law.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Company contact:</div>
    <div style="line-height: 1.25;">Elana Holzman</div>
    <div style="line-height: 1.25;">Director, Investor Relations and Corporate Communications Compugen Ltd.</div>
    <div style="line-height: 1.25;">Email: elanah@cgen.com</div>
    <div style="line-height: 1.25;">Tel: +972 (3) 765-8124</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Investor Relations contact:</div>
    <div style="line-height: 1.25;">Bob Yedid</div>
    <div style="line-height: 1.25;">LifeSci Advisors, LLC</div>
    <div style="line-height: 1.25;">Email: bob@lifesciadvisors.com</div>
    <div style="line-height: 1.25;">Tel: +1 (646) 597-6989</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Media contact:</div>
    <div style="line-height: 1.25;">Josephine Belluardo, Ph.D.</div>
    <div style="line-height: 1.25;">LifeSci Communications</div>
    <div style="line-height: 1.25;">Email: jo@lifescicomms.com</div>
    <div style="line-height: 1.25;">Tel: +1 (646) 751-4361</div>
    <div style="line-height: 1.25;"> <br>
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